#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BPZ3 uniprotkb:P11940 intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6 intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004 psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name) psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yoshida et al. (2006) pubmed:16601676|imex:IM-11479|mint:MINT-5218475 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8295621|mint:MINT-1899153|imex:IM-11479-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1|mint:MINT-1899160(identity) interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N|mint:MINT-1899154(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2006/05/11 2014/10/16 rogid:g8odIyznsg186nI0YTU30fzY+yQ9606 rogid:XudTSPq2h9ckKAc48X88RVafPRU9606 intact-crc:F73F0CD9E59AB4DD|rigid:T7+hxy/zhUudx2Rr5A7ms3OltGQ false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:O95071 uniprotkb:Q9BPZ3 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6 psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yoshida et al. (2006) pubmed:16601676|imex:IM-11479|mint:MINT-5218475 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8295635|mint:MINT-1899175|imex:IM-11479-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N|mint:MINT-1899176(identity) ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1|mint:MINT-1899182(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5A|comment:Endogenous EDD was precipitated with anti-Paip2 antibody only in the PABP-depleted cell extract.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2006/05/11 2014/10/16 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 rogid:g8odIyznsg186nI0YTU30fzY+yQ9606 intact-crc:13AFC9A9F6101CC1|rigid:YwZsFRa8MVw8LJnenMyYHjgz098 false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:O95071 uniprotkb:Q9BPZ3 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6 psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name) psi-mi:"MI:0077"(nuclear magnetic resonance) Yoshida et al. (2006) pubmed:16601676|imex:IM-11479|mint:MINT-5218475 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8295682|mint:MINT-1899195|imex:IM-11479-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N|mint:MINT-1899196(identity) ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1|mint:MINT-1899202(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5B|figure legend:F5C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/11 2014/10/16 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 rogid:g8odIyznsg186nI0YTU30fzY+yQ9606 intact-crc:4A97A0EDE96810BF|rigid:YwZsFRa8MVw8LJnenMyYHjgz098 false binding-associated region:2393-2452(MINT-1899216) binding-associated region:106-127(MINT-1899213) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9BPZ3 uniprotkb:O95071 intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name) psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Yoshida et al. (2006) pubmed:16601676|imex:IM-11479|mint:MINT-5218475 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8295718|mint:MINT-1899220|imex:IM-11479-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1|mint:MINT-1899229(identity) refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N|mint:MINT-1899221(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5D|kinetics:kd 8.8 micromolar|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/11 2014/10/16 rogid:g8odIyznsg186nI0YTU30fzY+yQ9606 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 intact-crc:A6C5378A85A14BEE|rigid:YwZsFRa8MVw8LJnenMyYHjgz098 false binding-associated region:106-127(MINT-1899230) binding-associated region:2393-2452(MINT-1899222) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9BPZ3 uniprotkb:O95071 intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name) psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:"MI:0415"(enzymatic study) Yoshida et al. (2006) pubmed:16601676|imex:IM-11479|mint:MINT-5218475 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0220"(ubiquitination reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8295754|mint:MINT-1899264|imex:IM-11479-3 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1|mint:MINT-1899273(identity) refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N|mint:MINT-1899265(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6A|kinetics:kd 6.0 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/11 2014/10/16 rogid:g8odIyznsg186nI0YTU30fzY+yQ9606 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 intact-crc:E10C20FB195AB08D|rigid:YwZsFRa8MVw8LJnenMyYHjgz098 false glutathione s tranferase tag:?-?(MINT-1899282) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q59EM9 uniprotkb:Q9BPZ3 intact:EBI-7973868|intact:MINT-1378079 intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6 psi-mi:q59em9_human(display_long) psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name) psi-mi:"MI:0096"(pull down) Yoshida et al. (2006) pubmed:16601676|imex:IM-11479|mint:MINT-5218475 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8295825|mint:MINT-1899128|imex:IM-11479-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:Q59EM9|interpro:IPR000626(Ubiquitin)|mint:MINT-1899129(identity) ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1|mint:MINT-1899130(identity) - comment:"fragmentation type: fragment"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2006/05/11 2014/10/16 rogid:TUO8wSmvSPs8zyZQFqkq3Rfxw/c9606 rogid:g8odIyznsg186nI0YTU30fzY+yQ9606 intact-crc:CC99DA788FC9698C|rigid:Lr2UUtG1hp55xRSwzIPUNFcG5Qw false his tag:?-?(MINT-1899139) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9BPZ3 uniprotkb:O95071 intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name) psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Yoshida et al. (2006) pubmed:16601676|imex:IM-11479|mint:MINT-5218475 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8295873|mint:MINT-1899242|imex:IM-11479-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1|mint:MINT-1899243(identity) refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N|mint:MINT-1899250(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5E|kinetics:kd 6.0 micromolar|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/11 2014/10/16 rogid:g8odIyznsg186nI0YTU30fzY+yQ9606 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 intact-crc:F8730DA5D19553E9|rigid:YwZsFRa8MVw8LJnenMyYHjgz098 false binding-associated region:106-127(MINT-1899248) binding-associated region:2393-2452(MINT-1899255) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)