#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96FW1 uniprotkb:Q9RI12 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-2849107|uniprotkb:O68717|ensemblbacteria:AAS58532 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:ypka_yerpe(display_long)|uniprotkb:ypkA(gene name)|psi-mi:ypkA(display_short)|uniprotkb:Targeted effector protein kinase(gene name synonym)|uniprotkb:YPCD1.72c(locus name)|uniprotkb:y5008(locus name)|uniprotkb:y0009(locus name)|uniprotkb:YP_pCD13(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Juris et al. (2006) pubmed:16364312|imex:IM-11026|mint:MINT-5218152 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:632(yerpe)|taxid:632(Yersinia pestis) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7968642|mint:MINT-73525|imex:IM-11026-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N|mint:MINT-1503432(identity) refseq:WP_002213290.1|refseq:NP_395206.1|refseq:NP_857776.1|refseq:NP_857907.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR019093|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|refseq:WP_011114033.1|ensemblbacteria:AAS58532(transcript)|ensemblbacteria:YP_pCD13(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR043119|interpro:IPR043120|mint:MINT-1503423(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/01/13 2014/10/16 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:nPxkaYGmknZ8HLutwXFqE35m9B0632 intact-crc:810BA73CDF459B02|rigid:fOb2vzKnU9KF1qi+m5AY+9gndE0 false ha tag:?-?(MINT-1503433) flag tag:?-?(MINT-1503426)|mutation:269-269(MINT-1503424) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9RI12 uniprotkb:Q96FW1 intact:EBI-2849107|uniprotkb:O68717|ensemblbacteria:AAS58532 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 psi-mi:ypka_yerpe(display_long)|uniprotkb:ypkA(gene name)|psi-mi:ypkA(display_short)|uniprotkb:Targeted effector protein kinase(gene name synonym)|uniprotkb:YPCD1.72c(locus name)|uniprotkb:y5008(locus name)|uniprotkb:y0009(locus name)|uniprotkb:YP_pCD13(locus name) psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:"MI:0424"(protein kinase assay) Juris et al. (2006) pubmed:16364312|imex:IM-11026|mint:MINT-5218152 taxid:632(yerpe)|taxid:632(Yersinia pestis) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7968721|mint:MINT-73527|imex:IM-11026-2 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_002213290.1|refseq:NP_395206.1|refseq:NP_857776.1|refseq:NP_857907.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR019093|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|refseq:WP_011114033.1|ensemblbacteria:AAS58532(transcript)|ensemblbacteria:YP_pCD13(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR043119|interpro:IPR043120|mint:MINT-1503445(identity) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N|mint:MINT-1503450(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4|comment:Phosphorylation only in presence of actin|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/13 2014/10/16 rogid:nPxkaYGmknZ8HLutwXFqE35m9B0632 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 intact-crc:FD85DE1AB50702BD|rigid:fOb2vzKnU9KF1qi+m5AY+9gndE0 false - - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96FW1 uniprotkb:Q9RI12 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-2849107|uniprotkb:O68717|ensemblbacteria:AAS58532 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:ypka_yerpe(display_long)|uniprotkb:ypkA(gene name)|psi-mi:ypkA(display_short)|uniprotkb:Targeted effector protein kinase(gene name synonym)|uniprotkb:YPCD1.72c(locus name)|uniprotkb:y5008(locus name)|uniprotkb:y0009(locus name)|uniprotkb:YP_pCD13(locus name) psi-mi:"MI:0004"(affinity chromatography technology) Juris et al. (2006) pubmed:16364312|imex:IM-11026|mint:MINT-5218152 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:632(yerpe)|taxid:632(Yersinia pestis) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7968761|mint:MINT-73524|imex:IM-11026-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N|mint:MINT-1503469(identity) refseq:WP_002213290.1|refseq:NP_395206.1|refseq:NP_857776.1|refseq:NP_857907.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR019093|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|refseq:WP_011114033.1|ensemblbacteria:AAS58532(transcript)|ensemblbacteria:YP_pCD13(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR043119|interpro:IPR043120|mint:MINT-1503462(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2 F3A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/13 2014/10/16 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:nPxkaYGmknZ8HLutwXFqE35m9B0632 intact-crc:712742D6DC9909BA|rigid:fOb2vzKnU9KF1qi+m5AY+9gndE0 false - tag:?-?(MINT-1503463) 1 1 psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0078"(nucleotide sequence identification)