#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q4QQV2	uniprotkb:P97573	intact:EBI-8008810|intact:MINT-2517100|ensembl:ENSRNOP00000010020	intact:EBI-8008869|intact:MINT-2517198	psi-mi:dok1_rat(display_long)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)	psi-mi:ship1_rat(display_long)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2006)	pubmed:16407976|imex:IM-10783|mint:MINT-5218220	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8008861|mint:MINT-2517177|imex:IM-10783-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1309499|refseq:NP_001020587.1|ensembl:ENSRNOG00000007412(gene)|ensembl:ENSRNOT00000010020(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q4QQV2|reactome:R-RNO-8849469|reactome:R-RNO-8853659|mint:MINT-2517184(identity)	refseq:NP_062184.1|rgd:2914|mint:P97573|dip:DIP-42709N|interpro:IPR036860|reactome:R-RNO-1660499|reactome:R-RNO-1855204|reactome:R-RNO-202424|reactome:R-RNO-912526|interpro:IPR036691|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|mint:MINT-2517178(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6"|comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2006/06/12	2014/10/16	rogid:6xLdpUqzNFsdem2OY5H2FhhL5T810116	rogid:GrqXEaClAtx8mMAaxFSaC7PKznI10116	intact-crc:D49A79870D07E30D|rigid:ANtmujN9ra7uENI2hwse8J636+g	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4QQV2	uniprotkb:P50904	intact:EBI-8008810|intact:MINT-2517100|ensembl:ENSRNOP00000010020	intact:EBI-5747849	psi-mi:dok1_rat(display_long)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)	psi-mi:rasa1_rat(display_long)|uniprotkb:Rasa1(gene name)|psi-mi:Rasa1(display_short)|uniprotkb:Rasa(gene name synonym)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2006)	pubmed:16407976|imex:IM-10783|mint:MINT-5218220	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8008830|mint:MINT-2517115|imex:IM-10783-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1309499|refseq:NP_001020587.1|ensembl:ENSRNOG00000007412(gene)|ensembl:ENSRNOT00000010020(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q4QQV2|reactome:R-RNO-8849469|reactome:R-RNO-8853659|mint:MINT-2517116(identity)	rgd:3537|refseq:NP_037267.1|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR023152|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR028554|mint:P50904|interpro:IPR039360|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030539"(male genitalia development)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051020"(GTPase binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1990782"(protein tyrosine kinase binding)|reactome:R-RNO-186763|reactome:R-RNO-3928662|reactome:R-RNO-5218921|reactome:R-RNO-5658442|reactome:R-RNO-8849471|go:"GO:0048514"(blood vessel morphogenesis)|mint:MINT-2517117(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2006/06/12	2014/10/16	rogid:6xLdpUqzNFsdem2OY5H2FhhL5T810116	rogid:bPQVnB+sC99xPSbNxpVjvlPg3Xs10116	intact-crc:A7EB70B47BBD3F51|rigid:q3jq5WYHbUQBGLHWR3p0K8kPfow	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4QQV2	uniprotkb:O70143	intact:EBI-8008810|intact:MINT-2517100|ensembl:ENSRNOP00000010020	intact:EBI-8008907|intact:MINT-2517226	psi-mi:dok1_rat(display_long)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)	psi-mi:shc3_rat(display_long)|uniprotkb:Shc3(gene name)|psi-mi:Shc3(display_short)|uniprotkb:Nshc(gene name synonym)|uniprotkb:Shcc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C3(gene name synonym)|uniprotkb:Neuronal Shc(gene name synonym)|uniprotkb:SHC-transforming protein C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2006)	pubmed:16407976|imex:IM-10783|mint:MINT-5218220	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8008899|mint:MINT-2517211|imex:IM-10783-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1309499|refseq:NP_001020587.1|ensembl:ENSRNOG00000007412(gene)|ensembl:ENSRNOT00000010020(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q4QQV2|reactome:R-RNO-8849469|reactome:R-RNO-8853659|mint:MINT-2517218(identity)	rgd:69348|interpro:IPR029593|mint:O70143|interpro:IPR035676|interpro:IPR036860|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035249"(synaptic transmission, glutamatergic)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0045202"(synapse)|reactome:R-RNO-167044|reactome:R-RNO-5673001|reactome:R-RNO-8853659|go:"GO:0035556"(intracellular signal transduction)|mint:MINT-2517212(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2006/06/12	2014/10/16	rogid:6xLdpUqzNFsdem2OY5H2FhhL5T810116	