#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6NY15 uniprotkb:Q16665 intact:EBI-8549230|uniprotkb:Q68RJ4|intact:MINT-2634910|uniprotkb:Q8K3V2|ensembl:ENSMUSP00000048859 intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018 psi-mi:tsg10_mouse(display_long)|uniprotkb:Tsga10(gene name)|psi-mi:Tsga10(display_short) psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hägele et al. (2006) pubmed:16777103|imex:IM-10961|mint:MINT-5218745 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8549251|mint:MINT-2634921|imex:IM-10961-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_997111.1|refseq:NP_001277649.1|refseq:NP_001277650.1|ensembl:ENSMUSG00000060771(gene)|ensembl:ENSMUST00000041815(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043005"(neuron projection)|go:"GO:0097228"(sperm principal piece)|interpro:IPR033323|mint:Q6NY15|mint:MINT-2634923(identity) refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664|mint:MINT-2634922(identity) - comment:mint|function:May play a role in the sperm tail fibrous sheath, a major sperm tail structure|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/06/21 2014/10/16 rogid:PwlJ6jhnSpDyw4BnAZtTir0bVbg10090 rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606 intact-crc:E7A316B68DEB28AE|rigid:OBqXrWX6TvKh85coDbJ13UR+qqY false tag:?-?(MINT-2634945)|binding-associated region:504-688(MINT-2634953) binding-associated region:4-400(MINT-2634942)|tag:?-?(MINT-2634935) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6NY15 uniprotkb:Q61221-1 intact:EBI-8549230|uniprotkb:Q68RJ4|intact:MINT-2634910|uniprotkb:Q8K3V2|ensembl:ENSMUSP00000048859 intact:EBI-8549331|ensembl:ENSMUSP00000021530|intact:MINT-2635005 psi-mi:tsg10_mouse(display_long)|uniprotkb:Tsga10(gene name)|psi-mi:Tsga10(display_short) psi-mi:q61221-1(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hägele et al. (2006) pubmed:16777103|imex:IM-10961|mint:MINT-5218745 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8549323|mint:MINT-2634982|imex:IM-10961-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_997111.1|refseq:NP_001277649.1|refseq:NP_001277650.1|ensembl:ENSMUSG00000060771(gene)|ensembl:ENSMUST00000041815(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043005"(neuron projection)|go:"GO:0097228"(sperm principal piece)|interpro:IPR033323|mint:Q6NY15|mint:MINT-2634993(identity) ensembl:ENSMUSG00000021109(gene)|ensembl:ENSMUST00000021530(transcript)|intact:EBI-298954(isoform-parent)|mint:MINT-2634983(identity) - comment:mint|function:May play a role in the sperm tail fibrous sheath, a major sperm tail structure|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/06/21 2014/10/16 rogid:PwlJ6jhnSpDyw4BnAZtTir0bVbg10090 rogid:1jBCL7bIWP7x+b9k/mCB131AQuA10090 intact-crc:66A80E6038FBAD5D|rigid:JxqOOiLZd6xzktTMatcFNBOkVmg false tag:?-?(MINT-2634994)|binding-associated region:504-688(MINT-2635001) binding-associated region:1-401(MINT-2634984)|tag:?-?(MINT-2634988) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6NY15 uniprotkb:Q16665-2 intact:EBI-8549230|uniprotkb:Q68RJ4|intact:MINT-2634910|uniprotkb:Q8K3V2|ensembl:ENSMUSP00000048859 intact:EBI-8549288|intact:MINT-1912478|ensembl:ENSP00000323326 psi-mi:tsg10_mouse(display_long)|uniprotkb:Tsga10(gene name)|psi-mi:Tsga10(display_short) psi-mi:q16665-2(display_long)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)|uniprotkb:MOP1(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hägele et al. (2006) pubmed:16777103|imex:IM-10961|mint:MINT-5218745 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8549280|mint:MINT-2634956|imex:IM-10961-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_997111.1|refseq:NP_001277649.1|refseq:NP_001277650.1|ensembl:ENSMUSG00000060771(gene)|ensembl:ENSMUST00000041815(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043005"(neuron projection)|go:"GO:0097228"(sperm principal piece)|interpro:IPR033323|mint:Q6NY15|mint:MINT-2634957(identity) intact:EBI-447269(isoform-parent)|ensembl:ENSG00000100644(gene)|ensembl:ENST00000323441(transcript)|mint:MINT-2634967(identity) - comment:mint|function:May play a role in the sperm tail fibrous sheath, a major sperm tail structure|comment:"Stoichiometry: 1.0" comment:mint|isoform-comment:No experimental confirmation available. figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/06/21 2014/10/16 rogid:PwlJ6jhnSpDyw4BnAZtTir0bVbg10090 rogid:60VwgZB8UMhSYnQd0kStnEBAbW89606 intact-crc:B41EC571CC3210B5|rigid:awXOXMCTQO89x0c8KL65A1Va0XM false tag:?-?(MINT-2634965)|binding-associated region:504-688(MINT-2634958) binding-associated region:1-341(MINT-2634968)|tag:?-?