#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q80TQ2	uniprotkb:Q9Z2F6	intact:EBI-943859|uniprotkb:Q80VB3|uniprotkb:Q8BXZ3|uniprotkb:Q8BYL9|uniprotkb:Q8CGB0|ensembl:ENSMUSP00000105254|ensembl:ENSMUSP00000147426|ensembl:ENSMUSP00000148037	intact:EBI-943884|ensembl:ENSMUSP00000113851	psi-mi:cyld_mouse(display_long)|uniprotkb:Cyld(gene name)|psi-mi:Cyld(display_short)|uniprotkb:Cyld1(gene name synonym)|uniprotkb:Kiaa0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)	psi-mi:bcl3_mouse(display_long)|uniprotkb:Bcl3(gene name)|psi-mi:Bcl3(display_short)	psi-mi:"MI:0018"(two hybrid)	Massoumi et al. (2006)	imex:IM-12034|pubmed:16713561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-943890|imex:IM-12034-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121642.1|refseq:NP_001121643.1|refseq:NP_775545.1|refseq:XP_006531477.1|refseq:XP_006531478.1|refseq:XP_006531479.1|refseq:XP_006531480.1|refseq:XP_006531481.1|refseq:XP_011246825.1|refseq:XP_011246826.1|refseq:XP_011246827.1|refseq:XP_017168478.1|dip:DIP-35656N|ensembl:ENSMUSG00000036712(gene)|ensembl:ENSMUST00000109626(transcript)|ensembl:ENSMUST00000209559(transcript)|ensembl:ENSMUST00000211554(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689880|reactome:R-MMU-936440	refseq:NP_291079.2|ensembl:ENSMUSG00000053175(gene)|ensembl:ENSMUST00000120537(transcript)|go:"GO:0002268"(follicular dendritic cell differentiation)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002467"(germinal center formation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010225"(response to UV-C)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030496"(midbody)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032996"(Bcl3-Bcl10 complex)|go:"GO:0033257"(Bcl3/NF-kappaB2 complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	psi-mi:"MI:0469"(intact)	-	-	figure legend:5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/05	2014/10/16	rogid:U1ditS+hdqob77g9p8v9kSyOKsE10090	rogid:9YpC2b1vDMZI3K2+ah6RlSsB04I10090	intact-crc:2D7EE2E1B63C1DCC|rigid:vpMeqvKHeMnT8ZXJVYiQ2U5PRes	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z2F6	uniprotkb:Q80TQ2	intact:EBI-943884|ensembl:ENSMUSP00000113851	intact:EBI-943859|uniprotkb:Q80VB3|uniprotkb:Q8BXZ3|uniprotkb:Q8BYL9|uniprotkb:Q8CGB0|ensembl:ENSMUSP00000105254|ensembl:ENSMUSP00000147426|ensembl:ENSMUSP00000148037	psi-mi:bcl3_mouse(display_long)|uniprotkb:Bcl3(gene name)|psi-mi:Bcl3(display_short)	psi-mi:cyld_mouse(display_long)|uniprotkb:Cyld(gene name)|psi-mi:Cyld(display_short)|uniprotkb:Cyld1(gene name synonym)|uniprotkb:Kiaa0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Massoumi et al. (2006)	imex:IM-12034|pubmed:16713561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-943896|imex:IM-12034-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_291079.2|ensembl:ENSMUSG00000053175(gene)|ensembl:ENSMUST00000120537(transcript)|go:"GO:0002268"(follicular dendritic cell differentiation)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002467"(germinal center formation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010225"(response to UV-C)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030496"(midbody)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032996"(Bcl3-Bcl10 complex)|go:"GO:0033257"(Bcl3/NF-kappaB2 complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	refseq:NP_001121642.1|refseq:NP_001121643.1|refseq:NP_775545.1|refseq:XP_006531477.1|refseq:XP_006531478.1|refseq:XP_006531479.1|refseq:XP_006531480.1|refseq:XP_006531481.1|refseq:XP_011246825.1|refseq:XP_011246826.1|refseq:XP_011246827.1|refseq:XP_017168478.1|dip:DIP-35656N|ensembl:ENSMUSG00000036712(gene)|ensembl:ENSMUST00000109626(transcript)|ensembl:ENSMUST00000209559(transcript)|ensembl:ENSMUST00000211554(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689880|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/05	2014/10/16	rogid:9YpC2b1vDMZI3K2+ah6RlSsB04I10090	rogid:U1ditS+hdqob77g9p8v9kSyOKsE10090	intact-crc:F86F2E669942FC2C|rigid:vpMeqvKHeMnT8ZXJVYiQ2U5PRes	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q80TQ2	uniprotkb:Q9Z2F6	intact:EBI-943859|uniprotkb:Q80VB3|uniprotkb:Q8BXZ3|uniprotkb:Q8BYL9|uniprotkb:Q8CGB0|ensembl:ENSMUSP00000105254|ensembl:ENSMUSP00000147426|ensembl:ENSMUSP00000148037	