#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9ET38 uniprotkb:O97758 intact:EBI-8036280|intact:MINT-1771795|uniprotkb:Q8R4B7|ensembl:ENSMUSP00000081334 intact:EBI-6988333|intact:MINT-1778189 psi-mi:cld19_mouse(display_long)|uniprotkb:Cldn19(gene name)|psi-mi:Cldn19(display_short) psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lee et al. (2006) pubmed:16427635|imex:IM-11084|mint:MINT-5218266 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8036306|mint:MINT-1778177|imex:IM-11084-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001033679.1|refseq:NP_694745.1|dip:DIP-42881N|ensembl:ENSMUSG00000066058(gene)|ensembl:ENSMUST00000084309(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0120193"(tight junction organization)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1901890"(positive regulation of cell junction assembly)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|rcsb pdb:3X29|mint:MINT-1778183(identity) interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-1778206(identity) - comment:mint|function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity|comment:"Stoichiometry: 1.0" comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions|comment:"Stoichiometry: 1.0" figure legend:F3G|comment:Since for canine Claudin-19 is not annotated in Swiss-Prot we used the murine identifier|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells") - 2006/03/07 2014/10/16 rogid:NC33RbgWuPs00nETT2b/D4Fk3LI10090 rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615 intact-crc:16C837A7E274B688|rigid:lxJyIgE8m5DKZEyPLbiGolLCwVQ false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)