#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-1179609	uniprotkb:O41094	-	intact:EBI-1179574	psi-mi:h3_peptide-4(display_short)|psi-mi:EBI-1179609(display_long)	psi-mi:o41094_pbcv1(display_long)|uniprotkb:A612L(gene name)|psi-mi:A612L(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Qian et al. (2006)	pubmed:16603186|imex:IM-19509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10506(pbcv1)|taxid:10506("Paramecium bursaria Chlorella virus 1 (PBCV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1179546|rcsb pdb:2G46|imex:IM-19509-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	uniprotkb:P68433(see-also)|uniprotkb:Q71DI3(see-also)	refseq:NP_048968.1|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR001214(SET)|interpro:IPR009207(Histone methyltransferase, PBCV type putative)|rcsb pdb:1N3J|rcsb pdb:2G46|rcsb pdb:3KMA|rcsb pdb:3KMJ|rcsb pdb:3KMT|dip:DIP-36309N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:1, 2 and table 1|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/18	2014/10/16	rogid:OmIsae0Sg/lBwfokPJEMHCPOfzI-2	rogid:gEPUwbfQlpvZauojwYArtfdwUf410506	intact-crc:571DC77BE638C1B0	false	N6-methyl-L-lysine:14-14	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16680"	intact:EBI-1179609	intact:EBI-1180228	-	psi-mi:s-adenosyl-l-homocysteine(display_short)|psi-mi:"CHEBI:16680"(display_long)	psi-mi:h3_peptide-4(display_short)|psi-mi:EBI-1179609(display_long)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Qian et al. (2006)	pubmed:16603186|imex:IM-19509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1179546|rcsb pdb:2G46|imex:IM-19509-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	uniprotkb:P68433(see-also)|uniprotkb:Q71DI3(see-also)	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:1, 2 and table 1|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/18	2014/10/16	-	rogid:OmIsae0Sg/lBwfokPJEMHCPOfzI-2	intact-crc:571DC77BE638C1B0	false	-	N6-methyl-L-lysine:14-14	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O41094	intact:EBI-1179609	intact:EBI-1179574	-	psi-mi:o41094_pbcv1(display_long)|uniprotkb:A612L(gene name)|psi-mi:A612L(display_short)	psi-mi:h3_peptide-4(display_short)|psi-mi:EBI-1179609(display_long)	psi-mi:"MI:0515"(methyltransferase assay)	Qian et al. (2006)	pubmed:16603186|imex:IM-19509	taxid:10506(pbcv1)|taxid:10506("Paramecium bursaria Chlorella virus 1 (PBCV-1)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182955|imex:IM-19509-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_048968.1|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR001214(SET)|interpro:IPR009207(Histone methyltransferase, PBCV type putative)|rcsb pdb:1N3J|rcsb pdb:2G46|rcsb pdb:3KMA|rcsb pdb:3KMJ|rcsb pdb:3KMT|dip:DIP-36309N	uniprotkb:P68433(see-also)|uniprotkb:Q71DI3(see-also)	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:5, 6|resulting-ptm:Mono, di and tri methylation are observed by Mass spectrometry.|kinetics:Mono, di and tri-methylation of a H3-K27 peptide had rate constants of 0.047 per min, 0.015 per min and 0.005 per min, respectively. Over all Kcat of 1.32 per sec was observed.|comment:Tyr50Phe mutation became largely a mono-methylase for H3-K27 with little, if any, di or tri-methylation activity. Phe52Tyr can only mono and di but not tri-methylate H3-K27.|kinetics:Y50F mutation did not affect the mono-methylation with the apparent kinetic parameters being Km of 427.4 MicroMoles and kcat of 1.36 per sec. Kinetic parameters for F52Y were reaction rate of 3.9 MicroMoles.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/18	2014/10/16	rogid:gEPUwbfQlpvZauojwYArtfdwUf410506	rogid:OmIsae0Sg/lBwfokPJEMHCPOfzI-2	intact-crc:8D5127D2CF1E33F3|rigid:ZLhaNvEqzWsoNIOv6jHpz+oazwk	false	mutation disrupting interaction:50-50|mutation disrupting interaction:51-51|mutation decreasing interaction:50-50|mutation decreasing interaction:52-52|mutation disrupting interaction:78-78|mutation disrupting interaction:78-78	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)