#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O94983 ensembl:ENSRNOG00000008176 intact:EBI-936534|uniprotkb:Q7Z6M8|uniprotkb:Q8N3V0|uniprotkb:Q8NDG4|uniprotkb:Q96G17|uniprotkb:B9EGL0|uniprotkb:D3DTL5|uniprotkb:E7EWU5|intact:EBI-28966798|ensembl:ENSP00000321813 intact:EBI-936494 psi-mi:cmta2_human(display_long)|uniprotkb:CAMTA2(gene name)|psi-mi:CAMTA2(display_short)|uniprotkb:KIAA0909(gene name synonym) psi-mi:anf_rat_gene(display_short)|psi-mi:ENSRNOG00000008176(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Song et al. (2006) imex:IM-11944|pubmed:16678093 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-936559|imex:IM-11944-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) ensembl:ENSP00000321813|ensembl:ENST00000361571|ensembl:ENSP00000354828|ensembl:ENST00000381311|ensembl:ENSP00000370712|ensembl:ENST00000414043|ensembl:ENSP00000412886|refseq:NP_001164637.1|refseq:NP_001164638.1|refseq:NP_001164639.1|refseq:NP_055914.2|ensembl:ENSG00000108509(gene)|ensembl:ENST00000348066(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR005559(CG-1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR036770|interpro:IPR043661 - - - - figure legend:2A|agonist:Association with the promoter was enhanced when coexpressed with Nkx2-5|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2006/05/10 2014/10/16 rogid:wxiAZcGt9lSBNJVPq38lzfgbIgY9606 crc64:5CCB6E9C5A6CCCA5 intact-crc:3F2025B8B5C3EC75 false flag tag:?-? binding-associated region:390-424|binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:O94983 ensembl:ENSRNOG00000008176 intact:EBI-936534|uniprotkb:Q7Z6M8|uniprotkb:Q8N3V0|uniprotkb:Q8NDG4|uniprotkb:Q96G17|uniprotkb:B9EGL0|uniprotkb:D3DTL5|uniprotkb:E7EWU5|intact:EBI-28966798|ensembl:ENSP00000321813 intact:EBI-936494 psi-mi:cmta2_human(display_long)|uniprotkb:CAMTA2(gene name)|psi-mi:CAMTA2(display_short)|uniprotkb:KIAA0909(gene name synonym) psi-mi:anf_rat_gene(display_short)|psi-mi:ENSRNOG00000008176(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Song et al. (2006) imex:IM-11944|pubmed:16678093 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-936548|imex:IM-11944-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) ensembl:ENSP00000321813|ensembl:ENST00000361571|ensembl:ENSP00000354828|ensembl:ENST00000381311|ensembl:ENSP00000370712|ensembl:ENST00000414043|ensembl:ENSP00000412886|refseq:NP_001164637.1|refseq:NP_001164638.1|refseq:NP_001164639.1|refseq:NP_055914.2|ensembl:ENSG00000108509(gene)|ensembl:ENST00000348066(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR005559(CG-1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR036770|interpro:IPR043661 - - - - figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart) - 2006/05/10 2014/10/16 rogid:wxiAZcGt9lSBNJVPq38lzfgbIgY9606 crc64:5CCB6E9C5A6CCCA5 intact-crc:FEE81AAD9E84ED23 false flag tag:?-? binding-associated region:390-424 - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSRNOG00000008176 uniprotkb:P42582 intact:EBI-936494 intact:EBI-297021|ensembl:ENSMUSP00000015723|uniprotkb:P97335 psi-mi:anf_rat_gene(display_short)|psi-mi:ENSRNOG00000008176(display_long) psi-mi:nkx25_mouse(display_long)|uniprotkb:Nkx2-5(gene name)|psi-mi:Nkx2-5(display_short)|uniprotkb:Csx(gene name synonym)|uniprotkb:Nkx-2.5(gene name synonym)|uniprotkb:Nkx2e(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:"MI:0096"(pull down) Song et al. (2006) imex:IM-11944|pubmed:16678093 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-936579|imex:IM-11944-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:5FLV|ensembl:ENSMUSG00000015579(gene)|ensembl:ENSMUST00000015723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003168"(Purkinje myocyte differentiation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003285"(septum secundum development)|go:"GO:0003342"(proepicardium development)|go:"GO:0003350"(pulmonary myocardium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|refseq:NP_032726.1|refseq:XP_006523860.1|dip:DIP-33031N - - - figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 crc64:5CCB6E9C5A6CCCA5 rogid:/U1x7rZvb4/qIpJkF1tQMZ0UF7A10090 intact-crc:D9B0478CC316E79B false biotin tag:?