#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60848	uniprotkb:O88508	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987525|mint:MINT-2521061|imex:IM-11493-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2521062(identity)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N|mint:MINT-2521063(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	intact-crc:830C2C0AFF2324BA|rigid:eFJHX+aSLFo1h9n3JVQM5fo9FMY	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:O88509	uniprotkb:Q60848	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987539|mint:MINT-2523301|imex:IM-11493-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427|mint:MINT-2523304(identity)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2523311(identity)	-	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	intact-crc:B504BD4D69E25416|rigid:AxIKDTeboA3bxK1xwHP6KVNIJ3s	false	-	-	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q60848	uniprotkb:O88508	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987609|mint:MINT-2523996|imex:IM-11493-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2524004(identity)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N|mint:MINT-2523997(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	intact-crc:6F3F7948A2A2AAC5|rigid:eFJHX+aSLFo1h9n3JVQM5fo9FMY	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:O88509	uniprotkb:Q60848	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987623|mint:MINT-2524477|imex:IM-11493-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427|mint:MINT-2524479(identity)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2524487(identity)	-	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	intact-crc:69244B5058F22F14|rigid:AxIKDTeboA3bxK1xwHP6KVNIJ3s	false	-	-	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88509	uniprotkb:Q60848	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987660|mint:MINT-2524736|imex:IM-11493-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427|mint:MINT-2524737(identity)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2524743(identity)	-	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	intact-crc:0E56E8E8B123F799|rigid:AxIKDTeboA3bxK1xwHP6KVNIJ3s	false	myc tag:?-?(MINT-2524758)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q60848	uniprotkb:O88508	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987637|mint:MINT-2524712|imex:IM-11493-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2524719(identity)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N|mint:MINT-2524713(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	intact-crc:9BD9109044C19576|rigid:eFJHX+aSLFo1h9n3JVQM5fo9FMY	false	-	myc tag:?-?(MINT-2524733)	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88508	uniprotkb:Q60848	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987743|mint:MINT-2524762|imex:IM-11493-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N|mint:MINT-2524763(identity)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2524771(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	intact-crc:54EAE9D53CB4F3E5|rigid:eFJHX+aSLFo1h9n3JVQM5fo9FMY	false	myc tag:?-?(MINT-2524767)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88509	uniprotkb:Q60848	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhu et al. (2006)	pubmed:16395332|imex:IM-11493|mint:MINT-5218197	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7987760|mint:MINT-2524790|imex:IM-11493-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427|mint:MINT-2524791(identity)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N|mint:MINT-2524799(identity)	-	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2006/06/13	2014/10/16	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	intact-crc:A66C968D1914B5EC|rigid:AxIKDTeboA3bxK1xwHP6KVNIJ3s	false	myc tag:?-?(MINT-2524795)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)