#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08476	uniprotkb:P21674	intact:EBI-8077140|intact:MINT-1786936|uniprotkb:Q14599|ensembl:ENSP00000242208|ensembl:ENSP00000397197|ensembl:ENSP00000490646	intact:EBI-5746973|uniprotkb:Q80XW7|ensembl:ENSRNOP00000015680	psi-mi:inhba_human(display_long)|uniprotkb:INHBA(gene name)|psi-mi:INHBA(display_short)|uniprotkb:Activin beta-A chain(gene name synonym)|uniprotkb:Erythroid differentiation protein(gene name synonym)	psi-mi:fst_rat(display_long)|uniprotkb:Fst(gene name)|psi-mi:Fst(display_short)|uniprotkb:Activin-binding protein(gene name synonym)	psi-mi:"MI:0091"(chromatography technology)	Harrington et al. (2006)	pubmed:16482217|imex:IM-10971|mint:MINT-5218335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8077132|mint:MINT-1787021|imex:IM-10971-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002183.1|refseq:XP_016867665.1|dip:DIP-5824N|go:"GO:0001942"(hair follicle development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0034711"(inhibin binding)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043509"(activin A complex)|go:"GO:0043512"(inhibin A complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|ensembl:ENSG00000122641(gene)|ensembl:ENST00000242208(transcript)|ensembl:ENST00000442711(transcript)|ensembl:ENST00000638023(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046880"(regulation of follicle-stimulating hormone secretion)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0046882"(negative regulation of follicle-stimulating hormone secretion)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060279"(positive regulation of ovulation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0097154"(GABAergic neuron differentiation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0045786"(negative regulation of cell cycle)|rcsb pdb:2B0U|rcsb pdb:2P6A|rcsb pdb:3B4V|rcsb pdb:4MID|rcsb pdb:5HLY|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000491(Inhibin, beta A subunit, N-terminal)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1NYS|rcsb pdb:1NYU|rcsb pdb:1S4Y|rcsb pdb:2ARP|rcsb pdb:2ARV|rcsb pdb:5HLZ|rcsb pdb:6Y6O|reactome:R-HSA-1502540|reactome:R-HSA-209822|reactome:R-HSA-2473224|rcsb pdb:6Y6N|mint:MINT-1787022(identity)	rgd:2633|refseq:NP_036693.1|ensembl:ENSRNOG00000011631(gene)|ensembl:ENSRNOT00000015680(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0007389"(pattern specification process)|go:"GO:0008585"(female gonad development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0038102"(activin receptor antagonist activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046882"(negative regulation of follicle-stimulating hormone secretion)|go:"GO:0048185"(activin binding)|go:"GO:0051798"(positive regulation of hair follicle development)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR017878|interpro:IPR036058|interpro:IPR036773|rcsb pdb:1LR7|rcsb pdb:1LR8|rcsb pdb:1LR9|rcsb pdb:2ARP|reactome:R-RNO-2473224|mint:MINT-1787023(identity)	-	function:Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:E9GSsHGx76YbLyph+qI5Hx8nos09606	rogid:gxXggD5o3Asz0l8DhQVUxIqusnA10116	intact-crc:7BA12A7E6E82CA57|rigid:cq9appRaraaCLxtSe2S+qHjDMcI	false	mutation decreasing interaction:221-221(MINT-1787093)|binding-associated region:93-241(MINT-1787091)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08476	uniprotkb:P21674	intact:EBI-8077140|intact:MINT-1786936|uniprotkb:Q14599|ensembl:ENSP00000242208|ensembl:ENSP00000397197|ensembl:ENSP00000490646	intact:EBI-5746973|uniprotkb:Q80XW7|ensembl:ENSRNOP00000015680	psi-mi:inhba_human(display_long)|uniprotkb:INHBA(gene name)|psi-mi:INHBA(display_short)|uniprotkb:Activin beta-A chain(gene name synonym)|uniprotkb:Erythroid differentiation protein(gene name synonym)	psi-mi:fst_rat(display_long)|uniprotkb:Fst(gene name)|psi-mi:Fst(display_short)|uniprotkb:Activin-binding protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Harrington et al. (2006)	pubmed:16482217|imex:IM-10971|mint:MINT-5218335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8077249|mint:MINT-1787165|imex:IM-10971-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002183.1|refseq:XP_016867665.1|dip:DIP-5824N|go:"GO:0001942"(hair follicle development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0034711"(inhibin binding)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043509"(activin A complex)|go:"GO:0043512"(inhibin A complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|ensembl:ENSG00000122641(gene)|ensembl:ENST00000242208(transcript)|ensembl:ENST00000442711(transcript)|ensembl:ENST00000638023(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046880"(regulation of follicle-stimulating hormone secretion)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0046882"(negative regulation of follicle-stimulating hormone secretion)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060279"(positive regulation of ovulation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0097154"(GABAergic neuron differentiation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0045786"(negative regulation of cell cycle)|rcsb pdb:2B0U|rcsb pdb:2P6A|rcsb pdb:3B4V|rcsb pdb:4MID|rcsb pdb:5HLY|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000491(Inhibin, beta A subunit, N-terminal)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1NYS|rcsb pdb:1NYU|rcsb pdb:1S4Y|rcsb pdb:2ARP|rcsb pdb:2ARV|rcsb pdb:5HLZ|rcsb pdb:6Y6O|reactome:R-HSA-1502540|reactome:R-HSA-209822|reactome:R-HSA-2473224|rcsb pdb:6Y6N|mint:MINT-1787166(identity)	rgd:2633|refseq:NP_036693.1|ensembl:ENSRNOG00000011631(gene)|ensembl:ENSRNOT00000015680(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0007389"(pattern specification process)|go:"GO:0008585"(female gonad development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0038102"(activin receptor antagonist activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046882"(negative regulation of follicle-stimulating hormone secretion)|go:"GO:0048185"(activin binding)|go:"GO:0051798"(positive regulation of hair follicle development)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR017878|interpro:IPR036058|interpro:IPR036773|rcsb pdb:1LR7|rcsb pdb:1LR8|rcsb pdb:1LR9|rcsb pdb:2ARP|reactome:R-RNO-2473224|mint:MINT-1787173(identity)	-	function:Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2E|kinetics:kd 430 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:E9GSsHGx76YbLyph+qI5Hx8nos09606	rogid:gxXggD5o3Asz0l8DhQVUxIqusnA10116	intact-crc:54AD0B8A5E687EC0|rigid:cq9appRaraaCLxtSe2S+qHjDMcI	false	binding-associated region:93-241(MINT-1787167)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)