#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JI18	uniprotkb:P11835	intact:EBI-8294317|intact:MINT-1951413|uniprotkb:Q8BZM7|uniprotkb:Q8BZD3	intact:EBI-644501|uniprotkb:Q64482	psi-mi:lrp1b_mouse(display_long)|uniprotkb:Lrp1b(gene name)|psi-mi:Lrp1b(display_short)|uniprotkb:Lrpdit(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein-deleted in tumor(gene name synonym)	psi-mi:itb2_mouse(display_long)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:Itgb2(gene name)|psi-mi:Itgb2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Cao et al. (2006)	pubmed:16601674|imex:IM-10833|mint:MINT-5218472	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8294308|mint:MINT-1951491|imex:IM-10833-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032485|interpro:IPR018097|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR023415|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR026823|interpro:IPR036055|mint:Q9JI18|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|mint:MINT-1951497(identity)	refseq:NP_032430.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990266"(neutrophil migration)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|reactome:R-MMU-166016|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-37428N|mint:P11835|mint:MINT-1951492(identity)	-	comment:mint|function:Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6B|figure legend:F6C|comment:Addition of RAP or genetic inactivation of PAI-1 or tPA  significantly reduced LRP/Mac-1 colocalization in the trailing  edges|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2006/05/15	2014/10/16	rogid:nsQ23JZaoGnGFCJ7ConZRTVHMSM10090	rogid:a6PSt0Keij+/xNNHH2GNomc28SM10090	intact-crc:C96F321E63399B0A|rigid:uskWhElS5vQu42hnWSEgLF5FQgg	false	-	-	1	1	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9JI18	uniprotkb:P11835	intact:EBI-8294317|intact:MINT-1951413|uniprotkb:Q8BZM7|uniprotkb:Q8BZD3	intact:EBI-644501|uniprotkb:Q64482	psi-mi:lrp1b_mouse(display_long)|uniprotkb:Lrp1b(gene name)|psi-mi:Lrp1b(display_short)|uniprotkb:Lrpdit(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein-deleted in tumor(gene name synonym)	psi-mi:itb2_mouse(display_long)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:Itgb2(gene name)|psi-mi:Itgb2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cao et al. (2006)	pubmed:16601674|imex:IM-10833|mint:MINT-5218472	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8294365|mint:MINT-1951458|imex:IM-10833-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032485|interpro:IPR018097|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR023415|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR026823|interpro:IPR036055|mint:Q9JI18|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|mint:MINT-1951460(identity)	refseq:NP_032430.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990266"(neutrophil migration)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|reactome:R-MMU-166016|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-37428N|mint:P11835|mint:MINT-1951459(identity)	-	comment:mint|function:Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4D|figure legend:F4E|comment:In macrophages obtained from PAI1-/- or tPA-/- mice only small amounts of the LRP/Mac-1 complex could be detected|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2006/05/15	2014/10/16	rogid:nsQ23JZaoGnGFCJ7ConZRTVHMSM10090	rogid:a6PSt0Keij+/xNNHH2GNomc28SM10090	intact-crc:023834A9F32A8D49|rigid:uskWhElS5vQu42hnWSEgLF5FQgg	false	-	-	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)