#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9QZS8 uniprotkb:Q63767 intact:EBI-7964037|uniprotkb:A2AK84|intact:MINT-1503279|uniprotkb:Q9JME1|ensembl:ENSMUSP00000073866 intact:EBI-1176801|uniprotkb:Q63766 psi-mi:sh2d3_mouse(display_long)|uniprotkb:Sh2d3c(gene name)|psi-mi:Sh2d3c(display_short)|uniprotkb:Chat(gene name synonym)|uniprotkb:Shep1(gene name synonym)|uniprotkb:SH2 domain-containing Eph receptor-binding protein 1(gene name synonym)|uniprotkb:Cas/HEF1-associated signal transducer(gene name synonym) psi-mi:bcar1_rat(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:Bcar1(gene name)|psi-mi:Bcar1(display_short)|uniprotkb:Cas(gene name synonym)|uniprotkb:Crkas(gene name synonym) psi-mi:"MI:0096"(pull down) Derunes et al. (2006) pubmed:16364304|imex:IM-10884|mint:MINT-5218142 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7964031|mint:MINT-74856|imex:IM-10884-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038809.1|refseq:NP_001239476.1|dip:DIP-42657N|ensembl:ENSMUSG00000059013(gene)|ensembl:ENSMUST00000074248(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030424"(axon)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102|mint:MINT-1503302(identity) rgd:2406|refseq:NP_037063.1|interpro:IPR021901|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR001452(Src homology-3)|rcsb pdb:1X27|rcsb pdb:1Z23|interpro:IPR037362|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR038319|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|reactome:R-RNO-186763|reactome:R-RNO-372708|reactome:R-RNO-4420097|reactome:R-RNO-8849471|mint:MINT-1503292(identity) - comment:mint|function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2006/01/17 2014/10/16 rogid:EQM1e5BcyjOWCUs97MgXL5cmtHw10090 rogid:PwKKuaIaJmydKfuFPz05hT1UUow10116 intact-crc:1272C87FB17DE2A2|rigid:O7Yr5aqXd9JpgZubMi5dRT01bxk false glutathione s tranferase tag:?-?(MINT-1503306)|binding-associated region:362-702(MINT-1503303) binding-associated region:836-968(MINT-1503293)|his tag:?-?(MINT-1503296) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)