#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09167	uniprotkb:P32004	intact:EBI-8027669|intact:MINT-1958193	intact:EBI-720783|uniprotkb:B2RMU7|uniprotkb:A0AV65|uniprotkb:Q8TA87|uniprotkb:A4ZYW4|uniprotkb:G3XAF4|ensembl:ENSP00000359077	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:l1cam_human(display_long)|uniprotkb:L1CAM(gene name)|psi-mi:L1CAM(display_short)|uniprotkb:CAML1(gene name synonym)|uniprotkb:MIC5(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Iacovache et al. (2006)	pubmed:16424900|imex:IM-11001|mint:MINT-5218244	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8027692|mint:MINT-1958206|imex:IM-11001-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW|mint:MINT-1958208(identity)	refseq:NP_000416.1|refseq:NP_001137435.1|refseq:NP_076493.1|refseq:NP_001265045.1|ensembl:ENSG00000198910(gene)|ensembl:ENST00000370060(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050808"(synapse organization)|go:"GO:0061564"(axon development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026966|interpro:IPR036116|interpro:IPR036179|mint:P32004|reactome:R-HSA-210991|reactome:R-HSA-373760|reactome:R-HSA-437239|reactome:R-HSA-445095|reactome:R-HSA-445144|mint:MINT-1958207(identity)	-	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2A|comment:For N-CAm was used the human UP_ID|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/26	2014/10/16	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rogid:ytWIAO1KRRtvqhmtH+CZjN/Hrbs9606	intact-crc:E2B6CB42F8F28468|rigid:1K+JAqjkaKz3YBP41GI++e3ABXU	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09167	uniprotkb:O75326	intact:EBI-8027669|intact:MINT-1958193	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Iacovache et al. (2006)	pubmed:16424900|imex:IM-11001|mint:MINT-5218244	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8027723|mint:MINT-1958236|imex:IM-11001-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW|mint:MINT-1958237(identity)	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700|mint:MINT-1958242(identity)	-	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2A|comment:For semaphorin 7A was used the human UP_ID|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/26	2014/10/16	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	intact-crc:534DAA8C3E17AF1D|rigid:Q75HrMnHiFkRNOCM3WDC9zHZtzA	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09167	uniprotkb:P09167	intact:EBI-8027669|intact:MINT-1958193	intact:EBI-8027669|intact:MINT-1958193	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:"MI:0401"(biochemical)	Iacovache et al. (2006)	pubmed:16424900|imex:IM-11001|mint:MINT-5218244	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8027747|mint:MINT-1958272|imex:IM-11001-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW|mint:MINT-1958273(identity)	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW|mint:MINT-1958278(identity)	-	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis|comment:"Stoichiometry: 1.0"	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis|comment:"Stoichiometry: 1.0"	figure legend:F2B|figure legend:F2C|comment:the interaction brings to heptamerisation|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/26	2014/10/16	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	intact-crc:320445A61518BCC7|rigid:BapDOcDxnu69Vky4Q80J5c79Lrk	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)