#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99176	uniprotkb:P25604	intact:EBI-18076|uniprotkb:Q02806|uniprotkb:D6VYB7|ensemblfungi:YLR119W	intact:EBI-411625|uniprotkb:D6VR04|uniprotkb:P87010|uniprotkb:P87279|uniprotkb:Q86ZT3|uniprotkb:Q8NIM6|ensemblfungi:YCL008C	psi-mi:srn2_yeast(display_long)|uniprotkb:SRN2(gene name)|psi-mi:SRN2(display_short)|uniprotkb:ESCRT-I complex subunit VPS37(gene name synonym)|uniprotkb:SRN10(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 37(gene name synonym)|uniprotkb:VPS37(gene name synonym)|uniprotkb:L2958(orf name)|uniprotkb:L9233.5(orf name)|uniprotkb:YLR119W(locus name)	psi-mi:stp22_yeast(display_long)|uniprotkb:STP22(gene name)|psi-mi:STP22(display_short)|uniprotkb:VPS23(gene name synonym)|uniprotkb:YCL008C(locus name)|uniprotkb:YCL8C(orf name)|uniprotkb:Vacuolar protein sorting-associated protein 23(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS23(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kostelansky et al. (2006)	imex:IM-12010|pubmed:16615894	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178290|rcsb pdb:2f66|imex:IM-12010-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013220.1|sgd:S000004109|ensemblfungi:YLR119W(gene)|ensemblfungi:YLR119W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR017435(ESCRT-1 complex, Vps37, fungi)|interpro:IPR029012|interpro:IPR037202|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-2130N|mint:Q99176	refseq:NP_009919.3|sgd:S000000514|ensemblfungi:YCL008C(gene)|ensemblfungi:YCL008C_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0061709"(reticulophagy)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|go:"GO:1904669"(ATP export)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|rcsb pdb:1UZX|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2P22|rcsb pdb:3R3Q|rcsb pdb:3R42|reactome:R-SCE-917729|mint:P25604|dip:DIP-5827N	-	crc64:4E99806CED03E345	crc64:FEDE3BE79F063BCE	figure legend:4, table S2|3d-resolution:2.8A|3d-r-factors:working 20.3, free 25.6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:wblVLLKErpKLCkk0FtkAnrWkEFA559292	rogid:8AIy7kppMJG1UCBtqED5LaKVnmk559292	intact-crc:7ADDF55A12C2734D|rigid:jKhHegUeUVKIX8P5K5lF+TBl964	false	sufficient binding region:?-?	sufficient binding region:332-385	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99176	uniprotkb:Q02767	intact:EBI-18076|uniprotkb:Q02806|uniprotkb:D6VYB7|ensemblfungi:YLR119W	intact:EBI-20387|uniprotkb:P87328|uniprotkb:D6W3V0|uniprotkb:E9P8X2|ensemblfungi:YPL065W	psi-mi:srn2_yeast(display_long)|uniprotkb:SRN2(gene name)|psi-mi:SRN2(display_short)|uniprotkb:ESCRT-I complex subunit VPS37(gene name synonym)|uniprotkb:SRN10(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 37(gene name synonym)|uniprotkb:VPS37(gene name synonym)|uniprotkb:L2958(orf name)|uniprotkb:L9233.5(orf name)|uniprotkb:YLR119W(locus name)	psi-mi:vps28_yeast(display_long)|uniprotkb:VPS28(gene name)|psi-mi:VPS28(display_short)|uniprotkb:VPT28(gene name synonym)|uniprotkb:YPL065W(locus name)|uniprotkb:LPE5W(orf name)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kostelansky et al. (2006)	imex:IM-12010|pubmed:16615894	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178290|rcsb pdb:2f66|imex:IM-12010-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013220.1|sgd:S000004109|ensemblfungi:YLR119W(gene)|ensemblfungi:YLR119W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR017435(ESCRT-1 complex, Vps37, fungi)|interpro:IPR029012|interpro:IPR037202|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-2130N|mint:Q99176	refseq:NP_015260.1|sgd:S000005986|ensemblfungi:YPL065W(gene)|ensemblfungi:YPL065W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1904669"(ATP export)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2G3K|rcsb pdb:2J9U|rcsb pdb:2J9V|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-5828N|mint:Q02767	-	crc64:4E99806CED03E345	crc64:DE091D3F60C9D132	figure legend:4, table S2|3d-resolution:2.8A|3d-r-factors:working 20.3, free 25.6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:wblVLLKErpKLCkk0FtkAnrWkEFA559292	rogid:RO7j6SSuuDr3UcxmQoMbXy6ULsA559292	intact-crc:7ADDF55A12C2734D|rigid:jKhHegUeUVKIX8P5K5lF+TBl964	false	sufficient binding region:?