#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27824	uniprotkb:Q9HBA0-2	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	intact:EBI-961973|ensembl:ENSP00000442738	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:q9hba0-2(display_long)|uniprotkb:OTRPC4beta(isoform synonym)|uniprotkb:B(isoform synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-961983|imex:IM-14538-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	ensembl:ENSG00000111199(gene)|ensembl:ENST00000537083(transcript)|intact:EBI-962786(trpv4_human)	go:"GO:0005783"(endoplasmic reticulum)	-	isoform-comment:Lacks channel activity, due to impaired oligomerization and intracellular retention.	figure legend:3C|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/04	2014/10/16	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	rogid:IqYA89Qgv3bO/kx05tsKREkA9E89606	intact-crc:244CF1BBA7FE6C10|rigid:n7qUZZaJAxGaoh81h0OvOreSmaM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27824	uniprotkb:Q9HBA0-4	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	intact:EBI-1514303|ensembl:ENSP00000442167	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:q9hba0-4(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:C(isoform synonym)	psi-mi:"MI:0663"(confocal microscopy)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962728|imex:IM-14538-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	ensembl:ENSG00000111199(gene)|ensembl:ENST00000541794(transcript)|intact:EBI-962786(isoform-parent)	go:"GO:0005783"(endoplasmic reticulum)	-	isoform-comment:Lacks channel activity, due to impaired oligomerization and intracellular retention.	figure legend:3C|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/04	2014/12/19	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	rogid:4j2cj7aOMVaUKIy17AQkl1DrqO89606	intact-crc:BACBD85F4AE2F704|rigid:eouRGVMTdQZ5KLByCiXeHQu2rL8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9HBA0	uniprotkb:P27824	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962747|imex:IM-14538-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:3C|isoform-comment:Splice isoform E|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/04	2014/10/16	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	intact-crc:456835CDC379D21E|rigid:JX55Or6EnaGf4Hwlccg1Mc3x5v8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9HBA0-1	uniprotkb:Q9HBA0-1	intact:EBI-961969|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135	intact:EBI-961969|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135	psi-mi:q9hba0-1(display_long)|uniprotkb:A(isoform synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)	psi-mi:q9hba0-1(display_long)|uniprotkb:A(isoform synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962768|imex:IM-14538-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|intact:EBI-962786(isoform-parent)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|intact:EBI-962786(isoform-parent)	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:5|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/04	2014/10/16	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	intact-crc:451ECEF24004E394|rigid:t+zc8DeXYUbbH52cMDmia8bLea0	false	tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HBA0-5	uniprotkb:Q9HBA0-5	intact:EBI-10048039|ensembl:ENSP00000444336	intact:EBI-10048039|ensembl:ENSP00000444336	psi-mi:q9hba0-5(display_long)|uniprotkb:D(isoform synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:q9hba0-5(display_long)|uniprotkb:D(isoform synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962803|imex:IM-14538-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000536838(transcript)|intact:EBI-962786(isoform-parent)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000536838(transcript)|intact:EBI-962786(isoform-parent)	go:"GO:0042803"(protein homodimerization activity)	isoform-comment:Forms active ion channels.	isoform-comment:Forms active ion channels.	figure legend:5|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/04	2014/12/19	rogid:ETifmJ/gSMgKviRdC7l/CS20B7w9606	rogid:ETifmJ/gSMgKviRdC7l/CS20B7w9606	intact-crc:DAD45C03F4BC3EBB|rigid:Sa4OIpeDmXKGQsNYk4xPWjNKOQs	false	tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HBA0-1	uniprotkb:Q9HBA0-5	intact:EBI-961969|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135	intact:EBI-10048039|ensembl:ENSP00000444336	psi-mi:q9hba0-1(display_long)|uniprotkb:A(isoform synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)	psi-mi:q9hba0-5(display_long)|uniprotkb:D(isoform synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962841|imex:IM-14538-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|intact:EBI-962786(isoform-parent)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000536838(transcript)|intact:EBI-962786(isoform-parent)	go:"GO:0051290"(protein heterotetramerization)	-	isoform-comment:Forms active ion channels.	figure legend:6B|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/07/04	2014/12/19	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	rogid:ETifmJ/gSMgKviRdC7l/CS20B7w9606	intact-crc:FAD95B91AD09AF4E|rigid:5drCi8YeTTfUtCrmWGN3/q6uaBA	false	yellow fluorescent protein tag:?-?	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HBA0-5	uniprotkb:Q9HBA0-1	intact:EBI-10048039|ensembl:ENSP00000444336	intact:EBI-961969|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135	psi-mi:q9hba0-5(display_long)|uniprotkb:D(isoform synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:q9hba0-1(display_long)|uniprotkb:A(isoform synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962828|imex:IM-14538-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000536838(transcript)|intact:EBI-962786(isoform-parent)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|intact:EBI-962786(isoform-parent)	go:"GO:0051290"(protein heterotetramerization)|go:"GO:0005886"(plasma membrane)	isoform-comment:Forms active ion channels.	-	figure legend:6A|isoform-comment:Splice isoform D colocalises withQ9HBA0|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/04	2014/12/19	rogid:ETifmJ/gSMgKviRdC7l/CS20B7w9606	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	intact-crc:7D69D8FEF08EA446|rigid:5drCi8YeTTfUtCrmWGN3/q6uaBA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9HBA0-5	uniprotkb:Q9HBA0-1	intact:EBI-10048039|ensembl:ENSP00000444336	intact:EBI-961969|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135	psi-mi:q9hba0-5(display_long)|uniprotkb:D(isoform synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:q9hba0-1(display_long)|uniprotkb:A(isoform synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arniges et al. (2006)	imex:IM-14538|pubmed:16293632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962862|imex:IM-14538-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000536838(transcript)|intact:EBI-962786(isoform-parent)	ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|intact:EBI-962786(isoform-parent)	go:"GO:0051290"(protein heterotetramerization)	isoform-comment:Forms active ion channels.	-	figure legend:6C|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/04	2014/12/19	rogid:ETifmJ/gSMgKviRdC7l/CS20B7w9606	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	intact-crc:74C9B2C1F9885D8A|rigid:5drCi8YeTTfUtCrmWGN3/q6uaBA	false	yellow fluorescent protein tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)