#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03835	uniprotkb:P22149	intact:EBI-22178|uniprotkb:D6VS83|ensemblfungi:YDR098C	intact:EBI-2332|uniprotkb:Q06993|uniprotkb:D6VU71|ensemblfungi:YGL071W	psi-mi:glrx3_yeast(display_long)|uniprotkb:YD8557.05C(orf name)|uniprotkb:GRX3(gene name)|psi-mi:GRX3(display_short)|uniprotkb:YDR098C(locus name)	psi-mi:aft1_yeast(display_long)|uniprotkb:AFT1(gene name)|psi-mi:AFT1(display_short)|uniprotkb:RCS1(gene name synonym)|uniprotkb:Activator of iron transcription protein 1(gene name synonym)|uniprotkb:YGL071W(locus name)	psi-mi:"MI:0018"(two hybrid)	Ojeda et al. (2006)	imex:IM-14464|pubmed:16648636	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-932523|imex:IM-14464-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002505|refseq:NP_010383.4|dip:DIP-1350N|mint:Q03835|ensemblfungi:YDR098C(gene)|ensemblfungi:YDR098C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|rcsb pdb:3D6I|rcsb pdb:5Y4U	refseq:NP_011444.1|sgd:S000003039|dip:DIP-1351N|ensemblfungi:YGL071W(gene)|ensemblfungi:YGL071W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007059"(chromosome segregation)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034758"(positive regulation of iron ion transport)|go:"GO:0036086"(positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR014842(Transcription factor AFT)	psi-mi:"MI:0469"(intact)	crc64:8CC1A04EC1E7DAB3	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/05/02	2015/11/09	rogid:Vjth+XO73fWvOUEPxBfvqKS+V0c559292	rogid:qAjP/tb+zPLL7pj6U2jNaUFXDdE559292	intact-crc:A01555006916580E|rigid:h7TKXoHJWCn+tKdCuOhCH2PXheI	false	mutation disrupting interaction:176-176	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22149	uniprotkb:P32642	intact:EBI-2332|uniprotkb:Q06993|uniprotkb:D6VU71|ensemblfungi:YGL071W	intact:EBI-22211|uniprotkb:D3DM82|ensemblfungi:YER174C	psi-mi:aft1_yeast(display_long)|uniprotkb:AFT1(gene name)|psi-mi:AFT1(display_short)|uniprotkb:RCS1(gene name synonym)|uniprotkb:Activator of iron transcription protein 1(gene name synonym)|uniprotkb:YGL071W(locus name)	psi-mi:glrx4_yeast(display_long)|uniprotkb:GRX4(gene name)|psi-mi:GRX4(display_short)|uniprotkb:SYGP-ORF64(orf name)|uniprotkb:YER174C(locus name)	psi-mi:"MI:0018"(two hybrid)	Ojeda et al. (2006)	imex:IM-14464|pubmed:16648636	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-932535|imex:IM-14464-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011444.1|sgd:S000003039|dip:DIP-1351N|ensemblfungi:YGL071W(gene)|ensemblfungi:YGL071W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007059"(chromosome segregation)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034758"(positive regulation of iron ion transport)|go:"GO:0036086"(positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR014842(Transcription factor AFT)	sgd:S000000976|refseq:NP_011101.3|dip:DIP-6635N|mint:P32642|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|ensemblfungi:YER174C(gene)|ensemblfungi:YER174C_mRNA(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)	psi-mi:"MI:0469"(intact)	-	crc64:86B4C4993545B5B2	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/05/02	2014/10/16	rogid:qAjP/tb+zPLL7pj6U2jNaUFXDdE559292	rogid:S4MmsQAzP0TKwZUjRfjJmugsC1A559292	intact-crc:9F764FD796600A7E|rigid:kixZ1rsM2m6kkNvuZvU204RBtoQ	false	-	mutation disrupting interaction:171-171	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22149	uniprotkb:Q03835	intact:EBI-2332|uniprotkb:Q06993|uniprotkb:D6VU71|ensemblfungi:YGL071W	