rogid:Eku+Dh8UphP1mUAkTxgsMLJu/ik10116	intact-crc:C169057D90ED97DF|rigid:bxtQnxwrL8TB0AwhoarrU4rjiis	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97573	uniprotkb:O70469	intact:EBI-8008869|intact:MINT-2517198	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	psi-mi:ship1_rat(display_long)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2006)	pubmed:16407976|imex:IM-10783|mint:MINT-5218220	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8008969|mint:MINT-2517294|imex:IM-10783-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062184.1|rgd:2914|mint:P97573|dip:DIP-42709N|interpro:IPR036860|reactome:R-RNO-1660499|reactome:R-RNO-1855204|reactome:R-RNO-202424|reactome:R-RNO-912526|interpro:IPR036691|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|mint:MINT-2517301(identity)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659|mint:MINT-2517295(identity)	-	comment:mint|function:"Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:Since in not available the rat UP_Id for Dok-2 it was used the murine identifier|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2006/06/12	2014/10/16	rogid:GrqXEaClAtx8mMAaxFSaC7PKznI10116	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	intact-crc:1639232D89141F01|rigid:NU9Gx2Mo9HpFbGR2z4eP68ls7Qc	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50904	uniprotkb:O70469	intact:EBI-5747849	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	psi-mi:rasa1_rat(display_long)|uniprotkb:Rasa1(gene name)|psi-mi:Rasa1(display_short)|uniprotkb:Rasa(gene name synonym)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2006)	pubmed:16407976|imex:IM-10783|mint:MINT-5218220	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8008938|mint:MINT-2517256|imex:IM-10783-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3537|refseq:NP_037267.1|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR023152|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR028554|mint:P50904|interpro:IPR039360|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030539"(male genitalia development)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051020"(GTPase binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1990782"(protein tyrosine kinase binding)|reactome:R-RNO-186763|reactome:R-RNO-3928662|reactome:R-RNO-5218921|reactome:R-RNO-5658442|reactome:R-RNO-8849471|go:"GO:0048514"(blood vessel morphogenesis)|mint:MINT-2517257(identity)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659|mint:MINT-2517263(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:Since in not available the rat UP_Id for Dok-2 it was used the murine identifier|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2006/06/12	2014/10/16	rogid:bPQVnB+sC99xPSbNxpVjvlPg3Xs10116	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	intact-crc:454FA586D1BE402A|rigid:UlSqddeEnNeZwvLVbh0B1nf1W6s	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70143	uniprotkb:O70469	intact:EBI-8008907|intact:MINT-2517226	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	psi-mi:shc3_rat(display_long)|uniprotkb:Shc3(gene name)|psi-mi:Shc3(display_short)|uniprotkb:Nshc(gene name synonym)|uniprotkb:Shcc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C3(gene name synonym)|uniprotkb:Neuronal Shc(gene name synonym)|uniprotkb:SHC-transforming protein C(gene name synonym)	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2006)	pubmed:16407976|imex:IM-10783|mint:MINT-5218220	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8008983|mint:MINT-2517314|imex:IM-10783-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69348|interpro:IPR029593|mint:O70143|interpro:IPR035676|interpro:IPR036860|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035249"(synaptic transmission, glutamatergic)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0045202"(synapse)|reactome:R-RNO-167044|reactome:R-RNO-5673001|reactome:R-RNO-8853659|go:"GO:0035556"(intracellular signal transduction)|mint:MINT-2517315(identity)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659|mint:MINT-2517321(identity)	-	function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:Since in not available the rat UP_Id for Dok-2 it was used the murine identifier|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2006/06/12	2014/10/16	rogid:Eku+Dh8UphP1mUAkTxgsMLJu/ik10116	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	intact-crc:7104B9279A308934|rigid:5K6IXJFXBirbRWAIb1HgdSo3y40	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)