#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49185	uniprotkb:Q9R237	intact:EBI-7456505|intact:MINT-1500743	intact:EBI-7936746|uniprotkb:Q9WVI5|uniprotkb:Q9WVI6|uniprotkb:Q9R1H8|intact:MINT-1500684|uniprotkb:O88979|uniprotkb:B0VXR5	psi-mi:mk08_rat(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:SAPK gamma(gene name synonym)|uniprotkb:p54 gamma(gene name synonym)	psi-mi:jip1_rat(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:JIP-1-related protein(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nishitani et al. (2006)	pubmed:16343492|imex:IM-11214|mint:MINT-5218101	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7936738|mint:MINT-73542|imex:IM-11214-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_446281.2|mint:P49185|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|rgd:621506|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|reactome:R-RNO-111446|reactome:R-RNO-139910|reactome:R-RNO-193648|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-450321|reactome:R-RNO-450341|reactome:R-RNO-5693565|reactome:R-RNO-9007892|mint:MINT-1500760(identity)	rgd:70937|refseq:NP_446229.1|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|rcsb pdb:2FPD|rcsb pdb:2FPE|rcsb pdb:2FPF|interpro:IPR035638|interpro:IPR036028|mint:Q9R237|mint:MINT-1500765(identity)	-	function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4)"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response"|comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Livers were treated with 50mM ethanol, in presence or absence of 4 mM of 4-methyl pyrazole.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2006/01/13	2014/10/16	rogid:wxHOU4BGM+BVCEKEwcYoNqxvIfo10116	rogid:Z2R2Emnn4cNS/+BPbOhadQC1EK810116	intact-crc:4BD267E7482F78BE|rigid:JiDMfHwL1Gyd/IaOrje9fJ2iBz0	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47196	uniprotkb:Q9R237	intact:EBI-7204362|ensembl:ENSRNOP00000038369|intact:MINT-1210360	intact:EBI-7936746|uniprotkb:Q9WVI5|uniprotkb:Q9WVI6|uniprotkb:Q9R1H8|intact:MINT-1500684|uniprotkb:O88979|uniprotkb:B0VXR5	psi-mi:akt1_rat(display_long)|uniprotkb:Akt1(gene name)|psi-mi:Akt1(display_short)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:jip1_rat(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:JIP-1-related protein(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nishitani et al. (2006)	pubmed:16343492|imex:IM-11214|mint:MINT-5218101	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7936797|mint:MINT-73543|imex:IM-11214-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006240693.1|ensembl:ENSRNOG00000028629(gene)|ensembl:ENSRNOT00000031164(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005977"(glycogen metabolic process)|rgd:2081|refseq:NP_150233.1|reactome:R-RNO-6811558|reactome:R-RNO-69202|reactome:R-RNO-69656|reactome:R-RNO-8849469|reactome:R-RNO-8876198|reactome:R-RNO-8948751|reactome:R-RNO-9009391|reactome:R-RNO-9604323|reactome:R-RNO-9607240|reactome:R-RNO-9614399|reactome:R-RNO-9634638|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010467"(gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030030"(cell projection organization)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P47196|reactome:R-RNO-1257604|reactome:R-RNO-1358803|reactome:R-RNO-1474151|reactome:R-RNO-165159|reactome:R-RNO-198323|reactome:R-RNO-198693|reactome:R-RNO-199418|reactome:R-RNO-203615|reactome:R-RNO-211163|reactome:R-RNO-354192|reactome:R-RNO-3769402|reactome:R-RNO-389357|reactome:R-RNO-389513|reactome:R-RNO-392451|reactome:R-RNO-450385|reactome:R-RNO-450604|reactome:R-RNO-5218920|reactome:R-RNO-5628897|reactome:R-RNO-6804757|reactome:R-RNO-6804758|reactome:R-RNO-6804759|dip:DIP-42185N|mint:MINT-1500728(identity)	rgd:70937|refseq:NP_446229.1|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|rcsb pdb:2FPD|rcsb pdb:2FPE|rcsb pdb:2FPF|interpro:IPR035638|interpro:IPR036028|mint:Q9R237|mint:MINT-1500733(identity)	-	comment:mint|comment:homomint|function:"General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I (By similarity). Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase"|comment:"Stoichiometry: 1.0"	comment:mint|function:"The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response"|comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Livers were treated with 50mM ethanol, in presence or absence of 4 mM of 4-methyl pyrazole.<br>The interaction is enhanced by Akt1 phosphorylation.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2006/01/13	2014/10/16	rogid:7NwH6FjxffZSBmyueZwPBB3n8h410116	rogid:Z2R2Emnn4cNS/+BPbOhadQC1EK810116	intact-crc:7B3B3CAAF809661E|rigid:UFZXOWKPN8Qw6XOtsv2fikxRHyo	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)