#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43745	uniprotkb:P19634	intact:EBI-8525536|intact:MINT-2729920|uniprotkb:A8K2I8|ensembl:ENSP00000300113	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	psi-mi:chp2_human(display_long)|uniprotkb:CHP2(gene name)|psi-mi:CHP2(display_short)|uniprotkb:HCA520(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 520(gene name synonym)	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:"MI:0013"(biophysical)	Ammar et al. (2006)	mint:MINT-5218664|pubmed:16710297|imex:IM-10794	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8525528|mint:MINT-2729935|imex:IM-10794-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071380.1|ensembl:ENSG00000166869(gene)|ensembl:ENST00000300113(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015031"(protein transport)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O43745|rcsb pdb:2BEC|mint:MINT-2729936(identity)	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986|mint:MINT-2729937(identity)	-	comment:mint|function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/27	2014/10/16	rogid:UOhi/gx3k4psrhdl7xbrX/+A8Uo9606	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	intact-crc:E5103EED40D027AF|rigid:xri+F8B5r4C26YtkVcrjBZFKWag	false	his tag:?-?(MINT-2729943)	binding-associated region:503-545(MINT-2729958)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)