#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37173	uniprotkb:Q99K41	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-906561|ensembl:ENSMUSP00000031055	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:emil1_mouse(display_long)|uniprotkb:Emilin1(gene name)|psi-mi:Emilin1(display_short)|uniprotkb:Elastin microfibril interface-located protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zacchigna et al. (2006)	pubmed:16530041|imex:IM-11825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-902913|imex:IM-11825-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_598679.1|ensembl:ENSMUSG00000029163(gene)|ensembl:ENSMUST00000031055(transcript)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098640"(integrin binding involved in cell-matrix adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1904027"(negative regulation of collagen fibril organization)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:1990971"(EMILIN complex)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|mint:Q99K41|reactome:R-MMU-2129379	imex:IM-317(imex secondary)	-	-	comment:The binding of 125I-TGF-beta was competed by cold TGF-beta1.|comment:GPI-anchored version of EMI-domain used for the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/13	2018/10/11	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:aebUu/5vuCmUIETy6uQJpa/QE8410090	intact-crc:D33E397FE5773270|rigid:zo/Hx3+FJuXD3aKkHLfUsP7V8Hk	false	ha tag:?-?	glycosylphosphatidylinositolated residue:n-n|sufficient binding region:28-213(IPR011489)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37173	uniprotkb:P07200	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-907660|uniprotkb:P08832|uniprotkb:K7GQZ2|ensembl:ENSSSCP00000030317|ensembl:ENSSSCP00015046877|ensembl:ENSSSCP00025011191|ensembl:ENSSSCP00030013147|ensembl:ENSSSCP00035020698|ensembl:ENSSSCP00040041585|ensembl:ENSSSCP00045038824|ensembl:ENSSSCP00050013072|ensembl:ENSSSCP00055013996|ensembl:ENSSSCP00060041409|ensembl:ENSSSCP00065006672|ensembl:ENSSSCP00070002984	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:tgfb1_pig(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zacchigna et al. (2006)	pubmed:16530041|imex:IM-11825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-902913|imex:IM-11825-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_999180.2|dip:DIP-35732N|ensembl:ENSSSCG00000003017(gene)|ensembl:ENSSSCG00015080792(gene)|ensembl:ENSSSCG00025019487(gene)|ensembl:ENSSSCG00030021126(gene)|ensembl:ENSSSCG00035038894(gene)|ensembl:ENSSSCG00040068791(gene)|ensembl:ENSSSCG00045032593(gene)|ensembl:ENSSSCG00050023190(gene)|ensembl:ENSSSCG00055009042(gene)|ensembl:ENSSSCG00060070125(gene)|ensembl:ENSSSCG00065012270(gene)|ensembl:ENSSSCG00070001924(gene)|ensembl:ENSSSCT00000036469(transcript)|ensembl:ENSSSCT00015109974(transcript)|ensembl:ENSSSCT00025026430(transcript)|ensembl:ENSSSCT00030029290(transcript)|ensembl:ENSSSCT00035051620(transcript)|ensembl:ENSSSCT00040094188(transcript)|ensembl:ENSSSCT00045055664(transcript)|ensembl:ENSSSCT00050031315(transcript)|ensembl:ENSSSCT00055017714(transcript)|ensembl:ENSSSCT00060095738(transcript)|ensembl:ENSSSCT00065016364(transcript)|ensembl:ENSSSCT00070003600(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060435"(bronchiole development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3RJR|rcsb pdb:5VQF|rcsb pdb:6UJA	imex:IM-317(imex secondary)	-	-	comment:The binding of 125I-TGF-beta was competed by cold TGF-beta1.|comment:GPI-anchored version of EMI-domain used for the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/13	2018/10/11	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:h8grS1I3YQEm3L1+AtX3Z2FcXoc9823	intact-crc:D33E397FE5773270|rigid:zo/Hx3+FJuXD3aKkHLfUsP7V8Hk	false	ha tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37173	uniprotkb:P07200	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-907660|uniprotkb:P08832|uniprotkb:K7GQZ2|ensembl:ENSSSCP00000030317|ensembl:ENSSSCP00015046877|ensembl:ENSSSCP00025011191|ensembl:ENSSSCP00030013147|ensembl:ENSSSCP00035020698|ensembl:ENSSSCP00040041585|ensembl:ENSSSCP00045038824|ensembl:ENSSSCP00050013072|ensembl:ENSSSCP00055013996|ensembl:ENSSSCP00060041409|ensembl:ENSSSCP00065006672|ensembl:ENSSSCP00070002984	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:tgfb1_pig(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zacchigna et al. (2006)	pubmed:16530041|imex:IM-11825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-902937|imex:IM-11825-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_999180.2|dip:DIP-35732N|ensembl:ENSSSCG00000003017(gene)|ensembl:ENSSSCG00015080792(gene)|ensembl:ENSSSCG00025019487(gene)|ensembl:ENSSSCG00030021126(gene)|ensembl:ENSSSCG00035038894(gene)|ensembl:ENSSSCG00040068791(gene)|ensembl:ENSSSCG00045032593(gene)|ensembl:ENSSSCG00050023190(gene)|ensembl:ENSSSCG00055009042(gene)|ensembl:ENSSSCG00060070125(gene)|ensembl:ENSSSCG00065012270(gene)|ensembl:ENSSSCG00070001924(gene)|ensembl:ENSSSCT00000036469(transcript)|ensembl:ENSSSCT00015109974(transcript)|ensembl:ENSSSCT00025026430(transcript)|ensembl:ENSSSCT00030029290(transcript)|ensembl:ENSSSCT00035051620(transcript)|ensembl:ENSSSCT00040094188(transcript)|ensembl:ENSSSCT00045055664(transcript)|ensembl:ENSSSCT00050031315(transcript)|ensembl:ENSSSCT00055017714(transcript)|ensembl:ENSSSCT00060095738(transcript)|ensembl:ENSSSCT00065016364(transcript)|ensembl:ENSSSCT00070003600(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060435"(bronchiole development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3RJR|rcsb pdb:5VQF|rcsb pdb:6UJA	imex:IM-320(imex secondary)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/13	2018/10/11	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:h8grS1I3YQEm3L1+AtX3Z2FcXoc9823	intact-crc:AC693D511C313AF6|rigid:cnKZMdclLP/ugEGRqm65NIJeAc4	false	ha tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99K41	uniprotkb:P07200	intact:EBI-906561|ensembl:ENSMUSP00000031055	intact:EBI-907660|uniprotkb:P08832|uniprotkb:K7GQZ2|ensembl:ENSSSCP00000030317|ensembl:ENSSSCP00015046877|ensembl:ENSSSCP00025011191|ensembl:ENSSSCP00030013147|ensembl:ENSSSCP00035020698|ensembl:ENSSSCP00040041585|ensembl:ENSSSCP00045038824|ensembl:ENSSSCP00050013072|ensembl:ENSSSCP00055013996|ensembl:ENSSSCP00060041409|ensembl:ENSSSCP00065006672|ensembl:ENSSSCP00070002984	psi-mi:emil1_mouse(display_long)|uniprotkb:Emilin1(gene name)|psi-mi:Emilin1(display_short)|uniprotkb:Elastin microfibril interface-located protein 1(gene name synonym)	psi-mi:tgfb1_pig(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zacchigna et al. (2006)	pubmed:16530041|imex:IM-11825	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-902996|imex:IM-11825-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598679.1|ensembl:ENSMUSG00000029163(gene)|ensembl:ENSMUST00000031055(transcript)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098640"(integrin binding involved in cell-matrix adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1904027"(negative regulation of collagen fibril organization)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:1990971"(EMILIN complex)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|mint:Q99K41|reactome:R-MMU-2129379	refseq:NP_999180.2|dip:DIP-35732N|ensembl:ENSSSCG00000003017(gene)|ensembl:ENSSSCG00015080792(gene)|ensembl:ENSSSCG00025019487(gene)|ensembl:ENSSSCG00030021126(gene)|ensembl:ENSSSCG00035038894(gene)|ensembl:ENSSSCG00040068791(gene)|ensembl:ENSSSCG00045032593(gene)|ensembl:ENSSSCG00050023190(gene)|ensembl:ENSSSCG00055009042(gene)|ensembl:ENSSSCG00060070125(gene)|ensembl:ENSSSCG00065012270(gene)|ensembl:ENSSSCG00070001924(gene)|ensembl:ENSSSCT00000036469(transcript)|ensembl:ENSSSCT00015109974(transcript)|ensembl:ENSSSCT00025026430(transcript)|ensembl:ENSSSCT00030029290(transcript)|ensembl:ENSSSCT00035051620(transcript)|ensembl:ENSSSCT00040094188(transcript)|ensembl:ENSSSCT00045055664(transcript)|ensembl:ENSSSCT00050031315(transcript)|ensembl:ENSSSCT00055017714(transcript)|ensembl:ENSSSCT00060095738(transcript)|ensembl:ENSSSCT00065016364(transcript)|ensembl:ENSSSCT00070003600(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060435"(bronchiole development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3RJR|rcsb pdb:5VQF|rcsb pdb:6UJA	imex:IM-319(imex secondary)	-	-	sample process:P07200; Q99K41 transfected|antibodies:Anti-LAP antibodies used for CoIP. Precursor is cleaved to give LAP and TGF-beta1 proteins.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/03/13	2018/10/11	rogid:aebUu/5vuCmUIETy6uQJpa/QE8410090	rogid:h8grS1I3YQEm3L1+AtX3Z2FcXoc9823	intact-crc:B5037A797E958D02|rigid:sYRJ3Pb6MuFZxmKl1ToMHsd5RDM	false	sufficient binding region:28-231(IPR011489)|flag tag:n-n|glycosylphosphatidylinositolated residue:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99K41	uniprotkb:P07200	intact:EBI-906561|ensembl:ENSMUSP00000031055	intact:EBI-907660|uniprotkb:P08832|uniprotkb:K7GQZ2|ensembl:ENSSSCP00000030317|ensembl:ENSSSCP00015046877|ensembl:ENSSSCP00025011191|ensembl:ENSSSCP00030013147|ensembl:ENSSSCP00035020698|ensembl:ENSSSCP00040041585|ensembl:ENSSSCP00045038824|ensembl:ENSSSCP00050013072|ensembl:ENSSSCP00055013996|ensembl:ENSSSCP00060041409|ensembl:ENSSSCP00065006672|ensembl:ENSSSCP00070002984	psi-mi:emil1_mouse(display_long)|uniprotkb:Emilin1(gene name)|psi-mi:Emilin1(display_short)|uniprotkb:Elastin microfibril interface-located protein 1(gene name synonym)	psi-mi:tgfb1_pig(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zacchigna et al. (2006)	pubmed:16530041|imex:IM-11825	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-902952|imex:IM-11825-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598679.1|ensembl:ENSMUSG00000029163(gene)|ensembl:ENSMUST00000031055(transcript)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098640"(integrin binding involved in cell-matrix adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1904027"(negative regulation of collagen fibril organization)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:1990971"(EMILIN complex)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|mint:Q99K41|reactome:R-MMU-2129379	refseq:NP_999180.2|dip:DIP-35732N|ensembl:ENSSSCG00000003017(gene)|ensembl:ENSSSCG00015080792(gene)|ensembl:ENSSSCG00025019487(gene)|ensembl:ENSSSCG00030021126(gene)|ensembl:ENSSSCG00035038894(gene)|ensembl:ENSSSCG00040068791(gene)|ensembl:ENSSSCG00045032593(gene)|ensembl:ENSSSCG00050023190(gene)|ensembl:ENSSSCG00055009042(gene)|ensembl:ENSSSCG00060070125(gene)|ensembl:ENSSSCG00065012270(gene)|ensembl:ENSSSCG00070001924(gene)|ensembl:ENSSSCT00000036469(transcript)|ensembl:ENSSSCT00015109974(transcript)|ensembl:ENSSSCT00025026430(transcript)|ensembl:ENSSSCT00030029290(transcript)|ensembl:ENSSSCT00035051620(transcript)|ensembl:ENSSSCT00040094188(transcript)|ensembl:ENSSSCT00045055664(transcript)|ensembl:ENSSSCT00050031315(transcript)|ensembl:ENSSSCT00055017714(transcript)|ensembl:ENSSSCT00060095738(transcript)|ensembl:ENSSSCT00065016364(transcript)|ensembl:ENSSSCT00070003600(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060435"(bronchiole development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3RJR|rcsb pdb:5VQF|rcsb pdb:6UJA	imex:IM-319(imex secondary)	-	-	sample process:P07200; Q99K41 transfected|comment:Monomer and dimers of proTGf-beta1 were detected.