#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3THE2	uniprotkb:P62991	intact:EBI-770040|uniprotkb:Q3TVH2|uniprotkb:Q9CQL8|ensembl:ENSMUSP00000042364|ensembl:ENSMUSP00000156763|ensembl:ENSMUSP00000156883	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:ml12b_mouse(display_long)|uniprotkb:Mrlc2(gene name synonym)|uniprotkb:Myosin regulatory light chain 2-B, smooth muscle isoform(gene name synonym)|uniprotkb:Myl12b(gene name)|psi-mi:Myl12b(display_short)|uniprotkb:Mylc2b(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 20 kDa(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nagano et al. (2006)	pubmed:16619033|imex:IM-11196|mint:MINT-5218527	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8479334|mint:MINT-1953648|imex:IM-11196-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075891.1|dip:DIP-31955N|ensembl:ENSMUSG00000034868(gene)|ensembl:ENSMUSG00000117098(gene)|ensembl:ENSMUST00000038446(transcript)|ensembl:ENSMUST00000233004(transcript)|ensembl:ENSMUST00000233357(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005903"(brush border)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0099738"(cell cortex region)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015070(Region of unknown function DUF1880)|interpro:IPR018247|mint:Q3THE2|reactome:R-MMU-445355|reactome:R-MMU-5627123|mint:MINT-1953649(identity)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K|mint:MINT-1953650(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|figure legend:F3C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2006/05/16	2014/10/16	rogid:5jOP3J5TW0eU9zwalQ2S4Oist4k10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	intact-crc:D6409AC6FB74F653|rigid:JGZDz1kvrvNZ5S6R6ynvSvHU1EM	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BM54	uniprotkb:Q3THE2	intact:EBI-8479415|uniprotkb:Q91Z47|intact:MINT-1953687|uniprotkb:Q8BLY9|uniprotkb:Q3TX01|ensembl:ENSMUSP00000047403	intact:EBI-770040|uniprotkb:Q3TVH2|uniprotkb:Q9CQL8|ensembl:ENSMUSP00000042364|ensembl:ENSMUSP00000156763|ensembl:ENSMUSP00000156883	psi-mi:mylip_mouse(display_long)|uniprotkb:Mylip(gene name)|psi-mi:Mylip(display_short)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain-interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)	psi-mi:ml12b_mouse(display_long)|uniprotkb:Mrlc2(gene name synonym)|uniprotkb:Myosin regulatory light chain 2-B, smooth muscle isoform(gene name synonym)|uniprotkb:Myl12b(gene name)|psi-mi:Myl12b(display_short)|uniprotkb:Mylc2b(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 20 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nagano et al. (2006)	pubmed:16619033|imex:IM-11196|mint:MINT-5218527	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8479456|mint:MINT-1953668|imex:IM-11196-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722484.2|ensembl:ENSMUSG00000038175(gene)|ensembl:ENSMUST00000038275(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|reactome:R-MMU-8866427|reactome:R-MMU-983168|mint:MINT-1953674(identity)	refseq:NP_075891.1|dip:DIP-31955N|ensembl:ENSMUSG00000034868(gene)|ensembl:ENSMUSG00000117098(gene)|ensembl:ENSMUST00000038446(transcript)|ensembl:ENSMUST00000233004(transcript)|ensembl:ENSMUST00000233357(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005903"(brush border)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0099738"(cell cortex region)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015070(Region of unknown function DUF1880)|interpro:IPR018247|mint:Q3THE2|reactome:R-MMU-445355|reactome:R-MMU-5627123|mint:MINT-1953669(identity)	-	comment:mint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2006/05/16	2014/10/16	rogid:epacBO1m2g+868usqQC5BVotyJ410090	rogid:5jOP3J5TW0eU9zwalQ2S4Oist4k10090	intact-crc:817BCD4450806B73|rigid:1wO8Yycuacx+YWdHVktEc5pMuAs	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)