#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NRM7 uniprotkb:Q96IF1 intact:EBI-3506895|uniprotkb:B1AM47|uniprotkb:Q9P2X1|ensembl:ENSP00000372035 intact:EBI-949782|intact:EBI-28987773|ensembl:ENSP00000262713|ensembl:ENSP00000354491|uniprotkb:D3DS37|uniprotkb:A8MX18 psi-mi:lats2_human(display_long)|uniprotkb:LATS2(gene name)|psi-mi:LATS2(display_short)|uniprotkb:KPM(gene name synonym)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)|uniprotkb:Warts-like kinase(gene name synonym) psi-mi:ajuba_human(display_long)|uniprotkb:AJUBA(gene name)|psi-mi:AJUBA(display_short)|uniprotkb:JUB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Abe et al. (2006) pubmed:16413547|imex:IM-9478|mint:MINT-5218235 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8019485|mint:MINT-1771993|imex:IM-9478-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055387.2|ensembl:ENSG00000150457(gene)|ensembl:ENST00000382592(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR028742|rcsb pdb:4ZRI|reactome:R-HSA-2028269|ensembl:ENSP00000372035|refseq:XP_005266399.1|dip:DIP-43883N|mint:MINT-1772029(identity) go:"GO:0045294"(alpha-catenin binding)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|go:"GO:0030027"(lamellipodium)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0034613"(cellular protein localization)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q96IF1|go:"GO:0035195"(gene silencing by miRNA)|reactome:R-HSA-1234176|reactome:R-HSA-2565942|reactome:R-HSA-5617472|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|ensembl:ENSG00000129474(gene)|ensembl:ENST00000262713(transcript)|ensembl:ENST00000361265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_116265.1|refseq:NP_932352.1|ensembl:ENSP00000262713|ensembl:ENSP00000354491|ensembl:ENST00000397388|ensembl:ENSP00000380543|refseq:NP_001276026.1|mint:MINT-1772047(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2006/03/07 2014/10/16 rogid:BG2iO0Zw2KutrLOqxz6pysnA2Xc9606 rogid:l3GAffQ5t7Cfb9iQLE/hdyNQwbw9606 intact-crc:5310DCEA235D5A89|rigid:yfPrHzSwrOnot6VCGeSKhArPsCI false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q96IF1 uniprotkb:Q9NRM7 intact:EBI-949782|intact:EBI-28987773|ensembl:ENSP00000262713|ensembl:ENSP00000354491|uniprotkb:D3DS37|uniprotkb:A8MX18 intact:EBI-3506895|uniprotkb:B1AM47|uniprotkb:Q9P2X1|ensembl:ENSP00000372035 psi-mi:ajuba_human(display_long)|uniprotkb:AJUBA(gene name)|psi-mi:AJUBA(display_short)|uniprotkb:JUB(gene name synonym) psi-mi:lats2_human(display_long)|uniprotkb:LATS2(gene name)|psi-mi:LATS2(display_short)|uniprotkb:KPM(gene name synonym)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)|uniprotkb:Warts-like kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Abe et al. (2006) pubmed:16413547|imex:IM-9478|mint:MINT-5218235 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8019545|mint:MINT-1772055|imex:IM-9478-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045294"(alpha-catenin binding)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|go:"GO:0030027"(lamellipodium)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0034613"(cellular protein localization)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q96IF1|go:"GO:0035195"(gene silencing by miRNA)|reactome:R-HSA-1234176|reactome:R-HSA-2565942|reactome:R-HSA-5617472|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|ensembl:ENSG00000129474(gene)|ensembl:ENST00000262713(transcript)|ensembl:ENST00000361265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_116265.1|refseq:NP_932352.1|ensembl:ENSP00000262713|ensembl:ENSP00000354491|ensembl:ENST00000397388|ensembl:ENSP00000380543|refseq:NP_001276026.1|mint:MINT-1772071(identity) refseq:NP_055387.2|ensembl:ENSG00000150457(gene)|ensembl:ENST00000382592(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR028742|rcsb pdb:4ZRI|reactome:R-HSA-2028269|ensembl:ENSP00000372035|refseq:XP_005266399.1|dip:DIP-43883N|mint:MINT-1772061(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/03/07 2014/10/16 rogid:l3GAffQ5t7Cfb9iQLE/hdyNQwbw9606 rogid:BG2iO0Zw2KutrLOqxz6pysnA2Xc9606 intact-crc:37A3A9A1F51555ED|rigid:yfPrHzSwrOnot6VCGeSKhArPsCI false - binding-associated region:629-1086(MINT-1772069)|flag tag:?-?