#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P54274-2	uniprotkb:Q9UKT5-1	intact:EBI-711018|ensembl:ENSP00000276602	intact:EBI-960421|ensembl:ENSP00000281623	psi-mi:p54274-2(display_long)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRBF1(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:Pin2(isoform synonym)	psi-mi:q9ukt5-1(display_long)|uniprotkb:FBXO4(gene name)|psi-mi:FBXO4(display_short)|uniprotkb:FBX4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2006)	imex:IM-14430|pubmed:16275645	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-960430|imex:IM-14430-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-710997(terf1_human)|ensembl:ENSG00000147601(gene)|ensembl:ENST00000276602(transcript)|uniprotkb:P54274-2(isoform-parent)	ensembl:ENSG00000151876(gene)|ensembl:ENST00000281623(transcript)|intact:EBI-960409(fbx4_human)	psi-mi:"MI:0469"(intact)	-	-	figure legend:1A|dataset:Cancer - Interactions investigated in the context of cancer|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/29	2014/10/16	rogid:hX5owgLwr/JCK2JJ+khossLxtYA9606	rogid:tCM4jv7DF/Wujdm2j3i95oknxaE9606	intact-crc:6764D046FDCE1211|rigid:7S0jZQi/8gP5xS9b54psL9SVZpM	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UKT5-1	uniprotkb:P54274	intact:EBI-960421|ensembl:ENSP00000281623	intact:EBI-710997|uniprotkb:A7XP29|uniprotkb:Q15553|uniprotkb:Q93029|ensembl:ENSP00000276603|uniprotkb:Q8NHT6	psi-mi:q9ukt5-1(display_long)|uniprotkb:FBXO4(gene name)|psi-mi:FBXO4(display_short)|uniprotkb:FBX4(gene name synonym)	psi-mi:terf1_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:TRBF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2006)	imex:IM-14430|pubmed:16275645	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-960438|imex:IM-14430-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000151876(gene)|ensembl:ENST00000281623(transcript)|intact:EBI-960409(fbx4_human)	refseq:NP_003209.2|refseq:NP_059523.2|ensembl:ENSG00000147601(gene)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|ensembl:ENST00000276603(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P54274|rcsb pdb:1BA5|rcsb pdb:1H6O|rcsb pdb:1ITY|rcsb pdb:1IV6|rcsb pdb:1W0T|rcsb pdb:3BQO|rcsb pdb:3L82|rcsb pdb:5HKP|rcsb pdb:5WIR|rcsb pdb:5XUP|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0090656"(t-circle formation)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1904914"(negative regulation of establishment of protein-containing complex localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|dip:DIP-29412N	psi-mi:"MI:0469"(intact)	-	-	figure legend:1B|dataset:Cancer - Interactions investigated in the context of cancer|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/29	2014/10/16	rogid:tCM4jv7DF/Wujdm2j3i95oknxaE9606	rogid:3Tjmp8hqEhLBIQqxxWHntpL4hz49606	intact-crc:19DF971A017885A5|rigid:Rdrswd/rJvmpvDVbl9pIlma+iNw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UKT5-1	uniprotkb:P54274-2	intact:EBI-960421|ensembl:ENSP00000281623	intact:EBI-711018|ensembl:ENSP00000276602	psi-mi:q9ukt5-1(display_long)|uniprotkb:FBXO4(gene name)|psi-mi:FBXO4(display_short)|uniprotkb:FBX4(gene name synonym)	psi-mi:p54274-2(display_long)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRBF1(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:Pin2(isoform synonym)	psi-mi:"MI:0096"(pull down)	Lee et al. (2006)	imex:IM-14430|pubmed:16275645	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-960456|imex:IM-14430-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000151876(gene)|ensembl:ENST00000281623(transcript)|intact:EBI-960409(fbx4_human)	intact:EBI-710997(terf1_human)|ensembl:ENSG00000147601(gene)|ensembl:ENST00000276602(transcript)|uniprotkb:P54274-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	-	figure legend:1D|dataset:Cancer - Interactions investigated in the context of cancer|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:tCM4jv7DF/Wujdm2j3i95oknxaE9606	rogid:hX5owgLwr/JCK2JJ+khossLxtYA9606	intact-crc:7E1162E318F40AB1|rigid:7S0jZQi/8gP5xS9b54psL9SVZpM	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKT5-1	uniprotkb:P54274-1	