#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04917	uniprotkb:O60565	intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym)	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Namkoong et al. (2006)	pubmed:16545136|imex:IM-19869|mint:MINT-8007384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-914499|imex:IM-19869-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/31	2014/10/16	rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	intact-crc:2773C6A1E3B11C38|rigid:TMSzLR8yT2jPKUGI6XdvwX/XtUs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q04917	uniprotkb:O60565	intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym)	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Namkoong et al. (2006)	pubmed:16545136|imex:IM-19869|mint:MINT-8007384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-914576|imex:IM-19869-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/31	2014/10/16	rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	intact-crc:AD0E84880AD74A22|rigid:TMSzLR8yT2jPKUGI6XdvwX/XtUs	false	-	sufficient binding region:1-67|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04917	uniprotkb:O60565	intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym)	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Namkoong et al. (2006)	pubmed:16545136|imex:IM-19869|mint:MINT-8007384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-914594|imex:IM-19869-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/31	2014/10/16	rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	intact-crc:0DC93DCE9DF580DC|rigid:TMSzLR8yT2jPKUGI6XdvwX/XtUs	false	glutathione s tranferase tag:?-?|sufficient binding region:62-81	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04917	uniprotkb:O60565	intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym)	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Namkoong et al. (2006)	pubmed:16545136|imex:IM-19869|mint:MINT-8007384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-914607|imex:IM-19869-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/03/31	2014/10/16	rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	intact-crc:B0376DB7619EC63B|rigid:TMSzLR8yT2jPKUGI6XdvwX/XtUs	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04917	uniprotkb:O60565	intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym)	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Namkoong et al. (2006)	pubmed:16545136|imex:IM-19869|mint:MINT-8007384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-914614|imex:IM-19869-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/03/31	2014/10/16	rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	intact-crc:63FAF29E746E6EBB|rigid:TMSzLR8yT2jPKUGI6XdvwX/XtUs	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)