(MINT-1772062) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9NRM7 uniprotkb:Q96IF1 intact:EBI-3506895|uniprotkb:B1AM47|uniprotkb:Q9P2X1|ensembl:ENSP00000372035 intact:EBI-949782|intact:EBI-28987773|ensembl:ENSP00000262713|ensembl:ENSP00000354491|uniprotkb:D3DS37|uniprotkb:A8MX18 psi-mi:lats2_human(display_long)|uniprotkb:LATS2(gene name)|psi-mi:LATS2(display_short)|uniprotkb:KPM(gene name synonym)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)|uniprotkb:Warts-like kinase(gene name synonym) psi-mi:ajuba_human(display_long)|uniprotkb:AJUBA(gene name)|psi-mi:AJUBA(display_short)|uniprotkb:JUB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Abe et al. (2006) pubmed:16413547|imex:IM-9478|mint:MINT-5218235 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8019566|mint:MINT-1790017|imex:IM-9478-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055387.2|ensembl:ENSG00000150457(gene)|ensembl:ENST00000382592(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR028742|rcsb pdb:4ZRI|reactome:R-HSA-2028269|ensembl:ENSP00000372035|refseq:XP_005266399.1|dip:DIP-43883N|mint:MINT-1790019(identity) go:"GO:0045294"(alpha-catenin binding)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|go:"GO:0030027"(lamellipodium)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0034613"(cellular protein localization)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q96IF1|go:"GO:0035195"(gene silencing by miRNA)|reactome:R-HSA-1234176|reactome:R-HSA-2565942|reactome:R-HSA-5617472|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|ensembl:ENSG00000129474(gene)|ensembl:ENST00000262713(transcript)|ensembl:ENST00000361265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_116265.1|refseq:NP_932352.1|ensembl:ENSP00000262713|ensembl:ENSP00000354491|ensembl:ENST00000397388|ensembl:ENSP00000380543|refseq:NP_001276026.1|mint:MINT-1790029(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/03/07 2014/10/16 rogid:BG2iO0Zw2KutrLOqxz6pysnA2Xc9606 rogid:l3GAffQ5t7Cfb9iQLE/hdyNQwbw9606 intact-crc:DA0F4815B4A43E2D|rigid:yfPrHzSwrOnot6VCGeSKhArPsCI false binding-associated region:1-392(MINT-1790020)|flag tag:?-?(MINT-1790027) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9NRM7 uniprotkb:Q96IF1 intact:EBI-3506895|uniprotkb:B1AM47|uniprotkb:Q9P2X1|ensembl:ENSP00000372035 intact:EBI-949782|intact:EBI-28987773|ensembl:ENSP00000262713|ensembl:ENSP00000354491|uniprotkb:D3DS37|uniprotkb:A8MX18 psi-mi:lats2_human(display_long)|uniprotkb:LATS2(gene name)|psi-mi:LATS2(display_short)|uniprotkb:KPM(gene name synonym)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)|uniprotkb:Warts-like kinase(gene name synonym) psi-mi:ajuba_human(display_long)|uniprotkb:AJUBA(gene name)|psi-mi:AJUBA(display_short)|uniprotkb:JUB(gene name synonym) psi-mi:"MI:0096"(pull down) Abe et al. (2006) pubmed:16413547|imex:IM-9478|mint:MINT-5218235 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8019609|mint:MINT-1772097|imex:IM-9478-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055387.2|ensembl:ENSG00000150457(gene)|ensembl:ENST00000382592(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR028742|rcsb pdb:4ZRI|reactome:R-HSA-2028269|ensembl:ENSP00000372035|refseq:XP_005266399.1|dip:DIP-43883N|mint:MINT-1772118(identity) go:"GO:0045294"(alpha-catenin binding)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|go:"GO:0030027"(lamellipodium)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0034613"(cellular protein localization)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q96IF1|go:"GO:0035195"(gene silencing by miRNA)|reactome:R-HSA-1234176|reactome:R-HSA-2565942|reactome:R-HSA-5617472|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|ensembl:ENSG00000129474(gene)|ensembl:ENST00000262713(transcript)|ensembl:ENST00000361265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_116265.1|refseq:NP_932352.1|ensembl:ENSP00000262713|ensembl:ENSP00000354491|ensembl:ENST00000397388|ensembl:ENSP00000380543|refseq:NP_001276026.1|mint:MINT-1772107(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1F|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/03/07 2014/10/16 rogid:BG2iO0Zw2KutrLOqxz6pysnA2Xc9606 rogid:l3GAffQ5t7Cfb9iQLE/hdyNQwbw9606 intact-crc:56C7771D1506BA1B|rigid:yfPrHzSwrOnot6VCGeSKhArPsCI false flag tag:?-?(MINT-1772119) glutathione s tranferase tag:?-?