#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P08152 uniprotkb:Q61122 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 intact:EBI-8507625|uniprotkb:Q99J24|intact:MINT-2737045|ensembl:ENSMUSP00000066696 psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:nab1_mouse(display_long)|uniprotkb:Nab1(gene name)|psi-mi:Nab1(display_short)|uniprotkb:EGR-1-binding protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507617|mint:MINT-2737062|imex:IM-10932-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737063(identity) refseq:NP_032693.2|refseq:XP_006495833.1|ensembl:ENSMUSG00000002881(gene)|ensembl:ENSMUST00000069792(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR006986(Nab1, C-terminal)|interpro:IPR006988(Nab, N-terminal)|interpro:IPR006989(Nab, central region)|interpro:IPR038398|interpro:IPR039040|mint:Q61122|mint:MINT-2737064(identity) - comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" comment:mint|function:Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2|comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/03 2014/10/16 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 rogid:8wmD+c5vLgoDo6c2QeqtZYNGThA10090 intact-crc:4ABACF2943A64D62|rigid:botzSi2CkrA9YJtPa+DMJtvjDi8 false tag:?-?(MINT-2737101)|binding-associated region:184-470(MINT-2737108) tag:?-?(MINT-2737071) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P08152 uniprotkb:Q61127 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 intact:EBI-2366420|uniprotkb:Q80VR9|ensembl:ENSMUSP00000026469 psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:nab2_mouse(display_long)|uniprotkb:Nab2(gene name)|psi-mi:Nab2(display_short)|uniprotkb:EGR-1-binding protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507704|mint:MINT-2737112|imex:IM-10932-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737113(identity) refseq:NP_001116367.1|refseq:NP_032694.2|ensembl:ENSMUSG00000025402(gene)|ensembl:ENSMUST00000026469(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016480"(negative regulation of transcription by RNA polymerase III)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|interpro:IPR006988(Nab, N-terminal)|interpro:IPR006989(Nab, central region)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038398|interpro:IPR039040|mint:Q61127|reactome:R-MMU-9031628|mint:MINT-2737123(identity) - comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/03 2014/10/16 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 rogid:rf3ukqRbH6FRLzgfVxvpwEl9Kvc10090 intact-crc:2422F7A56A5FE84C|rigid:5EvDg6yYsivmmNz9PYPx9VPrWj4 false tag:?-?(MINT-2737121)|binding-associated region:184-470(MINT-2737114) tag:?-?(MINT-2737129) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C5D8-1 uniprotkb:P08152 intact:EBI-8064899|ensembl:ENSMUSP00000110425|intact:MINT-2737448 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 psi-mi:q8c5d8-1(display_long)|uniprotkb:Pias2(gene name)|psi-mi:Pias2(display_short)|uniprotkb:Androgen receptor-interacting protein 3(gene name synonym)|uniprotkb:DAB2-interacting protein(gene name synonym)|uniprotkb:Miz1(gene name synonym)|uniprotkb:Msx-interacting zinc finger protein(gene name synonym)|uniprotkb:Piasx(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT x(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS2(gene name synonym)|uniprotkb:Miz1(isoform synonym)|uniprotkb:PIASx-beta(isoform synonym) psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507728|mint:MINT-2737216|imex:IM-10932-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025423(gene)|ensembl:ENSMUST00000114777(transcript)|intact:EBI-6305825(isoform-parent)|mint:MINT-2737217(identity) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737225(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" figure legend:F6|figure legend:F1A|figure legend:F2D|figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/03 2014/10/16 rogid:cdbtERVlS8Tq/izExMTjb0x27P010090 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 intact-crc:F5BBA24FC623DFF0|rigid:z+tLZFx0AjSmDErZO3kRHlvog6s false tag:?-?(MINT-2737220)|binding-associated region:133-162(MINT-2737479) tag:?-?(MINT-2737226)|mutation decreasing interaction:383-383(MINT-2737439)|mutation decreasing interaction:382-382(MINT-2737436)|binding-associated region:329-425(MINT-2737233) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C5D8-1 uniprotkb:P08152 intact:EBI-8064899|ensembl:ENSMUSP00000110425|intact:MINT-2737448 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 psi-mi:q8c5d8-1(display_long)|uniprotkb:Pias2(gene name)|psi-mi:Pias2(display_short)|uniprotkb:Androgen receptor-interacting protein 3(gene name synonym)|uniprotkb:DAB2-interacting protein(gene name synonym)|uniprotkb:Miz1(gene name synonym)|uniprotkb:Msx-interacting zinc finger protein(gene name synonym)|uniprotkb:Piasx(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT x(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS2(gene name synonym)|uniprotkb:Miz1(isoform synonym)|uniprotkb:PIASx-beta(isoform synonym) psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507811|mint:MINT-2737483|imex:IM-10932-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025423(gene)|ensembl:ENSMUST00000114777(transcript)|intact:EBI-6305825(isoform-parent)|mint:MINT-2737485(identity) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737496(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" figure legend:F6|figure legend:F1A|figure legend:F2D|figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/03 2014/10/16 rogid:cdbtERVlS8Tq/izExMTjb0x27P010090 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 intact-crc:9A30FBD569DF4AD2|rigid:z+tLZFx0AjSmDErZO3kRHlvog6s false tag:?-?(MINT-2737494)|binding-associated region:133-162(MINT-2737486) tag:?-?(MINT-2737511)|mutation disrupting interaction:409-409(MINT-2737497)|binding-associated region:329-425(MINT-2737503) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P08152 uniprotkb:O88634 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 intact:EBI-8507883|intact:MINT-2737730|uniprotkb:Q8BZ77|ensembl:ENSMUSP00000054426 psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:par4_mouse(display_long)|uniprotkb:F2rl3(gene name)|psi-mi:F2rl3(display_short)|uniprotkb:Par4(gene name synonym)|uniprotkb:Thrombin receptor-like 3(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507941|mint:MINT-2737742|imex:IM-10932-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737751(identity) refseq:NP_032001.2|dip:DIP-42480N|ensembl:ENSMUSG00000050147(gene)|ensembl:ENSMUST00000058099(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR003944(Protease-activated receptor 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:O88634|rcsb pdb:2PV9|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|mint:MINT-2737743(identity) - comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" comment:mint|function:Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation|comment:"Stoichiometry: 1.0" figure legend:F6|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/03 2014/10/16 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 rogid:rtkvJPLXA8/c4X3wixVRFWXBFpo10090 intact-crc:63D0950C320A71D3|rigid:FXTo2QdVCdz2s2LKJVDDUdlrvDQ false tag:?-?(MINT-2737762)|mutation increasing interaction:409-409(MINT-2737752)|binding-associated region:184-470(MINT-2737758) tag:?-?(MINT-2737746) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O88634 uniprotkb:P08152 intact:EBI-8507883|intact:MINT-2737730|uniprotkb:Q8BZ77|ensembl:ENSMUSP00000054426 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 psi-mi:par4_mouse(display_long)|uniprotkb:F2rl3(gene name)|psi-mi:F2rl3(display_short)|uniprotkb:Par4(gene name synonym)|uniprotkb:Thrombin receptor-like 3(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 3(gene name synonym) psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507908|mint:MINT-2737700|imex:IM-10932-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032001.2|dip:DIP-42480N|ensembl:ENSMUSG00000050147(gene)|ensembl:ENSMUST00000058099(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR003944(Protease-activated receptor 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:O88634|rcsb pdb:2PV9|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|mint:MINT-2737709(identity) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737701(identity) - comment:mint|function:Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" figure legend:F6|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/03 2014/10/16 rogid:rtkvJPLXA8/c4X3wixVRFWXBFpo10090 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 intact-crc:A26D7BC9584FC549|rigid:FXTo2QdVCdz2s2LKJVDDUdlrvDQ false tag:?-?(MINT-2737714) mutation increasing interaction:383-383(MINT-2828860)|binding-associated region:184-470(MINT-2737721)|tag:?-?(MINT-2737704)|mutation increasing interaction:382-382(MINT-2828857) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C5D8-1 uniprotkb:P08152 intact:EBI-8064899|ensembl:ENSMUSP00000110425|intact:MINT-2737448 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 psi-mi:q8c5d8-1(display_long)|uniprotkb:Pias2(gene name)|psi-mi:Pias2(display_short)|uniprotkb:Androgen receptor-interacting protein 3(gene name synonym)|uniprotkb:DAB2-interacting protein(gene name synonym)|uniprotkb:Miz1(gene name synonym)|uniprotkb:Msx-interacting zinc finger protein(gene name synonym)|uniprotkb:Piasx(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT x(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS2(gene name synonym)|uniprotkb:Miz1(isoform synonym)|uniprotkb:PIASx-beta(isoform synonym) psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:"MI:0428"(imaging technique) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8508012|mint:MINT-2737640|imex:IM-10932-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025423(gene)|ensembl:ENSMUST00000114777(transcript)|intact:EBI-6305825(isoform-parent)|mint:MINT-2737641(identity) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737650(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/07/03 2014/10/16 rogid:cdbtERVlS8Tq/izExMTjb0x27P010090 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 intact-crc:726C1D554CF43B78|rigid:z+tLZFx0AjSmDErZO3kRHlvog6s false ha tag:?