#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:B2GV74 uniprotkb:O35668-2 intact:EBI-978371|ensembl:ENSRNOP00000050555 intact:EBI-473719|ensembl:ENSMUSP00000099413 psi-mi:b2gv74_rat(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short)|uniprotkb:Klc2_predicted(gene name synonym)|uniprotkb:rCG_48462(orf name) psi-mi:o35668-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:"MI:0018"(two hybrid) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-994290|imex:IM-14428-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000020299(gene)|ensembl:ENSRNOT00000041238(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|reactome:R-RNO-2132295|reactome:R-RNO-5625970|reactome:R-RNO-6811434|reactome:R-RNO-983189|refseq:XP_006223670.1|refseq:XP_006223671.1|refseq:XP_006223672.1|refseq:XP_006223673.1|refseq:XP_006230996.1|refseq:XP_006230997.1|refseq:XP_006230998.1|refseq:XP_006230999.1|refseq:XP_003749090.1|refseq:XP_003749091.1|refseq:XP_003753425.1|refseq:XP_003753426.1|rgd:1307377|refseq:XP_017445775.1|refseq:XP_017459758.1|dip:DIP-59340N intact:EBI-473704(hap1_mouse)|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000103124(transcript) psi-mi:"MI:0469"(intact) - isoform-comment:Contains a phosphothreonine at position 598. figure legend:1|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/07/26 2014/10/16 rogid:kVHNcKrsZtzhsauo5ts6nPaQb9w10116 rogid:+hWyU6CmJ+N5z7MooezHFcILh0010090 intact-crc:02FF0813EA430CA1|rigid:J6X1W8VA82dlbszQXoo29St9MpA false sufficient binding region:80-396 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O35668-2 uniprotkb:B2GV74 intact:EBI-473719|ensembl:ENSMUSP00000099413 intact:EBI-978371|ensembl:ENSRNOP00000050555 psi-mi:o35668-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:b2gv74_rat(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short)|uniprotkb:Klc2_predicted(gene name synonym)|uniprotkb:rCG_48462(orf name) psi-mi:"MI:0018"(two hybrid) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-994319|imex:IM-14428-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-473704(hap1_mouse)|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000103124(transcript) ensembl:ENSRNOG00000020299(gene)|ensembl:ENSRNOT00000041238(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|reactome:R-RNO-2132295|reactome:R-RNO-5625970|reactome:R-RNO-6811434|reactome:R-RNO-983189|refseq:XP_006223670.1|refseq:XP_006223671.1|refseq:XP_006223672.1|refseq:XP_006223673.1|refseq:XP_006230996.1|refseq:XP_006230997.1|refseq:XP_006230998.1|refseq:XP_006230999.1|refseq:XP_003749090.1|refseq:XP_003749091.1|refseq:XP_003753425.1|refseq:XP_003753426.1|rgd:1307377|refseq:XP_017445775.1|refseq:XP_017459758.1|dip:DIP-59340N psi-mi:"MI:0469"(intact) isoform-comment:Contains a phosphothreonine at position 598. - figure legend:1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/07/26 2014/10/16 rogid:+hWyU6CmJ+N5z7MooezHFcILh0010090 rogid:kVHNcKrsZtzhsauo5ts6nPaQb9w10116 intact-crc:FDC7EF29992CC494|rigid:J6X1W8VA82dlbszQXoo29St9MpA false sufficient binding region:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B2GV74 uniprotkb:O35668-2 intact:EBI-978371|ensembl:ENSRNOP00000050555 intact:EBI-473719|ensembl:ENSMUSP00000099413 psi-mi:b2gv74_rat(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short)|uniprotkb:Klc2_predicted(gene name synonym)|uniprotkb:rCG_48462(orf name) psi-mi:o35668-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:"MI:0096"(pull down) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-994334|imex:IM-14428-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000020299(gene)|ensembl:ENSRNOT00000041238(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|reactome:R-RNO-2132295|reactome:R-RNO-5625970|reactome:R-RNO-6811434|reactome:R-RNO-983189|refseq:XP_006223670.1|refseq:XP_006223671.1|refseq:XP_006223672.1|refseq:XP_006223673.1|refseq:XP_006230996.1|refseq:XP_006230997.1|refseq:XP_006230998.1|refseq:XP_006230999.1|refseq:XP_003749090.1|refseq:XP_003749091.1|refseq:XP_003753425.1|refseq:XP_003753426.1|rgd:1307377|refseq:XP_017445775.1|refseq:XP_017459758.1|dip:DIP-59340N intact:EBI-473704(hap1_mouse)|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000103124(transcript) psi-mi:"MI:0469"(intact) - isoform-comment:Contains a phosphothreonine at position 598. figure legend:1C|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/26 2014/10/16 rogid:kVHNcKrsZtzhsauo5ts6nPaQb9w10116 rogid:+hWyU6CmJ+N5z7MooezHFcILh0010090 intact-crc:74BC27F236E774BD|rigid:J6X1W8VA82dlbszQXoo29St9MpA false - glutathione s tranferase tag:?-?|sufficient binding region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35668 uniprotkb:O88447 intact:EBI-473704|uniprotkb:O35636|ensembl:ENSMUSP00000133356 intact:EBI-301550 psi-mi:hap1_mouse(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:klc1_mouse(display_long)|uniprotkb:Klc1(gene name)|psi-mi:Klc1(display_short)|uniprotkb:Kns2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-994453|imex:IM-14428-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034534.1|refseq:NP_817090.1|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000138603(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|mint:O35668|go:"GO:0030425"(dendrite)|dip:DIP-32510N mint:O88447|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043227"(membrane-bounded organelle)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:6FUZ|rcsb pdb:6FV0|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|dip:DIP-31520N psi-mi:"MI:0469"(intact) - - figure legend:1D|comment:The antibody used reacts with both KLC-1 and KLC-2 in the brain. KLC-1 is the major form of KLC in the hypothalamus and was coprecipitated by the antibody to HAP1.