#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13261	uniprotkb:P40933	intact:EBI-980354|uniprotkb:Q5JVA2|uniprotkb:Q6B0J2|uniprotkb:Q5JVA4|uniprotkb:Q7LDR4|ensembl:ENSP00000369312|uniprotkb:Q7Z609|uniprotkb:B4E2C2|uniprotkb:Q5JVA1|uniprotkb:Q3B769	intact:EBI-980274|uniprotkb:O00440|uniprotkb:O43512|uniprotkb:Q495Z8|uniprotkb:Q93058|uniprotkb:Q9UBA3|ensembl:ENSP00000296545|ensembl:ENSP00000323505|ensembl:ENSP00000435462|uniprotkb:D3DNZ2|intact:EBI-3910781|uniprotkb:Q6FGX7	psi-mi:i15ra_human(display_long)|uniprotkb:IL15RA(gene name)|psi-mi:IL15RA(display_short)	psi-mi:il15_human(display_long)|uniprotkb:IL15(gene name)|psi-mi:IL15(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortier et al. (2006)	imex:IM-14438|pubmed:16284400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-980314|imex:IM-14438-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134470(gene)|ensembl:ENST00000379977(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR042372|rcsb pdb:2ERS|rcsb pdb:2Z3Q|rcsb pdb:2Z3R|rcsb pdb:4GS7|reactome:R-HSA-8983432|refseq:NP_001243694.1|refseq:NP_001230468.1|refseq:NP_002180.1|refseq:NP_751950.2	ensembl:ENSG00000164136(gene)|ensembl:ENST00000296545(transcript)|ensembl:ENST00000320650(transcript)|ensembl:ENST00000529613(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001866"(NK T cell proliferation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0016607"(nuclear speck)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045062"(extrathymic T cell selection)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048469"(cell maturation)|go:"GO:0007165"(signal transduction)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0048535"(lymph node development)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904100"(positive regulation of protein O-linked glycosylation)|interpro:IPR003443(Interleukin 15)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020439|interpro:IPR020466|rcsb pdb:2XQB|rcsb pdb:2Z3Q|rcsb pdb:2Z3R|rcsb pdb:4GS7|reactome:R-HSA-8983432|refseq:NP_000576.1|refseq:NP_751915.1|dip:DIP-3046N	psi-mi:"MI:0469"(intact)	-	-	comment:The recombinant IL-15 from Peprotech Inc. corresponds to residues 48-162 of the Uniprot entry except at position 48 there is met substituted for ala.|figure legend:1 A|kinetics:kon =3.7 E5 per M per S; koff =1.4 E-5 per s; Kd=3.8 E-11 M|comment:These results indicate that the sushi domain is responsible for most of the binding affinity of IL-15 but that it does not fully reconstitute the high affinity binding displayed by the full-length extracellular domain.|comment:The IL-15Ralpha proteins are annotated to begin at residue 31 as the Uniprot annotation indicates residues 1-30 constitute a signal peptide, which should be removed when expressed in CHO cells.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/01	2014/10/16	rogid:lwiZ6GPZs2SMjWuWJ5NoqgONVAE9606	rogid:Hjoh3ZfpRU0P+xGk7mRhRJJrqkg9606	intact-crc:7E2823D26C09A7F5|rigid:+5ydGYNd/qLxnn+dC4BmsMPX2hM	false	binding-associated region:31..31-219|fusion protein:c-c	sufficient binding region:48-162	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40933	uniprotkb:Q13261	intact:EBI-980274|uniprotkb:O00440|uniprotkb:O43512|uniprotkb:Q495Z8|uniprotkb:Q93058|uniprotkb:Q9UBA3|ensembl:ENSP00000296545|ensembl:ENSP00000323505|ensembl:ENSP00000435462|uniprotkb:D3DNZ2|intact:EBI-3910781|uniprotkb:Q6FGX7	intact:EBI-980354|uniprotkb:Q5JVA2|uniprotkb:Q6B0J2|uniprotkb:Q5JVA4|uniprotkb:Q7LDR4|ensembl:ENSP00000369312|uniprotkb:Q7Z609|uniprotkb:B4E2C2|uniprotkb:Q5JVA1|uniprotkb:Q3B769	psi-mi:il15_human(display_long)|uniprotkb:IL15(gene name)|psi-mi:IL15(display_short)	psi-mi:i15ra_human(display_long)|uniprotkb:IL15RA(gene name)|psi-mi:IL15RA(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortier et al. (2006)	imex:IM-14438|pubmed:16284400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983582|imex:IM-14438-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164136(gene)|ensembl:ENST00000296545(transcript)|ensembl:ENST00000320650(transcript)|ensembl:ENST00000529613(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001866"(NK T cell proliferation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0016607"(nuclear speck)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045062"(extrathymic T cell selection)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048469"(cell maturation)|go:"GO:0007165"(signal transduction)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0048535"(lymph node development)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904100"(positive regulation of protein O-linked glycosylation)|interpro:IPR003443(Interleukin 15)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020439|interpro:IPR020466|rcsb pdb:2XQB|rcsb pdb:2Z3Q|rcsb pdb:2Z3R|rcsb pdb:4GS7|reactome:R-HSA-8983432|refseq:NP_000576.1|refseq:NP_751915.1|dip:DIP-3046N	ensembl:ENSG00000134470(gene)|ensembl:ENST00000379977(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR042372|rcsb pdb:2ERS|rcsb pdb:2Z3Q|rcsb pdb:2Z3R|rcsb pdb:4GS7|reactome:R-HSA-8983432|refseq:NP_001243694.1|refseq:NP_001230468.1|refseq:NP_002180.1|refseq:NP_751950.2	psi-mi:"MI:0469"(intact)	-	-	comment:The recombinant IL-15 from Peprotech Inc. corresponds to residues 48-162 of the Uniprot entry except at position 48 there is met substituted for ala.