#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51023	uniprotkb:P40417	intact:EBI-154079|uniprotkb:B9EQV8|uniprotkb:Q29R53|uniprotkb:Q8IG92|uniprotkb:Q9VCN2|uniprotkb:Q8IMZ1|intact:EBI-870003|uniprotkb:A0A0B4KH96|uniprotkb:H8F4R1|uniprotkb:P19420|uniprotkb:P51022|ensemblmetazoa:FBpp0088658	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:pnt_drome(display_long)|uniprotkb:pnt(gene name)|psi-mi:pnt(display_short)|uniprotkb:ETS2(gene name synonym)|uniprotkb:Ets58AB(gene name synonym)|uniprotkb:DMPOINT1A(gene name synonym)|uniprotkb:pointed(gene name synonym)|uniprotkb:CG17077(orf name)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Qiao et al. (2006)	pubmed:16362034|imex:IM-13922|mint:MINT-5218114	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7945831|mint:MINT-2737432|imex:IM-13922-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524461.2|refseq:NP_732857.1|flybase:FBgn0003118|ensemblmetazoa:FBgn0003118(gene)|ensemblmetazoa:FBtr0089717(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001742"(oenocyte differentiation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0007464"(R3/R4 cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009997"(negative regulation of cardioblast cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0035154"(terminal cell fate specification, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0007428"(primary branching, open tracheal system)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0007429"(secondary branching, open tracheal system)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060438"(trachea development)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:0090175"(regulation of establishment of planar polarity)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000418(Ets)|interpro:IPR003118(Sterile alpha motif/pointed)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036388|interpro:IPR036390|mint:P51023|reactome:R-DME-2559585|go:"GO:0043697"(cell dedifferentiation)|dip:DIP-19576N|refseq:NP_001262872.1|refseq:NP_732858.1|mint:MINT-2737434(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-2737433(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1D|figure legend:F1C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/03	2014/10/16	rogid:CHksMmvAXZCAMhi61vR2ZtWY5aQ7227	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:2AA8E4359E37AFD3|rigid:2ojWgtr3UGR6BFKuSGqG18AzPHc	false	mutation disrupting interaction:151-151(MINT-2737516)|mutation decreasing interaction:234-234(MINT-2737522)|binding-associated region:166-250(MINT-2737475)|mutation decreasing interaction:228-228(MINT-2737519)	binding-associated region:18-375(MINT-2737533)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)