#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q4AE70	uniprotkb:P15337	intact:EBI-973358|uniprotkb:Q4AE68|uniprotkb:Q4AE69|uniprotkb:Q4AE71	intact:EBI-973322|ensembl:ENSRNOP00000049369	psi-mi:carm1_rat(display_long)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym)|uniprotkb:Carm1(gene name)|psi-mi:Carm1(display_short)|uniprotkb:Prmt4(gene name synonym)	psi-mi:creb1_rat(display_long)|uniprotkb:Creb1(gene name)|psi-mi:Creb1(display_short)|uniprotkb:Creb-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krones-Herzig et al. (2006)	imex:IM-14479|pubmed:16330542	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-973418|imex:IM-14479-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006479"(protein methylation)|go:"GO:0007568"(aging)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|rcsb pdb:3B3G|rcsb pdb:3B3J|rgd:1305879|refseq:NP_001025212.1|refseq:NP_001029260.1|interpro:IPR020989|rcsb pdb:2OQB|rcsb pdb:3B3F|reactome:R-RNO-400206|reactome:R-RNO-9707564|reactome:R-RNO-9018519|interpro:IPR025799|interpro:IPR029063|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-RNO-3214858	ensembl:ENSRNOG00000013412(gene)|go:"GO:0000785"(chromatin)|ensembl:ENSRNOT00000049654(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|rcsb pdb:1KDX|reactome:R-RNO-198693|reactome:R-RNO-199920|reactome:R-RNO-375165|reactome:R-RNO-442742|reactome:R-RNO-881907|reactome:R-RNO-9031628|reactome:R-RNO-9634638|rgd:620218|refseq:NP_112279.1|refseq:NP_604392.1|refseq:XP_006245127.1|refseq:XP_006245128.1|dip:DIP-36407N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 4B|agonist:Forskolin|caution:There are four variants of Coactivator-associated arginine methyltransferase 1 protein and the specfic variant recognised by the antibody used for coimmunoprecipitaion is not stated in the text.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-h4iie)|taxid:10116(Rat hepatoma cell line H4IIE)	-	2006/07/19	2020/10/21	rogid:2qOERLGio0khmG+IkHfZuNdc+O810116	rogid:CwTrBzH0LR4Qlw71kKY1BmzXcuk10116	intact-crc:002707C1E10BE81E|rigid:YqRVIlLrJNDyEmn99r9yNMcjRH0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)