(MINT-2634975) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q61221-2 uniprotkb:Q6NY15 intact:EBI-8549359|intact:MINT-2635038 intact:EBI-8549230|uniprotkb:Q68RJ4|intact:MINT-2634910|uniprotkb:Q8K3V2|ensembl:ENSMUSP00000048859 psi-mi:q61221-2(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym) psi-mi:tsg10_mouse(display_long)|uniprotkb:Tsga10(gene name)|psi-mi:Tsga10(display_short) psi-mi:"MI:0018"(two hybrid) Hägele et al. (2006) pubmed:16777103|imex:IM-10961|mint:MINT-5218745 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8549367|mint:MINT-2635012|imex:IM-10961-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-298954(isoform-parent)|mint:MINT-2635013(identity) refseq:NP_997111.1|refseq:NP_001277649.1|refseq:NP_001277650.1|ensembl:ENSMUSG00000060771(gene)|ensembl:ENSMUST00000041815(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043005"(neuron projection)|go:"GO:0097228"(sperm principal piece)|interpro:IPR033323|mint:Q6NY15|mint:MINT-2635023(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:May play a role in the sperm tail fibrous sheath, a major sperm tail structure|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/06/21 2014/10/16 rogid:efn+OtM/HRcqf2HqY57wMV3rhiI10090 rogid:PwlJ6jhnSpDyw4BnAZtTir0bVbg10090 intact-crc:50D0E7D7F5124356|rigid:nltehtv4WJZ11Wxkks/Z/FFQj2E false binding-associated region:1-413(MINT-2635014)|tag:?-?(MINT-2635021) binding-associated region:504-688(MINT-2635024)|tag:?-?(MINT-2635031) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q61221-1 uniprotkb:Q6NY15 intact:EBI-8549331|ensembl:ENSMUSP00000021530|intact:MINT-2635005 intact:EBI-8549230|uniprotkb:Q68RJ4|intact:MINT-2634910|uniprotkb:Q8K3V2|ensembl:ENSMUSP00000048859 psi-mi:q61221-1(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym) psi-mi:tsg10_mouse(display_long)|uniprotkb:Tsga10(gene name)|psi-mi:Tsga10(display_short) psi-mi:"MI:0096"(pull down) Hägele et al. (2006) pubmed:16777103|imex:IM-10961|mint:MINT-5218745 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8549446|mint:MINT-2635043|imex:IM-10961-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000021109(gene)|ensembl:ENSMUST00000021530(transcript)|intact:EBI-298954(isoform-parent)|mint:MINT-2635044(identity) refseq:NP_997111.1|refseq:NP_001277649.1|refseq:NP_001277650.1|ensembl:ENSMUSG00000060771(gene)|ensembl:ENSMUST00000041815(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043005"(neuron projection)|go:"GO:0097228"(sperm principal piece)|interpro:IPR033323|mint:Q6NY15|mint:MINT-2635054(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:May play a role in the sperm tail fibrous sheath, a major sperm tail structure|comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/06/21 2014/10/16 rogid:1jBCL7bIWP7x+b9k/mCB131AQuA10090 rogid:PwlJ6jhnSpDyw4BnAZtTir0bVbg10090 intact-crc:87B4B5F3D2A79512|rigid:JxqOOiLZd6xzktTMatcFNBOkVmg false v5 tag:?-?(MINT-2778497)|binding-associated region:1-401(MINT-2635045) binding-associated region:556-688(MINT-2635055)|maltose binding protein tag:?-?(MINT-2635062) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q16665 uniprotkb:Q9BZW7 intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018 intact:EBI-744794|uniprotkb:Q9BWX0|uniprotkb:Q8NEP0|ensembl:ENSP00000347161|ensembl:ENSP00000377123|ensembl:ENSP00000386956|uniprotkb:D3DVH7|uniprotkb:B7Z925 psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym) psi-mi:tsg10_human(display_long)|uniprotkb:CEP4L(gene name synonym)|uniprotkb:Testis development protein NYD-SP7(gene name synonym)|uniprotkb:TSGA10(gene name)|psi-mi:TSGA10(display_short) psi-mi:"MI:0428"(imaging technique) Hägele et al. (2006) pubmed:16777103|imex:IM-10961|mint:MINT-5218745 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8549503|mint:MINT-2635077|imex:IM-10961-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664|mint:MINT-2635087(identity) ensembl:ENSG00000135951(gene)|ensembl:ENST00000355053(transcript)|ensembl:ENST00000393483(transcript)|ensembl:ENST00000410001(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|interpro:IPR033323|mint:Q9BZW7|refseq:XP_011510239.1|refseq:XP_011510241.1|refseq:XP_011510242.1|refseq:XP_011510243.1|refseq:XP_011510244.1|refseq:XP_011510245.1|refseq:NP_079520.1|refseq:NP_878915.2|refseq:XP_016860528.1|refseq:XP_016860529.1|refseq:XP_016860530.1|refseq:XP_016860531.1|refseq:XP_016860532.1|refseq:XP_016860533.1|refseq:XP_016860534.1|refseq:XP_016860535.1|refseq:XP_016860536.1|refseq:XP_016860537.1|refseq:XP_005264080.1|refseq:XP_005264081.1|refseq:XP_005264082.1|refseq:XP_005264083.1|refseq:XP_005264084.1|refseq:XP_005264086.1|refseq:XP_006712844.1|mint:MINT-2635078(identity) - - - figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-spermatozoa)|taxid:9606(Homo sapiens) - 2006/06/21 2014/10/16 rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606 rogid:DwMxOuwQfzz+CNSHN26fw48Gbpk9606 intact-crc:7B6FD3DCB97F7436|rigid:1htsXn3xUnx7+C4nYzkb1QZ8zXk false - - - - psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification)