#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60680	uniprotkb:O88351	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Vacca et al. (2006)	pubmed:16498412|imex:IM-13930|mint:MINT-5218365	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8094903|mint:MINT-1955836|imex:IM-13930-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)|mint:MINT-1955837(identity)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|mint:MINT-1955838(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2006/05/24	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:C32703DFEDBDCA93|rigid:PcnRPJhJfe4+D1bs5ZBYLvkL1oo	false	-	-	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61982	uniprotkb:Q99558	intact:EBI-8094917|intact:MINT-1955915|ensembl:ENSMUSP00000085016	intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657	psi-mi:notc3_mouse(display_long)|uniprotkb:Notch3(gene name)|psi-mi:Notch3(display_short)	psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Vacca et al. (2006)	pubmed:16498412|imex:IM-13930|mint:MINT-5218365	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8094954|mint:MINT-1955898|imex:IM-13930-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032742.1|ensembl:ENSMUSG00000038146(gene)|ensembl:ENSMUST00000087723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030900"(forebrain development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0072104"(glomerular capillary formation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022331|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q61982|reactome:R-MMU-1912420|reactome:R-MMU-350054|reactome:R-MMU-9013507|reactome:R-MMU-9017802|mint:MINT-1955904(identity)	refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594|mint:MINT-1955899(identity)	-	comment:mint|function:"Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2006/05/24	2014/10/16	rogid:9pvkvUX4uDKDpVLNUwKKj4qPNJs10090	rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606	intact-crc:622C1EC2CDC5DCF0|rigid:cnymd/D3+vkDnvypXR+0nl3hlRI	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15111	uniprotkb:Q99558	intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970	intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657	psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym)	psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Vacca et al. (2006)	pubmed:16498412|imex:IM-13930|mint:MINT-5218365	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095003|mint:MINT-1955970|imex:IM-13930-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N|mint:MINT-1955971(identity)	refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594|mint:MINT-1955977(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2006/05/24	2014/10/16	rogid:FVB/gXjSBTB9hdq9pycQogxesms9606	rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606	intact-crc:C1B3F7C2937BB175|rigid:3Dy0tdp7ZJfhIP/jYvzN7PrcDeo	false	-	-	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61982	uniprotkb:O15111	intact:EBI-8094917|intact:MINT-1955915|ensembl:ENSMUSP00000085016	intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970	psi-mi:notc3_mouse(display_long)|uniprotkb:Notch3(gene name)|psi-mi:Notch3(display_short)	psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Vacca et al. (2006)	pubmed:16498412|imex:IM-13930|mint:MINT-5218365	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8094968|mint:MINT-1955949|imex:IM-13930-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032742.1|ensembl:ENSMUSG00000038146(gene)|ensembl:ENSMUST00000087723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030900"(forebrain development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0072104"(glomerular capillary formation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022331|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q61982|reactome:R-MMU-1912420|reactome:R-MMU-350054|reactome:R-MMU-9013507|reactome:R-MMU-9017802|mint:MINT-1955956(identity)	refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N|mint:MINT-1955950(identity)	-	comment:mint|function:"Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2006/05/24	2014/10/16	rogid:9pvkvUX4uDKDpVLNUwKKj4qPNJs10090	rogid:FVB/gXjSBTB9hdq9pycQogxesms9606	intact-crc:2EAF8994EBC319FE|rigid:HcNtgpPne65eSMQDx5S9j262OK4	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)