#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17712	uniprotkb:Q07071	intact:EBI-8178106|intact:MINT-1795103|uniprotkb:P17711	intact:EBI-710296|ensembl:ENSRNOP00000064260	psi-mi:hxk4_rat(display_long)|uniprotkb:Gck(gene name)|psi-mi:Gck(display_short)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:gckr_rat(display_long)|uniprotkb:Gckr(gene name)|psi-mi:Gckr(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Arden et al. (2006)	pubmed:16542652|imex:IM-10800|mint:MINT-5218438	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178091|mint:MINT-1795145|imex:IM-10800-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032811"(negative regulation of epinephrine secretion)|reactome:R-RNO-170822|reactome:R-RNO-70171|rgd:2670|interpro:IPR022672|refseq:NP_036697.1|interpro:IPR022673|refseq:NP_001257779.1|interpro:IPR019807|refseq:XP_006251241.1|interpro:IPR039073|interpro:IPR001312(Hexokinase)|interpro:IPR043129|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008865"(fructokinase activity)|go:"GO:0009749"(response to glucose)|go:"GO:0019158"(mannokinase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030141"(secretory granule)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043531"(ADP binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045180"(basal cortex)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070509"(calcium ion import)|mint:MINT-1795147(identity)	ensembl:ENSRNOG00000048874(gene)|ensembl:ENSRNOT00000073228(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0009750"(response to fructose)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046415"(urate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901135"(carbohydrate derivative metabolic process)|go:"GO:1903300"(negative regulation of hexokinase activity)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR005486(Glucokinase regulatory, conserved site)|interpro:IPR040190|rcsb pdb:4LC9|reactome:R-RNO-170822|rgd:2671|refseq:NP_037252.1|mint:MINT-1795146(identity)	-	comment:mint|function:Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hepatocyte)|taxid:10116(Rattus norvegicus hepatocytes)	-	2006/04/03	2014/10/16	rogid:vl2IpnPlpOMW2FyK0oOhg14oBiI10116	rogid:Gvc8qzcUWXyZoTCp2EC3LrnPnc810116	intact-crc:B57F6187BC095499|rigid:P6jLbLfbu7ifmYX2PLrSDMm3PtQ	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P10860	uniprotkb:Q07071	intact:EBI-349589|uniprotkb:Q66HI8|ensembl:ENSRNOP00000075032|uniprotkb:Q6LC16	intact:EBI-710296|ensembl:ENSRNOP00000064260	psi-mi:dhe3_rat(display_long)|uniprotkb:Glud1(gene name)|psi-mi:Glud1(display_short)|uniprotkb:Glud(gene name synonym)|uniprotkb:Memory-related gene 2 protein(gene name synonym)	psi-mi:gckr_rat(display_long)|uniprotkb:Gckr(gene name)|psi-mi:Gckr(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Arden et al. (2006)	pubmed:16542652|imex:IM-10800|mint:MINT-5218438	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178178|mint:MINT-2793478|imex:IM-10800-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2708|refseq:NP_036702.1|ensembl:ENSRNOG00000057367(gene)|ensembl:ENSRNOT00000083446(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0007616"(long-term memory)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043531"(ADP binding)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070728"(leucine binding)|go:"GO:0072350"(tricarboxylic acid metabolic process)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|reactome:R-RNO-2151201|reactome:R-RNO-8964539|mint:MINT-2793479(identity)	ensembl:ENSRNOG00000048874(gene)|ensembl:ENSRNOT00000073228(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0009750"(response to fructose)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046415"(urate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901135"(carbohydrate derivative metabolic process)|go:"GO:1903300"(negative regulation of hexokinase activity)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR005486(Glucokinase regulatory, conserved site)|interpro:IPR040190|rcsb pdb:4LC9|reactome:R-RNO-170822|rgd:2671|refseq:NP_037252.1|mint:MINT-2793485(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hepatocyte)|taxid:10116(Rattus norvegicus hepatocytes)	-	2006/04/03	2014/10/16	rogid:zlcsF8gp3Su+wZh9hFLGE5G3Fvk10116	rogid:Gvc8qzcUWXyZoTCp2EC3LrnPnc810116	intact-crc:E99A0DEDDA6CE978|rigid:tbcALocoaYdt1/Wf5wDVyqUIMeg	false	-	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P17712	uniprotkb:P10860	intact:EBI-8178106|intact:MINT-1795103|uniprotkb:P17711	intact:EBI-349589|uniprotkb:Q66HI8|ensembl:ENSRNOP00000075032|uniprotkb:Q6LC16	psi-mi:hxk4_rat(display_long)|uniprotkb:Gck(gene name)|psi-mi:Gck(display_short)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:dhe3_rat(display_long)|uniprotkb:Glud1(gene name)|psi-mi:Glud1(display_short)|uniprotkb:Glud(gene name synonym)|uniprotkb:Memory-related gene 2 protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Arden et al. (2006)	pubmed:16542652|imex:IM-10800|mint:MINT-5218438	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178191|mint:MINT-2793493|imex:IM-10800-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032811"(negative regulation of epinephrine secretion)|reactome:R-RNO-170822|reactome:R-RNO-70171|rgd:2670|interpro:IPR022672|refseq:NP_036697.1|interpro:IPR022673|refseq:NP_001257779.1|interpro:IPR019807|refseq:XP_006251241.1|interpro:IPR039073|interpro:IPR001312(Hexokinase)|interpro:IPR043129|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008865"(fructokinase activity)|go:"GO:0009749"(response to glucose)|go:"GO:0019158"(mannokinase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030141"(secretory granule)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043531"(ADP binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045180"(basal cortex)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070509"(calcium ion import)|mint:MINT-2793500(identity)	rgd:2708|refseq:NP_036702.1|ensembl:ENSRNOG00000057367(gene)|ensembl:ENSRNOT00000083446(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0007616"(long-term memory)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043531"(ADP binding)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070728"(leucine binding)|go:"GO:0072350"(tricarboxylic acid metabolic process)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|reactome:R-RNO-2151201|reactome:R-RNO-8964539|mint:MINT-2793494(identity)	-	comment:mint|function:Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hepatocyte)|taxid:10116(Rattus norvegicus hepatocytes)	-	2006/04/03	2014/10/16	rogid:vl2IpnPlpOMW2FyK0oOhg14oBiI10116	rogid:zlcsF8gp3Su+wZh9hFLGE5G3Fvk10116	intact-crc:D313E00C7A024EE5|rigid:8bnf5X3wfn0rp2w3Ua9p3eHMucA	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)