#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43320	uniprotkb:P43320	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2006)	imex:IM-14481|pubmed:16319073	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-974094|imex:IM-14481-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 3|caution:The authors used N-terminal and C-terminal regions in separate constructs to analyse dimer formation using a mammalian two hybrid assay. However the coordiates of the constructs are not given and the results are presented as if a full length beta B2 crysatllin protein was analysed.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/20	2014/10/16	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:2733609C579A1288|rigid:5PhS6Y0gOEcYqpgSlMvbhvck7io	false	mutation decreasing interaction:54-54|mutation decreasing interaction:60-60|mutation decreasing interaction:73-73|mutation decreasing interaction:97-97|mutation decreasing interaction:109-109|mutation decreasing interaction:125-125|mutation decreasing interaction:144-144|mutation decreasing interaction:152-152|mutation decreasing interaction:166-166|mutation decreasing interaction:187-187	mutation decreasing interaction:187-187|mutation decreasing interaction:54-54|mutation decreasing interaction:60-60|mutation decreasing interaction:73-73|mutation decreasing interaction:97-97|mutation decreasing interaction:109-109|mutation decreasing interaction:125-125|mutation decreasing interaction:144-144|mutation decreasing interaction:166-166	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43320	uniprotkb:P43320	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2006)	imex:IM-14481|pubmed:16319073	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-974164|imex:IM-14481-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2|caution:The authors used N-terminal and C-terminal regions in separate constructs to analyse dimer formation using a mammalian two hybrid assay. However the coordiates of the constructs are not given and the results are presented as if a full length beta B2 crysatllin protein was analysed.|caution:It is not clear form the text if bait or prey protein was muated in the analysis. The data is presented as if the bait protein was mutated.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/20	2014/10/16	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:3D8AA764F0A610F5|rigid:5PhS6Y0gOEcYqpgSlMvbhvck7io	false	-	mutation decreasing interaction:54-54|mutation decreasing interaction:60-60|mutation decreasing interaction:73-73|mutation decreasing interaction:97-97|mutation decreasing interaction:109-109|mutation decreasing interaction:125-125|mutation decreasing interaction:144-144|mutation decreasing interaction:152-152|mutation decreasing interaction:166-166|mutation decreasing interaction:187-187	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43320	uniprotkb:P43320	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2006)	imex:IM-14481|pubmed:16319073	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-974190|imex:IM-14481-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1|caution:The authors used N-terminal and C-terminal regions in separate constructs to analyse dimer formation using a mammalian two hybrid assay. However the coordiates of the constructs are not given and the results are presented as if a full length beta B2 crysatllin protein was analysed.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/20	2014/10/16	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:A41C5C6EB7419130|rigid:5PhS6Y0gOEcYqpgSlMvbhvck7io	false	mutation decreasing interaction:54-54|mutation decreasing interaction:60-60|mutation decreasing interaction:73-73|mutation decreasing interaction:97-97|mutation decreasing interaction:109-109|mutation decreasing interaction:125-125|mutation decreasing interaction:144-144|mutation decreasing interaction:166-166|mutation decreasing interaction:187-187	mutation decreasing interaction:54-54|mutation decreasing interaction:60-60|mutation decreasing interaction:73-73|mutation decreasing interaction:97-97|mutation decreasing interaction:109-109|mutation decreasing interaction:125-125|mutation decreasing interaction:144-144|mutation decreasing interaction:152-152|mutation decreasing interaction:166-166|mutation decreasing interaction:187-187	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43320	uniprotkb:P43320	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Liu et al. (2006)	imex:IM-14481|pubmed:16319073	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-974238|imex:IM-14481-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 5|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/20	2014/10/16	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:C26ADF002D2A1196|rigid:5PhS6Y0gOEcYqpgSlMvbhvck7io	false	mutation decreasing interaction:144-144|mutation decreasing interaction:60-60	mutation decreasing interaction:60-60|mutation decreasing interaction:144-144	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)