#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13050	uniprotkb:P04003	intact:EBI-978341	intact:EBI-978348|ensembl:ENSP00000356037|uniprotkb:Q5VVQ8	psi-mi:arp4_strpy(display_long)|uniprotkb:arp4(gene name)|psi-mi:arp4(display_short)	psi-mi:c4bpa_human(display_long)|uniprotkb:Proline-rich protein(gene name synonym)|uniprotkb:C4BPA(gene name)|psi-mi:C4BPA(display_short)|uniprotkb:C4BP(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Jenkins et al. (2006)	imex:IM-14429|pubmed:16330538	taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-978355|imex:IM-14429-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|interpro:IPR005877(YSIRK Gram-positive signal peptide)|interpro:IPR019950|interpro:IPR003345(M protein repeat)|interpro:IPR019931	ensembl:ENSG00000123838(gene)|ensembl:ENST00000367070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|rcsb pdb:2A55|rcsb pdb:4B0F|rcsb pdb:5HYP|rcsb pdb:5HYT|rcsb pdb:5HYU|rcsb pdb:5HZP|rcsb pdb:5I0Q|reactome:R-HSA-977606|refseq:NP_000706.1|refseq:XP_005273308.1|refseq:XP_005273309.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1A|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/27	2014/10/16	rogid:k/bn+U+qgTKG8umFVeV2s9f1ZaU1314	rogid:S0F99wuDTalS4UCuYGWbiCgWlO09606	intact-crc:49B40E2700F3220C|rigid:9KcGrpn6AACB/+g+KhHoC6DZOyo	false	-	sufficient binding region:1-62	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P04003	uniprotkb:P13050	intact:EBI-978348|ensembl:ENSP00000356037|uniprotkb:Q5VVQ8	intact:EBI-978341	psi-mi:c4bpa_human(display_long)|uniprotkb:Proline-rich protein(gene name synonym)|uniprotkb:C4BPA(gene name)|psi-mi:C4BPA(display_short)|uniprotkb:C4BP(gene name synonym)	psi-mi:arp4_strpy(display_long)|uniprotkb:arp4(gene name)|psi-mi:arp4(display_short)	psi-mi:"MI:0440"(saturation binding)	Jenkins et al. (2006)	imex:IM-14429|pubmed:16330538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-978362|imex:IM-14429-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123838(gene)|ensembl:ENST00000367070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|rcsb pdb:2A55|rcsb pdb:4B0F|rcsb pdb:5HYP|rcsb pdb:5HYT|rcsb pdb:5HYU|rcsb pdb:5HZP|rcsb pdb:5I0Q|reactome:R-HSA-977606|refseq:NP_000706.1|refseq:XP_005273308.1|refseq:XP_005273309.1	go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|interpro:IPR005877(YSIRK Gram-positive signal peptide)|interpro:IPR019950|interpro:IPR003345(M protein repeat)|interpro:IPR019931	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1A|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/27	2014/10/16	rogid:S0F99wuDTalS4UCuYGWbiCgWlO09606	rogid:k/bn+U+qgTKG8umFVeV2s9f1ZaU1314	intact-crc:F29C60FD0FDE5795|rigid:9KcGrpn6AACB/+g+KhHoC6DZOyo	false	sufficient binding region:63-124	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P04003	uniprotkb:P13050	intact:EBI-978348|ensembl:ENSP00000356037|uniprotkb:Q5VVQ8	intact:EBI-978341	psi-mi:c4bpa_human(display_long)|uniprotkb:Proline-rich protein(gene name synonym)|uniprotkb:C4BPA(gene name)|psi-mi:C4BPA(display_short)|uniprotkb:C4BP(gene name synonym)	psi-mi:arp4_strpy(display_long)|uniprotkb:arp4(gene name)|psi-mi:arp4(display_short)	psi-mi:"MI:0440"(saturation binding)	Jenkins et al. (2006)	imex:IM-14429|pubmed:16330538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-978395|imex:IM-14429-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123838(gene)|ensembl:ENST00000367070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|rcsb pdb:2A55|rcsb pdb:4B0F|rcsb pdb:5HYP|rcsb pdb:5HYT|rcsb pdb:5HYU|rcsb pdb:5HZP|rcsb pdb:5I0Q|reactome:R-HSA-977606|refseq:NP_000706.1|refseq:XP_005273308.1|refseq:XP_005273309.1	go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|interpro:IPR005877(YSIRK Gram-positive signal peptide)|interpro:IPR019950|interpro:IPR003345(M protein repeat)|interpro:IPR019931	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1B|comment:Insertion of two alanine residues between Lysine 188 and Isoleucine 189 resulted in abolished interaction between the two proteins.