#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95433	uniprotkb:P30793	intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym)	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958210|imex:IM-20087-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	intact-crc:2D3B0299F1FF89DE|rigid:RHVNvhVq+NHOtLV5rc+4Hn6u0gk	false	-	sufficient binding region:1-96	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11142	uniprotkb:P30793	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958233|imex:IM-20087-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	intact-crc:BD770F9C07486E29|rigid:JpckrrnHlqQcAJH2kMpWyqfjp+8	false	-	sufficient binding region:1-96	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P30793	uniprotkb:Q9ULW5	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-958239|ensembl:ENSP00000210187|uniprotkb:Q6NXS7|intact:EBI-11079157|uniprotkb:Q3L6K5|uniprotkb:B2RAA6	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:rab26_human(display_long)|uniprotkb:RAB26(gene name)|psi-mi:RAB26(display_short)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958249|imex:IM-20087-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	ensembl:ENSG00000167964(gene)|ensembl:ENST00000210187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|refseq:NP_055168.2|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019002"(GMP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035272"(exocrine system development)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099575"(regulation of protein catabolic process at presynapse, modulating synaptic transmission)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2G6B|reactome:R-HSA-8873719|refseq:NP_001294982.1	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:kcmXxyYkndHxM/lz+XdGXI1qTzY9606	intact-crc:35A3157A66DC4724|rigid:kR00T0avaTlo8q6vZybPoNso0HM	false	sufficient binding region:1-96	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P30793	uniprotkb:Q96F85	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-958255|uniprotkb:B2R4D0|uniprotkb:Q49AN4|uniprotkb:Q9UFZ0|ensembl:ENSP00000263655	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:cnrp1_human(display_long)|uniprotkb:CNRIP1(gene name)|psi-mi:CNRIP1(display_short)|uniprotkb:C2orf32(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958260|imex:IM-20087-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	refseq:NP_001104571.1|refseq:NP_056278.1|refseq:XP_005264306.1|refseq:XP_006712047.1|ensembl:ENSG00000119865(gene)|ensembl:ENST00000263655(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0031718"(type 1 cannabinoid receptor binding)|go:"GO:2000272"(negative regulation of signaling receptor activity)|interpro:IPR029204|mint:Q96F85	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:MDmgQVp/JYXITibIZyBDYtAckUA9606	intact-crc:3D06ECF16D36E8EF|rigid:YnaRNXg0+ZWYYSK0zLS1g0WSJXE	false	sufficient binding region:1-96	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P30793	uniprotkb:Q13129	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-958266|uniprotkb:Q14CQ1|uniprotkb:Q9NU60|ensembl:ENSP00000361857	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:rlf_human(display_long)|uniprotkb:RLF(gene name)|psi-mi:RLF(display_short)|uniprotkb:Rearranged L-myc fusion gene protein(gene name synonym)|uniprotkb:Zn-15-related protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958275|imex:IM-20087-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	refseq:NP_036553.2|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENSG00000117000(gene)|ensembl:ENST00000372771(transcript)	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:nWnF2P2Bh0uPJSAL6a5//1MxOl09606	intact-crc:D7B45B5C16DEFA2B|rigid:0WDB6V7kxuJvkVBtzhQYMH2sU/Y	false	sufficient binding region:1-96	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P30793	uniprotkb:Q02447	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-348158|intact:EBI-28978002|uniprotkb:A0AVL9|uniprotkb:Q69B26|uniprotkb:Q69B27|uniprotkb:Q8TD56|uniprotkb:Q8WWU4|uniprotkb:Q9BQR1|uniprotkb:B4E2B7|ensembl:ENSP00000310301	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:sp3_human(display_long)|uniprotkb:SPR-2(gene name synonym)|uniprotkb:SP3(gene name)|psi-mi:SP3(display_short)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958290|imex:IM-20087-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	refseq:NP_001017371.3|refseq:NP_001166183.1|refseq:NP_003102.1|ensembl:ENSP00000310301|ensembl:ENST00000418194|ensembl:ENSP00000406140|ensembl:ENSG00000172845(gene)|ensembl:ENST00000310015(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016605"(PML body)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030452|interpro:IPR036236|reactome:R-HSA-3232118	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:VXqjICYbtoDWPEw2j4UCNGo7MvU9606	intact-crc:77388BA45A91F4DB|rigid:iKZRkcZx0wiwk6hT2y0JI/RJJBk	false	sufficient binding region:1-96	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O95433	uniprotkb:P30793	intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym)	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958317|imex:IM-20087-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	-	-	-	figure legend:Table 2. Figure 3.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	intact-crc:A8AB30E9D4015861|rigid:RHVNvhVq+NHOtLV5rc+4Hn6u0gk	false	-	necessary binding region:1-42	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30793	uniprotkb:Q96F85	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-958255|uniprotkb:B2R4D0|uniprotkb:Q49AN4|uniprotkb:Q9UFZ0|ensembl:ENSP00000263655	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:cnrp1_human(display_long)|uniprotkb:CNRIP1(gene name)|psi-mi:CNRIP1(display_short)|uniprotkb:C2orf32(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958322|imex:IM-20087-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	refseq:NP_001104571.1|refseq:NP_056278.1|refseq:XP_005264306.1|refseq:XP_006712047.1|ensembl:ENSG00000119865(gene)|ensembl:ENST00000263655(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0031718"(type 1 cannabinoid receptor binding)|go:"GO:2000272"(negative regulation of signaling receptor activity)|interpro:IPR029204|mint:Q96F85	-	-	-	figure legend:Table 2. Figure 3.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:MDmgQVp/JYXITibIZyBDYtAckUA9606	intact-crc:E6BB1479445828EC|rigid:YnaRNXg0+ZWYYSK0zLS1g0WSJXE	false	necessary binding region:1-42	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11142	uniprotkb:P30793	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958327|imex:IM-20087-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	-	-	-	figure legend:Table 2. Figure 3.