intact:EBI-943884|ensembl:ENSMUSP00000113851	psi-mi:cyld_mouse(display_long)|uniprotkb:Cyld(gene name)|psi-mi:Cyld(display_short)|uniprotkb:Cyld1(gene name synonym)|uniprotkb:Kiaa0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)	psi-mi:bcl3_mouse(display_long)|uniprotkb:Bcl3(gene name)|psi-mi:Bcl3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Massoumi et al. (2006)	imex:IM-12034|pubmed:16713561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-943917|imex:IM-12034-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121642.1|refseq:NP_001121643.1|refseq:NP_775545.1|refseq:XP_006531477.1|refseq:XP_006531478.1|refseq:XP_006531479.1|refseq:XP_006531480.1|refseq:XP_006531481.1|refseq:XP_011246825.1|refseq:XP_011246826.1|refseq:XP_011246827.1|refseq:XP_017168478.1|dip:DIP-35656N|ensembl:ENSMUSG00000036712(gene)|ensembl:ENSMUST00000109626(transcript)|ensembl:ENSMUST00000209559(transcript)|ensembl:ENSMUST00000211554(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689880|reactome:R-MMU-936440	refseq:NP_291079.2|ensembl:ENSMUSG00000053175(gene)|ensembl:ENSMUST00000120537(transcript)|go:"GO:0002268"(follicular dendritic cell differentiation)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002467"(germinal center formation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010225"(response to UV-C)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030496"(midbody)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032996"(Bcl3-Bcl10 complex)|go:"GO:0033257"(Bcl3/NF-kappaB2 complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	psi-mi:"MI:0469"(intact)	-	-	figure legend:5C|comment:The cells needed to be stimulated by TPA for atleast 15 min to see the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-skin)|taxid:10090(Mus musculus skin cells)	-	2006/06/05	2014/10/16	rogid:U1ditS+hdqob77g9p8v9kSyOKsE10090	rogid:9YpC2b1vDMZI3K2+ah6RlSsB04I10090	intact-crc:7C0C0F7BE48F4493|rigid:vpMeqvKHeMnT8ZXJVYiQ2U5PRes	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2F6	uniprotkb:Q80TQ2	intact:EBI-943884|ensembl:ENSMUSP00000113851	intact:EBI-943859|uniprotkb:Q80VB3|uniprotkb:Q8BXZ3|uniprotkb:Q8BYL9|uniprotkb:Q8CGB0|ensembl:ENSMUSP00000105254|ensembl:ENSMUSP00000147426|ensembl:ENSMUSP00000148037	psi-mi:bcl3_mouse(display_long)|uniprotkb:Bcl3(gene name)|psi-mi:Bcl3(display_short)	psi-mi:cyld_mouse(display_long)|uniprotkb:Cyld(gene name)|psi-mi:Cyld(display_short)|uniprotkb:Cyld1(gene name synonym)|uniprotkb:Kiaa0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Massoumi et al. (2006)	imex:IM-12034|pubmed:16713561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-943932|imex:IM-12034-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_291079.2|ensembl:ENSMUSG00000053175(gene)|ensembl:ENSMUST00000120537(transcript)|go:"GO:0002268"(follicular dendritic cell differentiation)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002467"(germinal center formation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010225"(response to UV-C)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030496"(midbody)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032996"(Bcl3-Bcl10 complex)|go:"GO:0033257"(Bcl3/NF-kappaB2 complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	refseq:NP_001121642.1|refseq:NP_001121643.1|refseq:NP_775545.1|refseq:XP_006531477.1|refseq:XP_006531478.1|refseq:XP_006531479.1|refseq:XP_006531480.1|refseq:XP_006531481.1|refseq:XP_011246825.1|refseq:XP_011246826.1|refseq:XP_011246827.1|refseq:XP_017168478.1|dip:DIP-35656N|ensembl:ENSMUSG00000036712(gene)|ensembl:ENSMUST00000109626(transcript)|ensembl:ENSMUST00000209559(transcript)|ensembl:ENSMUST00000211554(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689880|reactome:R-MMU-936440	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:5B, S8|comment:The cells needed to be stimulated by TPA for atleast 15 min and UV-B for atleast 30 min to see the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-skin)|taxid:10090(Mus musculus skin cells)	-	2006/06/05	2014/10/16	rogid:9YpC2b1vDMZI3K2+ah6RlSsB04I10090	rogid:U1ditS+hdqob77g9p8v9kSyOKsE10090	intact-crc:934306B4E87C7A89|rigid:vpMeqvKHeMnT8ZXJVYiQ2U5PRes	false	-	green fluorescent protein tag:?-?|fusion protein:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)