-?|sufficient binding region:390-424 glutathione s tranferase tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) ensembl:ENSRNOG00000008176 uniprotkb:O94983 intact:EBI-936494 intact:EBI-936534|uniprotkb:Q7Z6M8|uniprotkb:Q8N3V0|uniprotkb:Q8NDG4|uniprotkb:Q96G17|uniprotkb:B9EGL0|uniprotkb:D3DTL5|uniprotkb:E7EWU5|intact:EBI-28966798|ensembl:ENSP00000321813 psi-mi:anf_rat_gene(display_short)|psi-mi:ENSRNOG00000008176(display_long) psi-mi:cmta2_human(display_long)|uniprotkb:CAMTA2(gene name)|psi-mi:CAMTA2(display_short)|uniprotkb:KIAA0909(gene name synonym) psi-mi:"MI:0096"(pull down) Song et al. (2006) imex:IM-11944|pubmed:16678093 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-936579|imex:IM-11944-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - ensembl:ENSP00000321813|ensembl:ENST00000361571|ensembl:ENSP00000354828|ensembl:ENST00000381311|ensembl:ENSP00000370712|ensembl:ENST00000414043|ensembl:ENSP00000412886|refseq:NP_001164637.1|refseq:NP_001164638.1|refseq:NP_001164639.1|refseq:NP_055914.2|ensembl:ENSG00000108509(gene)|ensembl:ENST00000348066(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR005559(CG-1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR036770|interpro:IPR043661 - - - figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 crc64:5CCB6E9C5A6CCCA5 rogid:wxiAZcGt9lSBNJVPq38lzfgbIgY9606 intact-crc:D9B0478CC316E79B false biotin tag:?-?|sufficient binding region:390-424 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42582 uniprotkb:O94983 intact:EBI-297021|ensembl:ENSMUSP00000015723|uniprotkb:P97335 intact:EBI-936534|uniprotkb:Q7Z6M8|uniprotkb:Q8N3V0|uniprotkb:Q8NDG4|uniprotkb:Q96G17|uniprotkb:B9EGL0|uniprotkb:D3DTL5|uniprotkb:E7EWU5|intact:EBI-28966798|ensembl:ENSP00000321813 psi-mi:nkx25_mouse(display_long)|uniprotkb:Nkx2-5(gene name)|psi-mi:Nkx2-5(display_short)|uniprotkb:Csx(gene name synonym)|uniprotkb:Nkx-2.5(gene name synonym)|uniprotkb:Nkx2e(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:cmta2_human(display_long)|uniprotkb:CAMTA2(gene name)|psi-mi:CAMTA2(display_short)|uniprotkb:KIAA0909(gene name synonym) psi-mi:"MI:0096"(pull down) Song et al. (2006) imex:IM-11944|pubmed:16678093 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-936627|imex:IM-11944-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:5FLV|ensembl:ENSMUSG00000015579(gene)|ensembl:ENSMUST00000015723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003168"(Purkinje myocyte differentiation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003285"(septum secundum development)|go:"GO:0003342"(proepicardium development)|go:"GO:0003350"(pulmonary myocardium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|refseq:NP_032726.1|refseq:XP_006523860.1|dip:DIP-33031N ensembl:ENSP00000321813|ensembl:ENST00000361571|ensembl:ENSP00000354828|ensembl:ENST00000381311|ensembl:ENSP00000370712|ensembl:ENST00000414043|ensembl:ENSP00000412886|refseq:NP_001164637.1|refseq:NP_001164638.1|refseq:NP_001164639.1|refseq:NP_055914.2|ensembl:ENSG00000108509(gene)|ensembl:ENST00000348066(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR005559(CG-1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR036770|interpro:IPR043661 psi-mi:"MI:0469"(intact) - - figure legend:2B, 3C, 3D|caution:The protein described by the authors is 1196 AA long while the one in the UniProtKB entry is 1202 AA in length. Further the Swissprot sequence update did not include 31 aminoacids originally saved with the entry.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 rogid:/U1x7rZvb4/qIpJkF1tQMZ0UF7A10090 rogid:wxiAZcGt9lSBNJVPq38lzfgbIgY9606 intact-crc:0B13B9073857067F|rigid:uqt1ZKmPpZe/Uchi1cmNWzIOGf4 false glutathione s tranferase tag:n-n 35s radiolabel:?