(MINT-1772108)|binding-associated region:403-460(MINT-1772115) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96IF1 uniprotkb:Q9NRM7 intact:EBI-949782|intact:EBI-28987773|ensembl:ENSP00000262713|ensembl:ENSP00000354491|uniprotkb:D3DS37|uniprotkb:A8MX18 intact:EBI-3506895|uniprotkb:B1AM47|uniprotkb:Q9P2X1|ensembl:ENSP00000372035 psi-mi:ajuba_human(display_long)|uniprotkb:AJUBA(gene name)|psi-mi:AJUBA(display_short)|uniprotkb:JUB(gene name synonym) psi-mi:lats2_human(display_long)|uniprotkb:LATS2(gene name)|psi-mi:LATS2(display_short)|uniprotkb:KPM(gene name synonym)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)|uniprotkb:Warts-like kinase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Abe et al. (2006) pubmed:16413547|imex:IM-9478|mint:MINT-5218235 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8019651|mint:MINT-1772128|imex:IM-9478-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045294"(alpha-catenin binding)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|go:"GO:0030027"(lamellipodium)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0034613"(cellular protein localization)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q96IF1|go:"GO:0035195"(gene silencing by miRNA)|reactome:R-HSA-1234176|reactome:R-HSA-2565942|reactome:R-HSA-5617472|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|ensembl:ENSG00000129474(gene)|ensembl:ENST00000262713(transcript)|ensembl:ENST00000361265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_116265.1|refseq:NP_932352.1|ensembl:ENSP00000262713|ensembl:ENSP00000354491|ensembl:ENST00000397388|ensembl:ENSP00000380543|refseq:NP_001276026.1|mint:MINT-1772131(identity) refseq:NP_055387.2|ensembl:ENSG00000150457(gene)|ensembl:ENST00000382592(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR028742|rcsb pdb:4ZRI|reactome:R-HSA-2028269|ensembl:ENSP00000372035|refseq:XP_005266399.1|dip:DIP-43883N|mint:MINT-1772142(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/03/07 2014/10/16 rogid:l3GAffQ5t7Cfb9iQLE/hdyNQwbw9606 rogid:BG2iO0Zw2KutrLOqxz6pysnA2Xc9606 intact-crc:290DAD6DC9A651BD|rigid:yfPrHzSwrOnot6VCGeSKhArPsCI false binding-associated region:271-533(MINT-1772139)|flag tag:?-?(MINT-1772132) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9NRM7 uniprotkb:Q96IF1 intact:EBI-3506895|uniprotkb:B1AM47|uniprotkb:Q9P2X1|ensembl:ENSP00000372035 intact:EBI-949782|intact:EBI-28987773|ensembl:ENSP00000262713|ensembl:ENSP00000354491|uniprotkb:D3DS37|uniprotkb:A8MX18 psi-mi:lats2_human(display_long)|uniprotkb:LATS2(gene name)|psi-mi:LATS2(display_short)|uniprotkb:KPM(gene name synonym)|uniprotkb:Kinase phosphorylated during mitosis protein(gene name synonym)|uniprotkb:Large tumor suppressor homolog 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase kpm(gene name synonym)|uniprotkb:Warts-like kinase(gene name synonym) psi-mi:ajuba_human(display_long)|uniprotkb:AJUBA(gene name)|psi-mi:AJUBA(display_short)|uniprotkb:JUB(gene name synonym) psi-mi:"MI:0018"(two hybrid) Abe et al. (2006) pubmed:16413547|imex:IM-9478|mint:MINT-5218235 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8019694|mint:MINT-1778030|imex:IM-9478-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055387.2|ensembl:ENSG00000150457(gene)|ensembl:ENST00000382592(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR028742|rcsb pdb:4ZRI|reactome:R-HSA-2028269|ensembl:ENSP00000372035|refseq:XP_005266399.1|dip:DIP-43883N|mint:MINT-1778040(identity) go:"GO:0045294"(alpha-catenin binding)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|go:"GO:0030027"(lamellipodium)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0034613"(cellular protein localization)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q96IF1|go:"GO:0035195"(gene silencing by miRNA)|reactome:R-HSA-1234176|reactome:R-HSA-2565942|reactome:R-HSA-5617472|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|ensembl:ENSG00000129474(gene)|ensembl:ENST00000262713(transcript)|ensembl:ENST00000361265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_116265.1|refseq:NP_932352.1|ensembl:ENSP00000262713|ensembl:ENSP00000354491|ensembl:ENST00000397388|ensembl:ENSP00000380543|refseq:NP_001276026.1|mint:MINT-1778032(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/03/07 2014/10/16 rogid:BG2iO0Zw2KutrLOqxz6pysnA2Xc9606 rogid:l3GAffQ5t7Cfb9iQLE/hdyNQwbw9606 intact-crc:EA4A0024A3F532AD|rigid:yfPrHzSwrOnot6VCGeSKhArPsCI false tag:?-?(MINT-1778041)|binding-associated region:376-624(MINT-1778048) binding-associated region:271-533(MINT-1790013)|tag:?-?(MINT-1778033) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)