#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10636-8	uniprotkb:P23443-2	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	intact:EBI-6093204	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:p23443-2(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pei et al. (2006)	pubmed:16364302|imex:IM-11246|mint:MINT-5218138	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7961005|mint:MINT-74874|imex:IM-11246-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)|mint:MINT-1503247(identity)	intact:EBI-1775921(isoform-parent)|uniprotkb:P23443-2(isoform-parent)|mint:MINT-1503238(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:Fig. 3|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2006/01/17	2014/10/24	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rogid:94A65Rjqrfodwc+1my5vsEwCvVc9606	intact-crc:EC98B6ADAEDE1A92|rigid:ZWUlDDm30YxAeI240VbwIv0fFlo	false	O-phospho-L-serine:262-262(MINT-1503248)|O-phospho-L-serine:396-396|O-phospho-L-serine:404-404	O-phospho-L-serine:424-424(MINT-1503239)|O-phospho-L-threonine:421-421(MINT-1503241)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P23443	uniprotkb:P10636-8	intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym)	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Pei et al. (2006)	pubmed:16364302|imex:IM-11246|mint:MINT-5218138	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7961067|mint:MINT-74872|imex:IM-11246-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208|mint:MINT-1503260(identity)	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)|mint:MINT-1503265(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:Fig. 2b|resulting-ptm:P10636-8 thr-212 O-phospho-L-threonine|resulting-ptm:P10636-8 ser-214 O-phospho-L-serine|resulting-ptm:P10636-8 ser-262 O-phospho-L-serine|comment:homomint|comment:mint|causality statement:P23443 is required for phosphorylation of P10636-8|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/17	2014/10/23	rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	intact-crc:D68F9B31ED5ABD80|rigid:juDRLwcHtrvfvbiZtMPK7db/bJo	false	mutation:412-412	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)