#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15303	uniprotkb:P78352	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hahn et al. (2006)	imex:IM-14455|pubmed:16767099	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-998522|imex:IM-14455-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	omim:181500(see-also)	-	-	figure legend:Figure 3|comment:The authors note that erbB4 protein interaction with PSD-95 protein is enhanced in schizophrenic subjects.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex)	-	2006/08/24	2014/10/16	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:88BD90A73AD3E5D4|rigid:2lNWW2ms1+/1D4bVEKlK8VzCGvc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05586	uniprotkb:Q15303	intact:EBI-998542|uniprotkb:C9K0X1|uniprotkb:P35437|uniprotkb:Q12867|uniprotkb:Q12868|uniprotkb:A6NLK7|uniprotkb:A6NLR1|uniprotkb:Q5VSF7|uniprotkb:Q5VSF8|uniprotkb:Q5VSF3|uniprotkb:Q5VSF6|ensembl:ENSP00000360616|uniprotkb:Q5VSF4|uniprotkb:Q5VSF5|uniprotkb:Q9UPF8|uniprotkb:Q9UPF9	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	psi-mi:nmdz1_human(display_long)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)|uniprotkb:GRIN1(gene name)|psi-mi:GRIN1(display_short)|uniprotkb:NMDAR1(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hahn et al. (2006)	imex:IM-14455|pubmed:16767099	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-998599|imex:IM-14455-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:Q05586|rcsb pdb:5H8F|rcsb pdb:2HQW|rcsb pdb:5H8H|rcsb pdb:2NR1|rcsb pdb:3BYA|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-3928662|ensembl:ENSG00000176884(gene)|ensembl:ENST00000371561(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_000823.4|refseq:NP_001172019.1|refseq:NP_001172020.1|refseq:NP_015566.1|refseq:NP_067544.1|refseq:XP_005266128.1|refseq:XP_005266130.1	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	omim:181500(see-also)	-	-	figure legend:Supplementary Figure 4 Supplementary Figure 5|comment:The authors note that erbB4 protein interaction with NMDAR protein is enhanced in schizophrenic subjects.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex)	-	2006/08/24	2014/10/16	rogid:k5yQuuGoNYzr955sfuumk22eVvM9606	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	intact-crc:7E57E248985627B2|rigid:xobMAElyfqeh4nddBFk+UFu8Rm0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15303	uniprotkb:P04626	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hahn et al. (2006)	imex:IM-14455|pubmed:16767099	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1008282|imex:IM-14455-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	omim:181500(see-also)	-	-	figure legend:Supplementary Figure 1|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex)	-	2006/08/24	2014/10/16	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:0DB9D4A4CB3E366F|rigid:BXDZFw/v+Oq9TOlJ1AO0N3Ef6SQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05586	uniprotkb:Q15147	intact:EBI-998542|uniprotkb:C9K0X1|uniprotkb:P35437|uniprotkb:Q12867|uniprotkb:Q12868|uniprotkb:A6NLK7|uniprotkb:A6NLR1|uniprotkb:Q5VSF7|uniprotkb:Q5VSF8|uniprotkb:Q5VSF3|uniprotkb:Q5VSF6|ensembl:ENSP00000360616|uniprotkb:Q5VSF4|uniprotkb:Q5VSF5|uniprotkb:Q9UPF8|uniprotkb:Q9UPF9	intact:EBI-998637|uniprotkb:E2QRH8|uniprotkb:Q5JYS9|uniprotkb:Q17R56|uniprotkb:Q5JYS8|uniprotkb:Q5JYT0|uniprotkb:Q5JYT4|uniprotkb:Q9BQW5|uniprotkb:Q9BQW6|uniprotkb:Q9BQW8|uniprotkb:Q9UJQ2|uniprotkb:Q5JYT3|uniprotkb:B7ZLK6|ensembl:ENSP00000278655|ensembl:ENSP00000367754	psi-mi:nmdz1_human(display_long)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)|uniprotkb:GRIN1(gene name)|psi-mi:GRIN1(display_short)|uniprotkb:NMDAR1(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)	psi-mi:plcb4_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-beta-4(gene name synonym)|uniprotkb:Phospholipase C-beta-4(gene name synonym)|uniprotkb:PLCB4(gene name)|psi-mi:PLCB4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hahn et al. (2006)	imex:IM-14455|pubmed:16767099	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-998685|imex:IM-14455-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:Q05586|rcsb pdb:5H8F|rcsb pdb:2HQW|rcsb pdb:5H8H|rcsb pdb:2NR1|rcsb pdb:3BYA|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-3928662|ensembl:ENSG00000176884(gene)|ensembl:ENST00000371561(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_000823.4|refseq:NP_001172019.1|refseq:NP_001172020.1|refseq:NP_015566.1|refseq:NP_067544.1|refseq:XP_005266128.1|refseq:XP_005266130.1	refseq:NP_000924.3|refseq:NP_001166117.1|refseq:NP_877949.2|ensembl:ENSG00000101333(gene)|ensembl:ENST00000278655(transcript)|ensembl:ENST00000378493(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR009535(Protein of unknown function DUF1154)|interpro:IPR011992(EF-Hand type)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|reactome:R-HSA-112043|reactome:R-HSA-1855204|reactome:R-HSA-416476|go:"GO:0098978"(glutamatergic synapse)|refseq:XP_016883369.1|refseq:XP_016883370.1|dip:DIP-36735N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 4|comment:"The authors note that  NMDAR protein and PLCB4 protein interaction was enhanced by NMDA and glycine treatment. However interaction between the proteins was significantly lower in schizophrenic subjects. Even with the relatively small sample size, NRG1  stimulation significantly attenuated PLCB4 recruitment by  NMDAR1 in the schizophrenia group (t(9) = 5.64, P less than 0.001)."|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex)	-	2006/08/24	2014/10/16	rogid:k5yQuuGoNYzr955sfuumk22eVvM9606	rogid:BWQA7ntiUYPN6FhwkGZdCEJfFmE9606	intact-crc:E095C4BE0854CD0A|rigid:9pk6rEvTqTZ2WM171HSfOOlJW0A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)