-?	sufficient binding region:13-127	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02767	uniprotkb:P25604	intact:EBI-20387|uniprotkb:P87328|uniprotkb:D6W3V0|uniprotkb:E9P8X2|ensemblfungi:YPL065W	intact:EBI-411625|uniprotkb:D6VR04|uniprotkb:P87010|uniprotkb:P87279|uniprotkb:Q86ZT3|uniprotkb:Q8NIM6|ensemblfungi:YCL008C	psi-mi:vps28_yeast(display_long)|uniprotkb:VPS28(gene name)|psi-mi:VPS28(display_short)|uniprotkb:VPT28(gene name synonym)|uniprotkb:YPL065W(locus name)|uniprotkb:LPE5W(orf name)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:stp22_yeast(display_long)|uniprotkb:STP22(gene name)|psi-mi:STP22(display_short)|uniprotkb:VPS23(gene name synonym)|uniprotkb:YCL008C(locus name)|uniprotkb:YCL8C(orf name)|uniprotkb:Vacuolar protein sorting-associated protein 23(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS23(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kostelansky et al. (2006)	imex:IM-12010|pubmed:16615894	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178296|rcsb pdb:2f6m|imex:IM-12010-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015260.1|sgd:S000005986|ensemblfungi:YPL065W(gene)|ensemblfungi:YPL065W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1904669"(ATP export)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2G3K|rcsb pdb:2J9U|rcsb pdb:2J9V|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-5828N|mint:Q02767	refseq:NP_009919.3|sgd:S000000514|ensemblfungi:YCL008C(gene)|ensemblfungi:YCL008C_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0061709"(reticulophagy)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|go:"GO:1904669"(ATP export)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|rcsb pdb:1UZX|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2P22|rcsb pdb:3R3Q|rcsb pdb:3R42|reactome:R-SCE-917729|mint:P25604|dip:DIP-5827N	-	crc64:DE091D3F60C9D132	crc64:FEDE3BE79F063BCE	figure legend:2, table S2|3d-resolution:2.1A|3d-r-factors:working 24.1, free 26.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:RO7j6SSuuDr3UcxmQoMbXy6ULsA559292	rogid:8AIy7kppMJG1UCBtqED5LaKVnmk559292	intact-crc:5EF6A0B8A261E75E|rigid:+/mz13JHCJP7kFe06XaQc06+jA8	false	sufficient binding region:13-127	sufficient binding region:322-385	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99176	uniprotkb:P25604	intact:EBI-18076|uniprotkb:Q02806|uniprotkb:D6VYB7|ensemblfungi:YLR119W	intact:EBI-411625|uniprotkb:D6VR04|uniprotkb:P87010|uniprotkb:P87279|uniprotkb:Q86ZT3|uniprotkb:Q8NIM6|ensemblfungi:YCL008C	psi-mi:srn2_yeast(display_long)|uniprotkb:SRN2(gene name)|psi-mi:SRN2(display_short)|uniprotkb:ESCRT-I complex subunit VPS37(gene name synonym)|uniprotkb:SRN10(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 37(gene name synonym)|uniprotkb:VPS37(gene name synonym)|uniprotkb:L2958(orf name)|uniprotkb:L9233.5(orf name)|uniprotkb:YLR119W(locus name)	psi-mi:stp22_yeast(display_long)|uniprotkb:STP22(gene name)|psi-mi:STP22(display_short)|uniprotkb:VPS23(gene name synonym)|uniprotkb:YCL008C(locus name)|uniprotkb:YCL8C(orf name)|uniprotkb:Vacuolar protein sorting-associated protein 23(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS23(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Kostelansky et al. (2006)	imex:IM-12010|pubmed:16615894	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178357|imex:IM-12010-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013220.1|sgd:S000004109|ensemblfungi:YLR119W(gene)|ensemblfungi:YLR119W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR017435(ESCRT-1 complex, Vps37, fungi)|interpro:IPR029012|interpro:IPR037202|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-2130N|mint:Q99176	