intact:EBI-960421|ensembl:ENSP00000281623	intact:EBI-711014|ensembl:ENSP00000276603	psi-mi:q9ukt5-1(display_long)|uniprotkb:FBXO4(gene name)|psi-mi:FBXO4(display_short)|uniprotkb:FBX4(gene name synonym)	psi-mi:p54274-1(display_long)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRBF1(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:TRF1(isoform synonym)	psi-mi:"MI:0096"(pull down)	Lee et al. (2006)	imex:IM-14430|pubmed:16275645	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-960464|imex:IM-14430-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000151876(gene)|ensembl:ENST00000281623(transcript)|intact:EBI-960409(fbx4_human)	intact:EBI-710997(terf1_human)|ensembl:ENSG00000147601(gene)|ensembl:ENST00000276603(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:1D|dataset:Cancer - Interactions investigated in the context of cancer|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:tCM4jv7DF/Wujdm2j3i95oknxaE9606	rogid:3Tjmp8hqEhLBIQqxxWHntpL4hz49606	intact-crc:9213AC2FC8F4879F|rigid:Rdrswd/rJvmpvDVbl9pIlma+iNw	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKT5-1	uniprotkb:P54274-2	intact:EBI-960421|ensembl:ENSP00000281623	intact:EBI-711018|ensembl:ENSP00000276602	psi-mi:q9ukt5-1(display_long)|uniprotkb:FBXO4(gene name)|psi-mi:FBXO4(display_short)|uniprotkb:FBX4(gene name synonym)	psi-mi:p54274-2(display_long)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRBF1(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:Pin2(isoform synonym)	psi-mi:"MI:0096"(pull down)	Lee et al. (2006)	imex:IM-14430|pubmed:16275645	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-960472|imex:IM-14430-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000151876(gene)|ensembl:ENST00000281623(transcript)|intact:EBI-960409(fbx4_human)	intact:EBI-710997(terf1_human)|ensembl:ENSG00000147601(gene)|ensembl:ENST00000276602(transcript)|uniprotkb:P54274-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	-	figure legend:1E and 2B and D|dataset:Cancer - Interactions investigated in the context of cancer|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/29	2014/10/16	rogid:tCM4jv7DF/Wujdm2j3i95oknxaE9606	rogid:hX5owgLwr/JCK2JJ+khossLxtYA9606	intact-crc:A531F0B39E428237|rigid:7S0jZQi/8gP5xS9b54psL9SVZpM	false	35s radiolabel:?-?|necessary binding region:172-306	glutathione s tranferase tag:?-?|necessary binding region:48-155	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54274	uniprotkb:Q9UKT5-1	intact:EBI-710997|uniprotkb:A7XP29|uniprotkb:Q15553|uniprotkb:Q93029|ensembl:ENSP00000276603|uniprotkb:Q8NHT6	intact:EBI-960421|ensembl:ENSP00000281623	psi-mi:terf1_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:TRBF1(gene name synonym)	psi-mi:q9ukt5-1(display_long)|uniprotkb:FBXO4(gene name)|psi-mi:FBXO4(display_short)|uniprotkb:FBX4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2006)	imex:IM-14430|pubmed:16275645	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-960445|imex:IM-14430-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003209.2|refseq:NP_059523.2|ensembl:ENSG00000147601(gene)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|ensembl:ENST00000276603(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P54274|rcsb pdb:1BA5|rcsb pdb:1H6O|rcsb pdb:1ITY|rcsb pdb:1IV6|rcsb pdb:1W0T|rcsb pdb:3BQO|rcsb pdb:3L82|rcsb pdb:5HKP|rcsb pdb:5WIR|rcsb pdb:5XUP|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0090656"(t-circle formation)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1904914"(negative regulation of establishment of protein-containing complex localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|dip:DIP-29412N	ensembl:ENSG00000151876(gene)|ensembl:ENST00000281623(transcript)|intact:EBI-960409(fbx4_human)	psi-mi:"MI:0469"(intact)	-	-	figure legend:1C|dataset:Cancer - Interactions investigated in the context of cancer|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/29	2014/10/16	rogid:3Tjmp8hqEhLBIQqxxWHntpL4hz49606	rogid:tCM4jv7DF/Wujdm2j3i95oknxaE9606	intact-crc:11837AFA17194201|rigid:Rdrswd/rJvmpvDVbl9pIlma+iNw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)