|figure legend:1 B|kinetics:kon=3.1 E5 per M per s; koff =1.3 E-4 per s; Kd =4.2 E-10 M|comment:These results indicate that the sushi domain is responsible for most of the binding affinity of IL-15 but that it does not fully reconstitute the high affinity binding displayed by the full-length extracellular domain.|comment:The IL-15Ralpha proteins are annotated to begin at residue 31 as the Uniprot annotation indicates residues 1-30 constitute a signal peptide, which should be removed when expressed in CHO cells.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/01	2014/10/16	rogid:Hjoh3ZfpRU0P+xGk7mRhRJJrqkg9606	rogid:lwiZ6GPZs2SMjWuWJ5NoqgONVAE9606	intact-crc:635E99E56C04F30F|rigid:+5ydGYNd/qLxnn+dC4BmsMPX2hM	false	sufficient binding region:48-162	fusion protein:c-c|binding-associated region:31..31-96..96	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40933	uniprotkb:Q13261	intact:EBI-980274|uniprotkb:O00440|uniprotkb:O43512|uniprotkb:Q495Z8|uniprotkb:Q93058|uniprotkb:Q9UBA3|ensembl:ENSP00000296545|ensembl:ENSP00000323505|ensembl:ENSP00000435462|uniprotkb:D3DNZ2|intact:EBI-3910781|uniprotkb:Q6FGX7	intact:EBI-980354|uniprotkb:Q5JVA2|uniprotkb:Q6B0J2|uniprotkb:Q5JVA4|uniprotkb:Q7LDR4|ensembl:ENSP00000369312|uniprotkb:Q7Z609|uniprotkb:B4E2C2|uniprotkb:Q5JVA1|uniprotkb:Q3B769	psi-mi:il15_human(display_long)|uniprotkb:IL15(gene name)|psi-mi:IL15(display_short)	psi-mi:i15ra_human(display_long)|uniprotkb:IL15RA(gene name)|psi-mi:IL15RA(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortier et al. (2006)	imex:IM-14438|pubmed:16284400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983600|imex:IM-14438-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164136(gene)|ensembl:ENST00000296545(transcript)|ensembl:ENST00000320650(transcript)|ensembl:ENST00000529613(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001866"(NK T cell proliferation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0016607"(nuclear speck)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045062"(extrathymic T cell selection)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048469"(cell maturation)|go:"GO:0007165"(signal transduction)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0048535"(lymph node development)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904100"(positive regulation of protein O-linked glycosylation)|interpro:IPR003443(Interleukin 15)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020439|interpro:IPR020466|rcsb pdb:2XQB|rcsb pdb:2Z3Q|rcsb pdb:2Z3R|rcsb pdb:4GS7|reactome:R-HSA-8983432|refseq:NP_000576.1|refseq:NP_751915.1|dip:DIP-3046N	ensembl:ENSG00000134470(gene)|ensembl:ENST00000379977(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR042372|rcsb pdb:2ERS|rcsb pdb:2Z3Q|rcsb pdb:2Z3R|rcsb pdb:4GS7|reactome:R-HSA-8983432|refseq:NP_001243694.1|refseq:NP_001230468.1|refseq:NP_002180.1|refseq:NP_751950.2	psi-mi:"MI:0469"(intact)	-	-	comment:The recombinant IL-15 from Peprotech Inc. corresponds to residues 48-162 of the Uniprot entry except at position 48 there is met substituted for ala.|figure legend:1 C|kinetics:kon =2.5 E5 per M per s ; koff=3.8 E-4 per s; Kd= 1.5 E-9 M|caution:"It is not clear if the signal peptide (Uniprot annotation indicates it is residues 1-30 of the sequence) is removed from the sIL-15Ralpha-sushi expressed in E. coli (referred to in the annotation topic kinetics). Nor is it clear if this protein is fused to human Il-2, but it seems not as IL-2 is not included in the name of the construct."|comment:These results indicate that the sushi domain is responsible for most of the binding affinity of IL-15 but that it does not fully reconstitute the high affinity binding displayed by the full-length extracellular domain.|comment:The IL-15Ralpha proteins are annotated to begin at residue 31 as the Uniprot annotation indicates residues 1-30 constitute a signal peptide, which should be removed when expressed in CHO cells.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/01	2014/10/16	rogid:Hjoh3ZfpRU0P+xGk7mRhRJJrqkg9606	rogid:lwiZ6GPZs2SMjWuWJ5NoqgONVAE9606	intact-crc:635DB81E5B6608F5|rigid:+5ydGYNd/qLxnn+dC4BmsMPX2hM	false	sufficient binding region:48-162	binding-associated region:31..31-96..96	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)