#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:V6CLJ5 uniprotkb:Q09260 intact:EBI-324482|ensemblmetazoa:K08B4.1d.1|uniprotkb:G5EDU7|uniprotkb:Q8MXE7|uniprotkb:V6CK60 intact:EBI-317579|uniprotkb:Q9NGS2|ensemblmetazoa:C32A3.1a.1 psi-mi:lag1_caeel(display_long)|uniprotkb:lag-1(gene name)|psi-mi:lag-1(display_short)|uniprotkb:CSL transcription factor lag-1(gene name synonym)|uniprotkb:Lin-12 and glp-1 phenotype protein(gene name synonym)|uniprotkb:K08B4.1(orf name) psi-mi:lag3_caeel(display_long)|uniprotkb:C32A3.1(orf name)|uniprotkb:Abnormal germline proliferation protein 3(gene name synonym)|uniprotkb:Abnormal cell lineage protein 3(gene name synonym)|uniprotkb:sel-8(gene name)|psi-mi:sel-8(display_short)|uniprotkb:lag-3(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Wilson et al. (2006) imex:IM-11965|pubmed:16530045 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-905391|wwpdb:2FO1|imex:IM-11965-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:K08B4.1a|uniprotkb:Q9TYY1(uniprot-removed-ac)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|rcsb pdb:1TTU|rcsb pdb:2FO1|interpro:IPR040159|ensemblmetazoa:K08B4.1d.1(transcript)|ensemblmetazoa:WBGene00002245(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0002119"(nematode larval development)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0018991"(oviposition)|go:"GO:0005112"(Notch binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0043054"(dauer exit)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR036358|interpro:IPR037095|refseq:NP_001023278.1|refseq:NP_001293739.1|refseq:NP_741410.1|rcsb pdb:3BRD|refseq:NP_001293740.1|wormbase:K08B4.1b|wormbase:K08B4.1c|wormbase:K08B4.1d refseq:NP_001021194.1|refseq:NP_001021195.1|wormbase:C32A3.1a|wormbase:C32A3.1b|interpro:IPR021587|rcsb pdb:2FO1|ensemblmetazoa:C32A3.1a.1(transcript)|ensemblmetazoa:WBGene00004765(gene)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000648"(positive regulation of stem cell proliferation) - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/15 2021/04/12 rogid:YTMXteMDHOJ71pq5S7FgjBOU6Fg6239 rogid:NiF1UnxTHsH8Pu9g+EtzBn4+C646239 intact-crc:CE7F30DF68302FD1|rigid:xMcIPRN5tLjWrMyXxW1KpRw5A2k false sufficient binding region:309-780 sufficient binding region:49-132 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:V6CLJ5 uniprotkb:P14585 intact:EBI-324482|ensemblmetazoa:K08B4.1d.1|uniprotkb:G5EDU7|uniprotkb:Q8MXE7|uniprotkb:V6CK60 intact:EBI-326049|ensemblmetazoa:R107.8.1 psi-mi:lag1_caeel(display_long)|uniprotkb:lag-1(gene name)|psi-mi:lag-1(display_short)|uniprotkb:CSL transcription factor lag-1(gene name synonym)|uniprotkb:Lin-12 and glp-1 phenotype protein(gene name synonym)|uniprotkb:K08B4.1(orf name) psi-mi:lin12_caeel(display_long)|uniprotkb:lin-12(gene name)|psi-mi:lin-12(display_short)|uniprotkb:Abnormal cell lineage protein 12(gene name synonym)|uniprotkb:Notch-like protein lin-12(gene name synonym)|uniprotkb:R107.8(orf name) psi-mi:"MI:0114"(x-ray crystallography) Wilson et al. (2006) imex:IM-11965|pubmed:16530045 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-905391|wwpdb:2FO1|imex:IM-11965-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:K08B4.1a|uniprotkb:Q9TYY1(uniprot-removed-ac)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|rcsb pdb:1TTU|rcsb pdb:2FO1|interpro:IPR040159|ensemblmetazoa:K08B4.1d.1(transcript)|ensemblmetazoa:WBGene00002245(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0002119"(nematode larval development)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0018991"(oviposition)|go:"GO:0005112"(Notch binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0043054"(dauer exit)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR036358|interpro:IPR037095|refseq:NP_001023278.1|refseq:NP_001293739.1|refseq:NP_741410.1|rcsb pdb:3BRD|refseq:NP_001293740.1|wormbase:K08B4.1b|wormbase:K08B4.1c|wormbase:K08B4.1d refseq:NP_499007.1|wormbase:R107.8|ensemblmetazoa:R107.8.1(transcript)|ensemblmetazoa:WBGene00003001(gene)|go:"GO:0001708"(cell fate specification)|go:"GO:0002119"(nematode larval development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018991"(oviposition)|go:"GO:0040025"(vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043054"(dauer exit)|go:"GO:0045168"(cell-cell signaling involved in cell fate commitment)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|dip:DIP-25208N|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR035993|interpro:IPR036770|rcsb pdb:2FO1|rcsb pdb:3BRD|rcsb pdb:3BRF - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/15 2021/04/12 rogid:YTMXteMDHOJ71pq5S7FgjBOU6Fg6239 rogid:s+lJ4eptcr8dmCYg+ZxLxPCPX1c6239 intact-crc:CE7F30DF68302FD1|rigid:xMcIPRN5tLjWrMyXxW1KpRw5A2k false sufficient binding region:309-780 sufficient binding region:931-1301 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)