refseq:NP_009919.3|sgd:S000000514|ensemblfungi:YCL008C(gene)|ensemblfungi:YCL008C_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0061709"(reticulophagy)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|go:"GO:1904669"(ATP export)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|rcsb pdb:1UZX|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2P22|rcsb pdb:3R3Q|rcsb pdb:3R42|reactome:R-SCE-917729|mint:P25604|dip:DIP-5827N	go:"GO:0000813"(ESCRT I complex)	crc64:4E99806CED03E345	crc64:FEDE3BE79F063BCE	figure legend:1A, 1B|complex-properties:The above complex yeilded a predominant peak with apparent MW of 190 kDa.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:wblVLLKErpKLCkk0FtkAnrWkEFA559292	rogid:8AIy7kppMJG1UCBtqED5LaKVnmk559292	intact-crc:702881D195694E80|rigid:jKhHegUeUVKIX8P5K5lF+TBl964	false	-	sufficient binding region:162-385	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99176	uniprotkb:Q02767	intact:EBI-18076|uniprotkb:Q02806|uniprotkb:D6VYB7|ensemblfungi:YLR119W	intact:EBI-20387|uniprotkb:P87328|uniprotkb:D6W3V0|uniprotkb:E9P8X2|ensemblfungi:YPL065W	psi-mi:srn2_yeast(display_long)|uniprotkb:SRN2(gene name)|psi-mi:SRN2(display_short)|uniprotkb:ESCRT-I complex subunit VPS37(gene name synonym)|uniprotkb:SRN10(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 37(gene name synonym)|uniprotkb:VPS37(gene name synonym)|uniprotkb:L2958(orf name)|uniprotkb:L9233.5(orf name)|uniprotkb:YLR119W(locus name)	psi-mi:vps28_yeast(display_long)|uniprotkb:VPS28(gene name)|psi-mi:VPS28(display_short)|uniprotkb:VPT28(gene name synonym)|uniprotkb:YPL065W(locus name)|uniprotkb:LPE5W(orf name)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Kostelansky et al. (2006)	imex:IM-12010|pubmed:16615894	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178357|imex:IM-12010-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013220.1|sgd:S000004109|ensemblfungi:YLR119W(gene)|ensemblfungi:YLR119W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR017435(ESCRT-1 complex, Vps37, fungi)|interpro:IPR029012|interpro:IPR037202|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-2130N|mint:Q99176	refseq:NP_015260.1|sgd:S000005986|ensemblfungi:YPL065W(gene)|ensemblfungi:YPL065W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1904669"(ATP export)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2G3K|rcsb pdb:2J9U|rcsb pdb:2J9V|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-5828N|mint:Q02767	go:"GO:0000813"(ESCRT I complex)	crc64:4E99806CED03E345	crc64:DE091D3F60C9D132	figure legend:1A, 1B|complex-properties:The above complex yeilded a predominant peak with apparent MW of 190 kDa.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:wblVLLKErpKLCkk0FtkAnrWkEFA559292	rogid:RO7j6SSuuDr3UcxmQoMbXy6ULsA559292	intact-crc:702881D195694E80|rigid:jKhHegUeUVKIX8P5K5lF+TBl964	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99176	uniprotkb:P25604	intact:EBI-18076|uniprotkb:Q02806|uniprotkb:D6VYB7|ensemblfungi:YLR119W	intact:EBI-411625|uniprotkb:D6VR04|uniprotkb:P87010|uniprotkb:P87279|uniprotkb:Q86ZT3|uniprotkb:Q8NIM6|ensemblfungi:YCL008C	psi-mi:srn2_yeast(display_long)|uniprotkb:SRN2(gene name)|psi-mi:SRN2(display_short)|uniprotkb:ESCRT-I complex subunit VPS37(gene name synonym)|uniprotkb:SRN10(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 37(gene name synonym)|uniprotkb:VPS37(gene name synonym)|uniprotkb:L2958(orf name)|uniprotkb:L9233.5(orf name)|uniprotkb:YLR119W(locus name)	psi-mi:stp22_yeast(display_long)|uniprotkb:STP22(gene name)|psi-mi:STP22(display_short)|uniprotkb:VPS23(gene name synonym)|uniprotkb:YCL008C(locus name)|uniprotkb:YCL8C(orf name)|uniprotkb:Vacuolar protein sorting-associated protein 23(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS23(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Kostelansky et al. (2006)	imex:IM-12010|pubmed:16615894	