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	intact-crc:750D9D4FC9480115|rigid:JpckrrnHlqQcAJH2kMpWyqfjp+8	false	-	necessary binding region:1-42	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30793	uniprotkb:Q9ULW5	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-958239|ensembl:ENSP00000210187|uniprotkb:Q6NXS7|intact:EBI-11079157|uniprotkb:Q3L6K5|uniprotkb:B2RAA6	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:rab26_human(display_long)|uniprotkb:RAB26(gene name)|psi-mi:RAB26(display_short)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958332|imex:IM-20087-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	ensembl:ENSG00000167964(gene)|ensembl:ENST00000210187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|refseq:NP_055168.2|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019002"(GMP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035272"(exocrine system development)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099575"(regulation of protein catabolic process at presynapse, modulating synaptic transmission)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2G6B|reactome:R-HSA-8873719|refseq:NP_001294982.1	-	-	-	figure legend:Table 2. Figure 3.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:kcmXxyYkndHxM/lz+XdGXI1qTzY9606	intact-crc:B5DE51E1F52CC136|rigid:kR00T0avaTlo8q6vZybPoNso0HM	false	necessary binding region:1-42	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30793	uniprotkb:Q13129	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-958266|uniprotkb:Q14CQ1|uniprotkb:Q9NU60|ensembl:ENSP00000361857	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:rlf_human(display_long)|uniprotkb:RLF(gene name)|psi-mi:RLF(display_short)|uniprotkb:Rearranged L-myc fusion gene protein(gene name synonym)|uniprotkb:Zn-15-related protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958337|imex:IM-20087-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	refseq:NP_036553.2|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENSG00000117000(gene)|ensembl:ENST00000372771(transcript)	-	-	-	figure legend:Table 2. Figure 3.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:nWnF2P2Bh0uPJSAL6a5//1MxOl09606	intact-crc:DB896D64AD45668D|rigid:0WDB6V7kxuJvkVBtzhQYMH2sU/Y	false	necessary binding region:1-42	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02447	uniprotkb:P30793	intact:EBI-348158|intact:EBI-28978002|uniprotkb:A0AVL9|uniprotkb:Q69B26|uniprotkb:Q69B27|uniprotkb:Q8TD56|uniprotkb:Q8WWU4|uniprotkb:Q9BQR1|uniprotkb:B4E2B7|ensembl:ENSP00000310301	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	psi-mi:sp3_human(display_long)|uniprotkb:SPR-2(gene name synonym)|uniprotkb:SP3(gene name)|psi-mi:SP3(display_short)	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958342|imex:IM-20087-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017371.3|refseq:NP_001166183.1|refseq:NP_003102.1|ensembl:ENSP00000310301|ensembl:ENST00000418194|ensembl:ENSP00000406140|ensembl:ENSG00000172845(gene)|ensembl:ENST00000310015(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016605"(PML body)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030452|interpro:IPR036236|reactome:R-HSA-3232118	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	-	-	-	figure legend:Table 2. Figure 3.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:VXqjICYbtoDWPEw2j4UCNGo7MvU9606	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	intact-crc:46DD234D0AF0D09A|rigid:iKZRkcZx0wiwk6hT2y0JI/RJJBk	false	-	necessary binding region:1-42	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30793	uniprotkb:P30793	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958368|imex:IM-20087-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:Figure 2.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	intact-crc:257EFF6BA2DCB331|rigid:v80NiKW9TcfY1hFRg404ClH9JaM	false	sufficient binding region:96-250	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30047	uniprotkb:P30793	intact:EBI-958385|uniprotkb:Q99749|uniprotkb:Q2M1Q2|uniprotkb:B2R4L6|ensembl:ENSP00000260447|uniprotkb:B7ZLM8	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	psi-mi:gfrp_human(display_long)|uniprotkb:GCHFR(gene name)|psi-mi:GCHFR(display_short)|uniprotkb:GFRP(gene name synonym)|uniprotkb:GTP cyclohydrolase I feedback regulatory protein(gene name synonym)|uniprotkb:p35(gene name synonym)	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958378|imex:IM-20087-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0016597"(amino acid binding)|go:"GO:0030425"(dendrite)|go:"GO:0042133"(neurotransmitter metabolic process)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042470"(melanosome)|go:"GO:0043105"(negative regulation of GTP cyclohydrolase I activity)|go:"GO:0044549"(GTP cyclohydrolase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR009112(GTP cyclohydrolase I, feedback regulatory protein)|interpro:IPR036717|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:7ACC|reactome:R-HSA-1474151|ensembl:ENSG00000137880(gene)|ensembl:ENST00000260447(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|refseq:NP_005249.1	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	-	-	-	figure legend:"Figure 2 (b) and  (c)."|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/20	2014/10/16	rogid:Hkr1UqznwdyXmFYzt3nXhrPSbv89606	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	intact-crc:9EC37808D9EEFE49|rigid:N3yG+zdm2w4J1ig3VcsJBp/2uOQ	false	-	necessary binding region:237-250	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30793	uniprotkb:O95433	intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7	intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479	psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Swick et al. (2006)	pubmed:16696853|imex:IM-20087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-958359|imex:IM-20087-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1	refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)	-	-	-	figure legend:Figure 4|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/20	2014/10/16	rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606	rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606	intact-crc:A871A2F777C032BD|rigid:RHVNvhVq+NHOtLV5rc+4Hn6u0gk	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)