intact:EBI-22178|uniprotkb:D6VS83|ensemblfungi:YDR098C	psi-mi:aft1_yeast(display_long)|uniprotkb:AFT1(gene name)|psi-mi:AFT1(display_short)|uniprotkb:RCS1(gene name synonym)|uniprotkb:Activator of iron transcription protein 1(gene name synonym)|uniprotkb:YGL071W(locus name)	psi-mi:glrx3_yeast(display_long)|uniprotkb:YD8557.05C(orf name)|uniprotkb:GRX3(gene name)|psi-mi:GRX3(display_short)|uniprotkb:YDR098C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ojeda et al. (2006)	imex:IM-14464|pubmed:16648636	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-932549|imex:IM-14464-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011444.1|sgd:S000003039|dip:DIP-1351N|ensemblfungi:YGL071W(gene)|ensemblfungi:YGL071W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007059"(chromosome segregation)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034758"(positive regulation of iron ion transport)|go:"GO:0036086"(positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR014842(Transcription factor AFT)	sgd:S000002505|refseq:NP_010383.4|dip:DIP-1350N|mint:Q03835|ensemblfungi:YDR098C(gene)|ensemblfungi:YDR098C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|rcsb pdb:3D6I|rcsb pdb:5Y4U	psi-mi:"MI:0469"(intact)	-	crc64:8CC1A04EC1E7DAB3	comment:Tap tagged AFT1 was not coimmunoprecipitated when HIS tagged Grx3 was used in these studies.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/05/02	2015/11/09	rogid:qAjP/tb+zPLL7pj6U2jNaUFXDdE559292	rogid:Vjth+XO73fWvOUEPxBfvqKS+V0c559292	intact-crc:42F8AE89EBD6D60D|rigid:h7TKXoHJWCn+tKdCuOhCH2PXheI	false	calmodulin binding peptide plus protein a tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22149	uniprotkb:P32642	intact:EBI-2332|uniprotkb:Q06993|uniprotkb:D6VU71|ensemblfungi:YGL071W	intact:EBI-22211|uniprotkb:D3DM82|ensemblfungi:YER174C	psi-mi:aft1_yeast(display_long)|uniprotkb:AFT1(gene name)|psi-mi:AFT1(display_short)|uniprotkb:RCS1(gene name synonym)|uniprotkb:Activator of iron transcription protein 1(gene name synonym)|uniprotkb:YGL071W(locus name)	psi-mi:glrx4_yeast(display_long)|uniprotkb:GRX4(gene name)|psi-mi:GRX4(display_short)|uniprotkb:SYGP-ORF64(orf name)|uniprotkb:YER174C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ojeda et al. (2006)	imex:IM-14464|pubmed:16648636	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-932574|imex:IM-14464-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011444.1|sgd:S000003039|dip:DIP-1351N|ensemblfungi:YGL071W(gene)|ensemblfungi:YGL071W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007059"(chromosome segregation)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034758"(positive regulation of iron ion transport)|go:"GO:0036086"(positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR014842(Transcription factor AFT)	sgd:S000000976|refseq:NP_011101.3|dip:DIP-6635N|mint:P32642|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|ensemblfungi:YER174C(gene)|ensemblfungi:YER174C_mRNA(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)	psi-mi:"MI:0469"(intact)	-	crc64:86B4C4993545B5B2	comment:Tap tagged AFT1 was not coimmunoprecipitated when HIS tagged Grx4 was used in these studies.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/05/02	2014/10/16	rogid:qAjP/tb+zPLL7pj6U2jNaUFXDdE559292	rogid:S4MmsQAzP0TKwZUjRfjJmugsC1A559292	intact-crc:371476E8ED292941|rigid:kixZ1rsM2m6kkNvuZvU204RBtoQ	false	calmodulin binding peptide plus protein a tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)