|antibodies:Anti-LAP antibodies used to detect bound TGF- beta 1 proteins. Precursor is cleaved to give LAP and tgf-beta1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/03/13	2018/10/11	rogid:aebUu/5vuCmUIETy6uQJpa/QE8410090	rogid:h8grS1I3YQEm3L1+AtX3Z2FcXoc9823	intact-crc:4E44CFC740F2E7B6|rigid:sYRJ3Pb6MuFZxmKl1ToMHsd5RDM	false	flag tag:n-n|glycosylphosphatidylinositolated residue:n-n|sufficient binding region:28-231(IPR011489)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6C2	uniprotkb:P07200	intact:EBI-744586|ensembl:ENSP00000369677|uniprotkb:A0A0C4DFX3|intact:EBI-902920|uniprotkb:A5PL03|uniprotkb:H0Y7A0|uniprotkb:Q53SY9|uniprotkb:Q96G58|uniprotkb:Q96IH6|uniprotkb:Q9UG76	intact:EBI-907660|uniprotkb:P08832|uniprotkb:K7GQZ2|ensembl:ENSSSCP00000030317|ensembl:ENSSSCP00015046877|ensembl:ENSSSCP00025011191|ensembl:ENSSSCP00030013147|ensembl:ENSSSCP00035020698|ensembl:ENSSSCP00040041585|ensembl:ENSSSCP00045038824|ensembl:ENSSSCP00050013072|ensembl:ENSSSCP00055013996|ensembl:ENSSSCP00060041409|ensembl:ENSSSCP00065006672|ensembl:ENSSSCP00070002984	psi-mi:emil1_human(display_long)|uniprotkb:EMILIN1(gene name)|psi-mi:EMILIN1(display_short)|uniprotkb:EMI(gene name synonym)|uniprotkb:Elastin microfibril interface-located protein 1(gene name synonym)	psi-mi:tgfb1_pig(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zacchigna et al. (2006)	pubmed:16530041|imex:IM-11825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-903057|imex:IM-11825-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|mint:Q9Y6C2|rcsb pdb:2KA3|rcsb pdb:2OII|reactome:R-HSA-2129379|ensembl:ENSG00000138080(gene)|ensembl:ENST00000380320(transcript)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098640"(integrin binding involved in cell-matrix adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1904027"(negative regulation of collagen fibril organization)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:1990971"(EMILIN complex)|refseq:NP_008977.1|dip:DIP-35733N	refseq:NP_999180.2|dip:DIP-35732N|ensembl:ENSSSCG00000003017(gene)|ensembl:ENSSSCG00015080792(gene)|ensembl:ENSSSCG00025019487(gene)|ensembl:ENSSSCG00030021126(gene)|ensembl:ENSSSCG00035038894(gene)|ensembl:ENSSSCG00040068791(gene)|ensembl:ENSSSCG00045032593(gene)|ensembl:ENSSSCG00050023190(gene)|ensembl:ENSSSCG00055009042(gene)|ensembl:ENSSSCG00060070125(gene)|ensembl:ENSSSCG00065012270(gene)|ensembl:ENSSSCG00070001924(gene)|ensembl:ENSSSCT00000036469(transcript)|ensembl:ENSSSCT00015109974(transcript)|ensembl:ENSSSCT00025026430(transcript)|ensembl:ENSSSCT00030029290(transcript)|ensembl:ENSSSCT00035051620(transcript)|ensembl:ENSSSCT00040094188(transcript)|ensembl:ENSSSCT00045055664(transcript)|ensembl:ENSSSCT00050031315(transcript)|ensembl:ENSSSCT00055017714(transcript)|ensembl:ENSSSCT00060095738(transcript)|ensembl:ENSSSCT00065016364(transcript)|ensembl:ENSSSCT00070003600(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060435"(bronchiole development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3RJR|rcsb pdb:5VQF|rcsb pdb:6UJA	imex:IM-318(imex secondary)	-	-	sample process:P07200 transfected|antibodies:anti-LAP antibodies used for CoIP.|expression level:P07200 overexpressed; Q9Y6C2 endogenous|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/03/13	2018/10/11	rogid:lJnDOaq3HA5TUGd1Skz/1s3DIxM9606	rogid:h8grS1I3YQEm3L1+AtX3Z2FcXoc9823	intact-crc:4A502A18377B8A4F|rigid:JBvvhDSsaYkn8cKwdgrtW3MmYcA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)