-?|necessary binding region:1-206 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42582 uniprotkb:O94983 intact:EBI-297021|ensembl:ENSMUSP00000015723|uniprotkb:P97335 intact:EBI-936534|uniprotkb:Q7Z6M8|uniprotkb:Q8N3V0|uniprotkb:Q8NDG4|uniprotkb:Q96G17|uniprotkb:B9EGL0|uniprotkb:D3DTL5|uniprotkb:E7EWU5|intact:EBI-28966798|ensembl:ENSP00000321813 psi-mi:nkx25_mouse(display_long)|uniprotkb:Nkx2-5(gene name)|psi-mi:Nkx2-5(display_short)|uniprotkb:Csx(gene name synonym)|uniprotkb:Nkx-2.5(gene name synonym)|uniprotkb:Nkx2e(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:cmta2_human(display_long)|uniprotkb:CAMTA2(gene name)|psi-mi:CAMTA2(display_short)|uniprotkb:KIAA0909(gene name synonym) psi-mi:"MI:0096"(pull down) Song et al. (2006) imex:IM-11944|pubmed:16678093 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-936642|imex:IM-11944-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:5FLV|ensembl:ENSMUSG00000015579(gene)|ensembl:ENSMUST00000015723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003168"(Purkinje myocyte differentiation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003285"(septum secundum development)|go:"GO:0003342"(proepicardium development)|go:"GO:0003350"(pulmonary myocardium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|refseq:NP_032726.1|refseq:XP_006523860.1|dip:DIP-33031N ensembl:ENSP00000321813|ensembl:ENST00000361571|ensembl:ENSP00000354828|ensembl:ENST00000381311|ensembl:ENSP00000370712|ensembl:ENST00000414043|ensembl:ENSP00000412886|refseq:NP_001164637.1|refseq:NP_001164638.1|refseq:NP_001164639.1|refseq:NP_055914.2|ensembl:ENSG00000108509(gene)|ensembl:ENST00000348066(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR005559(CG-1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR036770|interpro:IPR043661 psi-mi:"MI:0469"(intact) - - figure legend:3E, 3F|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 rogid:/U1x7rZvb4/qIpJkF1tQMZ0UF7A10090 rogid:wxiAZcGt9lSBNJVPq38lzfgbIgY9606 intact-crc:7FF54EC42D03AFA5|rigid:uqt1ZKmPpZe/Uchi1cmNWzIOGf4 false glutathione s tranferase tag:n-n|sufficient binding region:137..137-196..196 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94983 uniprotkb:P52952 intact:EBI-936534|uniprotkb:Q7Z6M8|uniprotkb:Q8N3V0|uniprotkb:Q8NDG4|uniprotkb:Q96G17|uniprotkb:B9EGL0|uniprotkb:D3DTL5|uniprotkb:E7EWU5|intact:EBI-28966798|ensembl:ENSP00000321813 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 psi-mi:cmta2_human(display_long)|uniprotkb:CAMTA2(gene name)|psi-mi:CAMTA2(display_short)|uniprotkb:KIAA0909(gene name synonym) psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Song et al. (2006) imex:IM-11944|pubmed:16678093 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-936618|imex:IM-11944-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000321813|ensembl:ENST00000361571|ensembl:ENSP00000354828|ensembl:ENST00000381311|ensembl:ENSP00000370712|ensembl:ENST00000414043|ensembl:ENSP00000412886|refseq:NP_001164637.1|refseq:NP_001164638.1|refseq:NP_001164639.1|refseq:NP_055914.2|ensembl:ENSG00000108509(gene)|ensembl:ENST00000348066(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR005559(CG-1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR036770|interpro:IPR043661 refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 go:"GO:0005634"(nucleus) - - figure legend:2C|comment:CAMTA2 localises to nucleus in the presence of Leptomycin B. Normally the protein localises to cytoplasm and nucleus. Deletion of the N terminal 206 aminoacids results in localisation to the nucleus and deletion of C terminal 80 aminoacids results in cytoplasmic localisation.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2006/05/10 2014/10/16 rogid:wxiAZcGt9lSBNJVPq38lzfgbIgY9606 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 intact-crc:5E9BE4E4B3A4F9F7|rigid:aHF0Z6tZJDcTDMEqKjAtaZHjQQQ false flag tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)