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178397|imex:IM-12010-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013220.1|sgd:S000004109|ensemblfungi:YLR119W(gene)|ensemblfungi:YLR119W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR017435(ESCRT-1 complex, Vps37, fungi)|interpro:IPR029012|interpro:IPR037202|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-2130N|mint:Q99176	refseq:NP_009919.3|sgd:S000000514|ensemblfungi:YCL008C(gene)|ensemblfungi:YCL008C_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0061709"(reticulophagy)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|go:"GO:1904669"(ATP export)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|rcsb pdb:1UZX|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2P22|rcsb pdb:3R3Q|rcsb pdb:3R42|reactome:R-SCE-917729|mint:P25604|dip:DIP-5827N	go:"GO:0000813"(ESCRT I complex)	crc64:4E99806CED03E345	crc64:FEDE3BE79F063BCE	figure legend:1C, 1D, 1F|complex-properties:"The above complex exist as two species having sedimentation coefficients of 3.6 and 4.8S. Monomeric 1:1:1 ternary complex with Molecular weight of 78 kDa is the major species with a dimeric state also observed."|kinetics:Modeling the equilibrium data to a monomerdimer mixture yielded excellent fits a dissociation constant constant Kd of 110-160 micromoles.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:wblVLLKErpKLCkk0FtkAnrWkEFA559292	rogid:8AIy7kppMJG1UCBtqED5LaKVnmk559292	intact-crc:516A507396A03790|rigid:jKhHegUeUVKIX8P5K5lF+TBl964	false	-	sufficient binding region:162-385	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99176	uniprotkb:Q02767	intact:EBI-18076|uniprotkb:Q02806|uniprotkb:D6VYB7|ensemblfungi:YLR119W	intact:EBI-20387|uniprotkb:P87328|uniprotkb:D6W3V0|uniprotkb:E9P8X2|ensemblfungi:YPL065W	psi-mi:srn2_yeast(display_long)|uniprotkb:SRN2(gene name)|psi-mi:SRN2(display_short)|uniprotkb:ESCRT-I complex subunit VPS37(gene name synonym)|uniprotkb:SRN10(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 37(gene name synonym)|uniprotkb:VPS37(gene name synonym)|uniprotkb:L2958(orf name)|uniprotkb:L9233.5(orf name)|uniprotkb:YLR119W(locus name)	psi-mi:vps28_yeast(display_long)|uniprotkb:VPS28(gene name)|psi-mi:VPS28(display_short)|uniprotkb:VPT28(gene name synonym)|uniprotkb:YPL065W(locus name)|uniprotkb:LPE5W(orf name)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Kostelansky et al. (2006)	imex:IM-12010|pubmed:16615894	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178397|imex:IM-12010-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013220.1|sgd:S000004109|ensemblfungi:YLR119W(gene)|ensemblfungi:YLR119W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR017435(ESCRT-1 complex, Vps37, fungi)|interpro:IPR029012|interpro:IPR037202|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-2130N|mint:Q99176	refseq:NP_015260.1|sgd:S000005986|ensemblfungi:YPL065W(gene)|ensemblfungi:YPL065W_mRNA(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1904669"(ATP export)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|rcsb pdb:2CAZ|rcsb pdb:2F66|rcsb pdb:2F6M|rcsb pdb:2G3K|rcsb pdb:2J9U|rcsb pdb:2J9V|rcsb pdb:2P22|reactome:R-SCE-917729|dip:DIP-5828N|mint:Q02767	go:"GO:0000813"(ESCRT I complex)	crc64:4E99806CED03E345	crc64:DE091D3F60C9D132	figure legend:1C, 1D, 1F|complex-properties:"The above complex exist as two species having sedimentation coefficients of 3.6 and 4.8S. Monomeric 1:1:1 ternary complex with Molecular weight of 78 kDa is the major species with a dimeric state also observed."|kinetics:Modeling the equilibrium data to a monomerdimer mixture yielded excellent fits a dissociation constant constant Kd of 110-160 micromoles.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:wblVLLKErpKLCkk0FtkAnrWkEFA559292	rogid:RO7j6SSuuDr3UcxmQoMbXy6ULsA559292	intact-crc:516A507396A03790|rigid:jKhHegUeUVKIX8P5K5lF+TBl964	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)