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2006/07/26 2014/10/16 rogid:mrrVufzrFAAiuT8yarD5JfWlRbc10090 rogid:YFYhenefPpzqNvaDB3e6plPlGQo10090 intact-crc:C8FC8E8AF427EADC|rigid:crQvqnjblgblQXRkBSXI2eCG52g false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35668 uniprotkb:O88448 intact:EBI-473704|uniprotkb:O35636|ensembl:ENSMUSP00000133356 intact:EBI-301558 psi-mi:hap1_mouse(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:klc2_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-994453|imex:IM-14428-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034534.1|refseq:NP_817090.1|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000138603(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|mint:O35668|go:"GO:0030425"(dendrite)|dip:DIP-32510N mint:O88448|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|rcsb pdb:3ZFW|rcsb pdb:5FJY|rcsb pdb:6EJN|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|dip:DIP-31518N psi-mi:"MI:0469"(intact) - - figure legend:1D|comment:The antibody used reacts with both KLC-1 and KLC-2 in the brain. KLC-1 is the major form of KLC in the hypothalamus and was coprecipitated by the antibody to HAP1.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2006/07/26 2014/10/16 rogid:mrrVufzrFAAiuT8yarD5JfWlRbc10090 rogid:g0zmL5gh0ehRJnJSpKFQpe7Xcps10090 intact-crc:C8FC8E8AF427EADC|rigid:crQvqnjblgblQXRkBSXI2eCG52g false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54256-2 uniprotkb:P56536 intact:EBI-994554 intact:EBI-994504 psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:kif5c_rat(display_long)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-994523|imex:IM-14428-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-994539(hap1_rat) go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|rcsb pdb:2KIN|rcsb pdb:3KIN|rgd:1308539|interpro:IPR019821|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|mint:P56536|interpro:IPR036961 psi-mi:"MI:0469"(intact) isoform-comment:Contains a phosphothreonine at position 598. - agonist:The colocalisation was observed in the presence of NGF treatment.|figure legend:2B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2006/07/26 2014/10/16 rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116 rogid:XicHwXiTTxlnHBH1NkJ0SCgSGzY10116 intact-crc:CC259D6ED4562AA6|rigid:yqwykMTZHO46BosSJKvGfu8ZRRk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P56536 uniprotkb:O35668-2 intact:EBI-994504 intact:EBI-473719|ensembl:ENSMUSP00000099413 psi-mi:kif5c_rat(display_long)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym) psi-mi:o35668-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:"MI:0416"(fluorescence microscopy) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-1025068|imex:IM-14428-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|rcsb pdb:2KIN|rcsb pdb:3KIN|rgd:1308539|interpro:IPR019821|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|mint:P56536|interpro:IPR036961 intact:EBI-473704(hap1_mouse)|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000103124(transcript) psi-mi:"MI:0469"(intact) - isoform-comment:Contains a phosphothreonine at position 598. agonist:The colocalisation was observed in the presence of NGF treatment.|figure legend:3|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2006/07/26 2014/10/16 rogid:XicHwXiTTxlnHBH1NkJ0SCgSGzY10116 rogid:+hWyU6CmJ+N5z7MooezHFcILh0010090 intact-crc:E9FD786BABCAF915|rigid:ziD6eAtlO4MfUSrTWgwEHdtCqq0 false - green fluorescent protein tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54256-2 uniprotkb:B2GV74 intact:EBI-994554 intact:EBI-978371|ensembl:ENSRNOP00000050555 psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:b2gv74_rat(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short)|uniprotkb:Klc2_predicted(gene name synonym)|uniprotkb:rCG_48462(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-994563|imex:IM-14428-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-994539(hap1_rat) ensembl:ENSRNOG00000020299(gene)|ensembl:ENSRNOT00000041238(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|reactome:R-RNO-2132295|reactome:R-RNO-5625970|reactome:R-RNO-6811434|reactome:R-RNO-983189|refseq:XP_006223670.1|refseq:XP_006223671.1|refseq:XP_006223672.1|refseq:XP_006223673.1|refseq:XP_006230996.1|refseq:XP_006230997.1|refseq:XP_006230998.1|refseq:XP_006230999.1|refseq:XP_003749090.1|refseq:XP_003749091.1|refseq:XP_003753425.1|refseq:XP_003753426.1|rgd:1307377|refseq:XP_017445775.1|refseq:XP_017459758.1|dip:DIP-59340N psi-mi:"MI:0469"(intact) isoform-comment:Contains a phosphothreonine at position 598. - figure legend:2C|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2006/07/26 2014/10/16 rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116 rogid:kVHNcKrsZtzhsauo5ts6nPaQb9w10116 intact-crc:AAB448E582E3683B|rigid:UC09u8ZirmBccQmuOplo8Rfn2kM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P54256-2 uniprotkb:P54256-1 intact:EBI-994554 intact:EBI-994549 psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:p54256-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) McGuire et al. (2006) imex:IM-14428|pubmed:16339760 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-994563|imex:IM-14428-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-994539(hap1_rat) intact:EBI-994539(hap1_rat) psi-mi:"MI:0469"(intact) isoform-comment:Contains a phosphothreonine at position 598. - figure legend:2C|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2006/07/26 2014/10/16 rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116 rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116 intact-crc:AAB448E582E3683B|rigid:UC09u8ZirmBccQmuOplo8Rfn2kM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)