-?(MINT-2737671) - 1 1 psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification) uniprotkb:Q8C5D8-1 uniprotkb:P08152 intact:EBI-8064899|ensembl:ENSMUSP00000110425|intact:MINT-2737448 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 psi-mi:q8c5d8-1(display_long)|uniprotkb:Pias2(gene name)|psi-mi:Pias2(display_short)|uniprotkb:Androgen receptor-interacting protein 3(gene name synonym)|uniprotkb:DAB2-interacting protein(gene name synonym)|uniprotkb:Miz1(gene name synonym)|uniprotkb:Msx-interacting zinc finger protein(gene name synonym)|uniprotkb:Piasx(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT x(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS2(gene name synonym)|uniprotkb:Miz1(isoform synonym)|uniprotkb:PIASx-beta(isoform synonym) psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:"MI:0096"(pull down) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507979|mint:MINT-2737578|imex:IM-10932-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025423(gene)|ensembl:ENSMUST00000114777(transcript)|intact:EBI-6305825(isoform-parent)|mint:MINT-2737592(identity) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737579(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" figure legend:F1B|figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/03 2014/10/16 rogid:cdbtERVlS8Tq/izExMTjb0x27P010090 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 intact-crc:3C0993292837BF38|rigid:z+tLZFx0AjSmDErZO3kRHlvog6s false binding-associated region:101-286(MINT-2737600) glutathione s tranferase tag:?-?(MINT-2737587) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P08152 uniprotkb:Q8C5D8-1 intact:EBI-7070449|ensembl:ENSMUSP00000041053|intact:MINT-2828823 intact:EBI-8064899|ensembl:ENSMUSP00000110425|intact:MINT-2737448 psi-mi:egr2_mouse(display_long)|uniprotkb:Egr2(gene name)|psi-mi:Egr2(display_short)|uniprotkb:Egr-2(gene name synonym)|uniprotkb:Krox-20(gene name synonym)|uniprotkb:Zfp-25(gene name synonym)|uniprotkb:Zinc finger protein Krox-20(gene name synonym)|uniprotkb:Early growth response protein 2(gene name synonym)|uniprotkb:E3 SUMO-protein transferase ERG2(gene name synonym) psi-mi:q8c5d8-1(display_long)|uniprotkb:Pias2(gene name)|psi-mi:Pias2(display_short)|uniprotkb:Androgen receptor-interacting protein 3(gene name synonym)|uniprotkb:DAB2-interacting protein(gene name synonym)|uniprotkb:Miz1(gene name synonym)|uniprotkb:Msx-interacting zinc finger protein(gene name synonym)|uniprotkb:Piasx(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT x(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS2(gene name synonym)|uniprotkb:Miz1(isoform synonym)|uniprotkb:PIASx-beta(isoform synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Garcia-Dominguez et al. (2006) pubmed:16675951|imex:IM-10932|mint:MINT-5218588 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8508039|mint:MINT-2737675|imex:IM-10932-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001334387.1|refseq:XP_011241670.1|refseq:XP_006513272.1|refseq:XP_006513273.1|refseq:XP_006513274.1|refseq:XP_006513276.1|ensembl:ENSMUSG00000037868(gene)|ensembl:ENSMUST00000048289(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007611"(learning or memory)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010467"(gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021569"(rhombomere 3 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021659"(rhombomere 3 structural organization)|go:"GO:0021660"(rhombomere 3 formation)|go:"GO:0021665"(rhombomere 5 structural organization)|go:"GO:0021666"(rhombomere 5 formation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032868"(response to insulin)|go:"GO:0035284"(brain segmentation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021849|interpro:IPR036236|mint:P08152|reactome:R-MMU-9031628|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|refseq:NP_034248.2|mint:MINT-2737684(identity) ensembl:ENSMUSG00000025423(gene)|ensembl:ENSMUST00000114777(transcript)|intact:EBI-6305825(isoform-parent)|mint:MINT-2737676(identity) - comment:mint|comment:homomint|function:Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/07/03 2014/10/16 rogid:iKWeovUpB1gUsXGstJX/kSanYy410090 rogid:cdbtERVlS8Tq/izExMTjb0x27P010090 intact-crc:CEE4A262BAFAFADC|rigid:z+tLZFx0AjSmDErZO3kRHlvog6s false - ha tag:?-?(MINT-2737681) 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification)