#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y3R0	uniprotkb:Q14653	intact:EBI-5349621|uniprotkb:C9JT59|uniprotkb:Q1RLM0|ensembl:ENSP00000352780	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	psi-mi:grip1_human(display_long)|uniprotkb:GRIP1(gene name)|psi-mi:GRIP1(display_short)	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:"MI:0018"(two hybrid)	Reily et al. (2006)	pubmed:16362036|imex:IM-11273|mint:MINT-5218117	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7946914|mint:MINT-2736988|imex:IM-11273-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536395.1|refseq:NP_001171545.1|refseq:NP_066973.2|ensembl:ENSG00000155974(gene)|ensembl:ENST00000359742(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q9Y3R0|rcsb pdb:2JIL|reactome:R-HSA-416993|mint:MINT-2736989(identity)	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N|mint:MINT-2736990(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1E|figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/07/03	2014/10/16	rogid:BBMxSfND5Mr47/EoX8y0RmCQjCc9606	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	intact-crc:1B946207A624DA77|rigid:vk9CtbH4r3u7HHavaNOMVGaIpsg	false	binding-associated region:?-?(MINT-2737013)|tag:?-?(MINT-2737006)	tag:?-?(MINT-2736996)|binding-associated region:188-427(MINT-2737003)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14653	uniprotkb:Q9Y3R0	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	intact:EBI-5349621|uniprotkb:C9JT59|uniprotkb:Q1RLM0|ensembl:ENSP00000352780	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:grip1_human(display_long)|uniprotkb:GRIP1(gene name)|psi-mi:GRIP1(display_short)	psi-mi:"MI:0096"(pull down)	Reily et al. (2006)	pubmed:16362036|imex:IM-11273|mint:MINT-5218117	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7946957|mint:MINT-2737016|imex:IM-11273-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N|mint:MINT-2737027(identity)	refseq:XP_011536395.1|refseq:NP_001171545.1|refseq:NP_066973.2|ensembl:ENSG00000155974(gene)|ensembl:ENST00000359742(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q9Y3R0|rcsb pdb:2JIL|reactome:R-HSA-416993|mint:MINT-2737017(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1D|figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/03	2014/10/16	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	rogid:BBMxSfND5Mr47/EoX8y0RmCQjCc9606	intact-crc:333ED04353482DB4|rigid:vk9CtbH4r3u7HHavaNOMVGaIpsg	false	binding-associated region:188-427(MINT-2737028)|glutathione s tranferase tag:?-?(MINT-2737035)	binding-associated region:?-?(MINT-2737018)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04150	uniprotkb:Q9Y3R0	intact:EBI-493507|uniprotkb:P04151|uniprotkb:Q53EP5|uniprotkb:Q6N0A4|uniprotkb:B0LPG8|uniprotkb:D3DQF4|uniprotkb:A0ZXF9|uniprotkb:F5ATB7|ensembl:ENSP00000343205|ensembl:ENSP00000377977|ensembl:ENSP00000427672	intact:EBI-5349621|uniprotkb:C9JT59|uniprotkb:Q1RLM0|ensembl:ENSP00000352780	psi-mi:gcr_human(display_long)|uniprotkb:Nuclear receptor subfamily 3 group C member 1(gene name synonym)|uniprotkb:NR3C1(gene name)|psi-mi:NR3C1(display_short)|uniprotkb:GRL(gene name synonym)	psi-mi:grip1_human(display_long)|uniprotkb:GRIP1(gene name)|psi-mi:GRIP1(display_short)	psi-mi:"MI:0096"(pull down)	Reily et al. (2006)	pubmed:16362036|imex:IM-11273|mint:MINT-5218117	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7946988|mint:MINT-2737273|imex:IM-11273-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000167.1|refseq:NP_001018084.1|refseq:NP_001018085.1|refseq:NP_001018086.1|refseq:NP_001018087.1|refseq:NP_001018661.1|refseq:NP_001019265.1|refseq:NP_001191187.1|refseq:NP_001191188.1|refseq:NP_001191189.1|refseq:NP_001191190.1|refseq:NP_001191191.1|refseq:NP_001191192.1|refseq:NP_001191193.1|refseq:XP_005268476.1|refseq:XP_005268477.1|refseq:XP_005268479.1|refseq:XP_005268480.1|ensembl:ENSG00000113580(gene)|ensembl:ENST00000343796(transcript)|ensembl:ENST00000394464(transcript)|ensembl:ENST00000503201(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007165"(signal transduction)|rcsb pdb:5E69|rcsb pdb:5E6A|rcsb pdb:5E6B|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|rcsb pdb:5E6C|rcsb pdb:5E6D|go:"GO:0019901"(protein kinase binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001409(Glucocorticoid receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P04150|rcsb pdb:1M2Z|rcsb pdb:1NHZ|rcsb pdb:1P93|rcsb pdb:3BQD|rcsb pdb:3CLD|rcsb pdb:3E7C|rcsb pdb:3H52|rcsb pdb:3K22|rcsb pdb:3K23|rcsb pdb:4CSJ|rcsb pdb:4HN5|rcsb pdb:4HN6|rcsb pdb:4LSJ|rcsb pdb:4MDD|rcsb pdb:4P6W|rcsb pdb:4P6X|rcsb pdb:4UDC|rcsb pdb:4UDD|rcsb pdb:5CBX|rcsb pdb:5CBY|rcsb pdb:5CBZ|rcsb pdb:5CC1|refseq:XP_016864886.1|refseq:XP_016864887.1|rcsb pdb:5EMC|rcsb pdb:5EMP|rcsb pdb:5EMQ|rcsb pdb:5G3J|rcsb pdb:5G5W|rcsb pdb:5NFP|rcsb pdb:5NFT|rcsb pdb:5UC3|rcsb pdb:5VA0|rcsb pdb:5VA7|rcsb pdb:6BQU|rcsb pdb:6CFN|rcsb pdb:6DXK|rcsb pdb:6EL6|rcsb pdb:6EL7|rcsb pdb:6EL9|rcsb pdb:6X6D|rcsb pdb:6X6E|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6YOS|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-8849473|reactome:R-HSA-8939902|reactome:R-HSA-9615017|reactome:R-HSA-9679191|dip:DIP-576N|mint:MINT-2737283(identity)	refseq:XP_011536395.1|refseq:NP_001171545.1|refseq:NP_066973.2|ensembl:ENSG00000155974(gene)|ensembl:ENST00000359742(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q9Y3R0|rcsb pdb:2JIL|reactome:R-HSA-416993|mint:MINT-2737274(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/03	2014/10/16	rogid:4IOUe8VfG++O0M9uS6phAd8TBzw9606	rogid:BBMxSfND5Mr47/EoX8y0RmCQjCc9606	intact-crc:6508926B315025B0|rigid:9aDiyHmPKXE8N9tUykUyVYXf7Fc	false	-	binding-associated region:?-?(MINT-2737275)|his tag:?-?(MINT-2737279)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70671	uniprotkb:Q925T6	intact:EBI-7947049|intact:MINT-2737174|ensembl:ENSMUSP00000003284|ensembl:ENSMUSP00000103465|ensembl:ENSMUSP00000146773	intact:EBI-537752|uniprotkb:Q8BLQ3|uniprotkb:Q8C0T3|uniprotkb:Q925T5|uniprotkb:Q925T7|ensembl:ENSMUSP00000123234	psi-mi:irf3_mouse(display_long)|uniprotkb:Irf3(gene name)|psi-mi:Irf3(display_short)	psi-mi:grip1_mouse(display_long)|uniprotkb:Grip1(gene name)|psi-mi:Grip1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Reily et al. (2006)	pubmed:16362036|imex:IM-11273|mint:MINT-5218117	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7947041|mint:MINT-2737152|imex:IM-11273-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058545.1|refseq:XP_006541058.1|refseq:XP_006541059.1|dip:DIP-29881N|ensembl:ENSMUSG00000003184(gene)|ensembl:ENSMUST00000003284(transcript)|ensembl:ENSMUST00000107834(transcript)|ensembl:ENSMUST00000209066(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009617"(response to bacterium)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|mint:P70671|rcsb pdb:7JFM|reactome:R-MMU-1169408|reactome:R-MMU-1606341|reactome:R-MMU-168928|reactome:R-MMU-3134973|reactome:R-MMU-3134975|reactome:R-MMU-3270619|reactome:R-MMU-9013973|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-936440|reactome:R-MMU-936964|interpro:IPR036390|mint:MINT-2737160(identity)	refseq:NP_001264224.1|refseq:NP_083012.1|refseq:NP_570961.1|refseq:NP_597699.1|refseq:NP_001264221.1|refseq:NP_001264223.1|ensembl:ENSMUSG00000034813(gene)|ensembl:ENSMUST00000138410(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q925T6|rcsb pdb:1V5Q|reactome:R-MMU-416993|mint:MINT-2737153(identity)	-	comment:mint|comment:homomint|function:"Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2006/07/03	2014/10/16	rogid:xmGnU7D+q5tJfXGdJWnPOZHdD4I10090	rogid:nQDCS/yQb0DlZs+60Vf3Q3hbECk10090	intact-crc:717C6D1825715784|rigid:1FdEUug/KA0Pm38ly+gbAlXbV6w	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)