#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DPI0	uniprotkb:Q9Z2I6	intact:EBI-8178893|uniprotkb:P18639|intact:MINT-1795451|uniprotkb:P01561|uniprotkb:A5HZZ9|uniprotkb:A7G1U9|uniprotkb:P10845	intact:EBI-8178859|intact:MINT-1795475|ensembl:ENSRNOP00000024459	psi-mi:bxa1_clobo(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:atx(gene name synonym)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:Botulinum neurotoxin type A1(gene name synonym)|uniprotkb:bonT(gene name synonym)	psi-mi:sv2c_rat(display_long)|uniprotkb:Sv2c(gene name)|psi-mi:Sv2c(display_short)	psi-mi:"MI:0096"(pull down)	Mahrhold et al. (2006)	pubmed:16545378|imex:IM-13944|mint:MINT-5218441	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178884|mint:MINT-1795489|imex:IM-13944-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JRA|rcsb pdb:5JLV|rcsb pdb:5JMC|rcsb pdb:6XCB|rcsb pdb:6XCC|rcsb pdb:6XCE|rcsb pdb:6XCF|rcsb pdb:6DKK|rcsb pdb:6MHJ|rcsb pdb:2ISG|rcsb pdb:2IMC|rcsb pdb:2ILP|rcsb pdb:2IMA|rcsb pdb:2VUA|rcsb pdb:1UEE|rcsb pdb:4HEV|rcsb pdb:3V0C|rcsb pdb:2ISH|rcsb pdb:1XTF|rcsb pdb:2VU9|rcsb pdb:3ZUS|rcsb pdb:3BOO|rcsb pdb:1XTG|rcsb pdb:2ISE|rcsb pdb:2IMB|rcsb pdb:3BOK|rcsb pdb:2W2D|rcsb pdb:3V0B|rcsb pdb:3V0A|rcsb pdb:3BON|rcsb pdb:3ZUR|rcsb pdb:4IQP|rcsb pdb:5MK6|rcsb pdb:5MK7|rcsb pdb:5TPB|rcsb pdb:5TPC|rcsb pdb:5VGV|rcsb pdb:5VGX|rcsb pdb:5V8P|rcsb pdb:5V8R|rcsb pdb:5V8U|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|refseq:WP_003356619.1|refseq:WP_011948511.1|reactome:R-HSA-5250968|rcsb pdb:6XCD|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044156"(host cell junction)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044231"(host cell presynaptic membrane)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0090729"(toxin activity)|go:"GO:1905576"(ganglioside GT1b binding)|mint:MINT-1795490(identity)	rcsb pdb:5JMC|refseq:XP_017446285.1|refseq:NP_113781.1|rgd:619718|ensembl:ENSRNOG00000018094(gene)|ensembl:ENSRNOT00000024459(transcript)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0043005"(neuron projection)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:MINT-1795491(identity)	-	comment:mint|function:"Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure"|comment:"Stoichiometry: 1.0"	comment:mint|function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles|function:Receptor for the botulinium neurotoxin type A/BOTA|comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1C|figure legend:F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2014/10/16	rogid:15Vc5B8nPpFHrwDzDcAWGGZaryk1491	rogid:ndr8X1sl1ne8Knc4Hcpv24uqsHA10116	intact-crc:0FD86D9D56576B5C|rigid:WvFS7Cs/7eb772+sTlq0INsXCPc	false	binding-associated region:448-1295(MINT-1795511)|tag:?-?(MINT-1795505)	binding-associated region:454-603(MINT-1795502)|glutathione s tranferase tag:?-?(MINT-1795496)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10844	uniprotkb:P29101	intact:EBI-7661991|uniprotkb:P10843|intact:MINT-1795550	intact:EBI-458017	psi-mi:bxb_clobo(display_long)|uniprotkb:botB(gene name)|psi-mi:botB(display_short)|uniprotkb:Bontoxilysin-B(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mahrhold et al. (2006)	pubmed:16545378|imex:IM-13944|mint:MINT-5218441	taxid:1491(clobo)|taxid:1491(Clostridium botulinum)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178984|mint:MINT-1795514|imex:IM-13944-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044156"(host cell junction)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044231"(host cell presynaptic membrane)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0090729"(toxin activity)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR012500(Clostridium neurotoxin, translocation)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036248|rcsb pdb:1EPW|rcsb pdb:1F31|rcsb pdb:1F82|rcsb pdb:1G9A|rcsb pdb:1G9B|rcsb pdb:1G9C|rcsb pdb:1G9D|rcsb pdb:1I1E|rcsb pdb:1S0B|rcsb pdb:1S0C|rcsb pdb:1S0D|rcsb pdb:1S0E|rcsb pdb:1S0F|rcsb pdb:1S0G|rcsb pdb:1Z0H|rcsb pdb:2ETF|rcsb pdb:2NM1|rcsb pdb:2NP0|rcsb pdb:2XHL|rcsb pdb:3ZUQ|rcsb pdb:4KBB|rcsb pdb:5VID|rcsb pdb:5VMR|rcsb pdb:6G5F|rcsb pdb:6G5G|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6UC6|rcsb pdb:6UFT|rcsb pdb:6UHT|rcsb pdb:6UL4|refseq:WP_012291519.1|reactome:R-HSA-5250958|dip:DIP-42782N|mint:MINT-1795515(identity)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101|mint:MINT-1795524(identity)	-	comment:mint|function:"Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2014/10/16	rogid:TyP1/JJzdgNBsIqolX4P5Vc+9Ag1491	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:04126B90F8412FE0|rigid:5VTvp7jz8LSWDObE8OcmI6JyJJQ	false	tag:?-?(MINT-1795522)|binding-associated region:441-1290(MINT-1795516)	glutathione s tranferase tag:?-?(MINT-1795531)|binding-associated region:1-90(MINT-1795525)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)