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/27	2014/10/16	rogid:S0F99wuDTalS4UCuYGWbiCgWlO09606	rogid:k/bn+U+qgTKG8umFVeV2s9f1ZaU1314	intact-crc:EDF8ADBD4B3C8A83|rigid:9KcGrpn6AACB/+g+KhHoC6DZOyo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P04003	uniprotkb:P13050	intact:EBI-978348|ensembl:ENSP00000356037|uniprotkb:Q5VVQ8	intact:EBI-978341	psi-mi:c4bpa_human(display_long)|uniprotkb:Proline-rich protein(gene name synonym)|uniprotkb:C4BPA(gene name)|psi-mi:C4BPA(display_short)|uniprotkb:C4BP(gene name synonym)	psi-mi:arp4_strpy(display_long)|uniprotkb:arp4(gene name)|psi-mi:arp4(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Jenkins et al. (2006)	imex:IM-14429|pubmed:16330538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-978429|imex:IM-14429-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123838(gene)|ensembl:ENST00000367070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|rcsb pdb:2A55|rcsb pdb:4B0F|rcsb pdb:5HYP|rcsb pdb:5HYT|rcsb pdb:5HYU|rcsb pdb:5HZP|rcsb pdb:5I0Q|reactome:R-HSA-977606|refseq:NP_000706.1|refseq:XP_005273308.1|refseq:XP_005273309.1	go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|interpro:IPR005877(YSIRK Gram-positive signal peptide)|interpro:IPR019950|interpro:IPR003345(M protein repeat)|interpro:IPR019931	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1C|comment:A dimer of the APR4 protein was created as previous studies had shown that dimerization strongly enhanced C4BP binding. The APR4 protein used in this stidy also had a C-terminal Cys added.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/27	2014/10/16	rogid:S0F99wuDTalS4UCuYGWbiCgWlO09606	rogid:k/bn+U+qgTKG8umFVeV2s9f1ZaU1314	intact-crc:3C25259C4FD0DC82|rigid:9KcGrpn6AACB/+g+KhHoC6DZOyo	false	his tag:c-c|sufficient binding region:1-124	sufficient binding region:1-45	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04003	uniprotkb:P13050	intact:EBI-978348|ensembl:ENSP00000356037|uniprotkb:Q5VVQ8	intact:EBI-978341	psi-mi:c4bpa_human(display_long)|uniprotkb:Proline-rich protein(gene name synonym)|uniprotkb:C4BPA(gene name)|psi-mi:C4BPA(display_short)|uniprotkb:C4BP(gene name synonym)	psi-mi:arp4_strpy(display_long)|uniprotkb:arp4(gene name)|psi-mi:arp4(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Jenkins et al. (2006)	imex:IM-14429|pubmed:16330538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-978544|imex:IM-14429-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123838(gene)|ensembl:ENST00000367070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|rcsb pdb:2A55|rcsb pdb:4B0F|rcsb pdb:5HYP|rcsb pdb:5HYT|rcsb pdb:5HYU|rcsb pdb:5HZP|rcsb pdb:5I0Q|reactome:R-HSA-977606|refseq:NP_000706.1|refseq:XP_005273308.1|refseq:XP_005273309.1	go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|interpro:IPR005877(YSIRK Gram-positive signal peptide)|interpro:IPR019950|interpro:IPR003345(M protein repeat)|interpro:IPR019931	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 4 and Figure 5|comment:The APR4 protein was present as a dimer.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/27	2014/10/16	rogid:S0F99wuDTalS4UCuYGWbiCgWlO09606	rogid:k/bn+U+qgTKG8umFVeV2s9f1ZaU1314	intact-crc:5B4E11CBF8B499F2|rigid:9KcGrpn6AACB/+g+KhHoC6DZOyo	false	sufficient binding region:49-172	sufficient binding region:1-45	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)