#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05121	uniprotkb:P02763	intact:EBI-953978|ensembl:ENSP00000223095|uniprotkb:B7Z4S0|uniprotkb:F8WD53	intact:EBI-976767|uniprotkb:Q8TC16|uniprotkb:B7ZKQ5|uniprotkb:Q5T539|ensembl:ENSP00000259396|uniprotkb:Q5U067	psi-mi:pai1_human(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:SERPINE1(gene name)|psi-mi:SERPINE1(display_short)|uniprotkb:PAI1(gene name synonym)|uniprotkb:PLANH1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:a1ag1_human(display_long)|uniprotkb:Orosomucoid-1(gene name synonym)|uniprotkb:ORM1(gene name)|psi-mi:ORM1(display_short)|uniprotkb:AGP1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Boncela et al. (2006)	imex:IM-14405|pubmed:16272158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-976782|imex:IM-14405-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106366(gene)|ensembl:ENST00000223095(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1A7C|rcsb pdb:1B3K|interpro:IPR023795|rcsb pdb:1C5G|rcsb pdb:1DB2|rcsb pdb:1DVM|rcsb pdb:1DVN|rcsb pdb:1LJ5|rcsb pdb:1OC0|rcsb pdb:3CVM|rcsb pdb:3EOX|rcsb pdb:3PB1|rcsb pdb:3Q02|rcsb pdb:3Q03|rcsb pdb:3R4L|rcsb pdb:3UT3|rcsb pdb:4AQH|rcsb pdb:4G8O|rcsb pdb:4G8R|rcsb pdb:4IC0|rcsb pdb:5BRR|rcsb pdb:5ZLZ|rcsb pdb:6GWN|rcsb pdb:6GWP|rcsb pdb:6GWQ|rcsb pdb:6I8S|rcsb pdb:6ZRV|rcsb pdb:7AQF|rcsb pdb:7AQG|rcsb pdb:9PAI|reactome:R-HSA-114608|reactome:R-HSA-1368108|reactome:R-HSA-2173796|reactome:R-HSA-3000178|reactome:R-HSA-75205|refseq:NP_000593.1	ensembl:ENST00000259396(transcript)|go:"GO:0002682"(regulation of immune system process)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035580"(specific granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR001500(Alpha-1-acid glycoprotein)|interpro:IPR012674(Calycin)|mint:P02763|rcsb pdb:3KQ0|reactome:R-HSA-114608|reactome:R-HSA-6798695|ensembl:ENSG00000229314(gene)|refseq:NP_000598.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 4 A and Figure 5 A|comment:AGP preferentially interacted with the active form of PAI1|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2006/07/25	2014/10/16	rogid:uKgGVfJUEf7zIyf5CgJGIf5TJco9606	rogid:LHDJJ6oC7gUXo8CC7Xn6EUeA8Gk9606	intact-crc:F9AF96078A85096F|rigid:D8AbPYL3yoUzpX7yjgF2v5HL2ec	false	biotin tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02763	uniprotkb:P05121	intact:EBI-976767|uniprotkb:Q8TC16|uniprotkb:B7ZKQ5|uniprotkb:Q5T539|ensembl:ENSP00000259396|uniprotkb:Q5U067	intact:EBI-953978|ensembl:ENSP00000223095|uniprotkb:B7Z4S0|uniprotkb:F8WD53	psi-mi:a1ag1_human(display_long)|uniprotkb:Orosomucoid-1(gene name synonym)|uniprotkb:ORM1(gene name)|psi-mi:ORM1(display_short)|uniprotkb:AGP1(gene name synonym)	psi-mi:pai1_human(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:SERPINE1(gene name)|psi-mi:SERPINE1(display_short)|uniprotkb:PAI1(gene name synonym)|uniprotkb:PLANH1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Boncela et al. (2006)	imex:IM-14405|pubmed:16272158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-976803|imex:IM-14405-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000259396(transcript)|go:"GO:0002682"(regulation of immune system process)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035580"(specific granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR001500(Alpha-1-acid glycoprotein)|interpro:IPR012674(Calycin)|mint:P02763|rcsb pdb:3KQ0|reactome:R-HSA-114608|reactome:R-HSA-6798695|ensembl:ENSG00000229314(gene)|refseq:NP_000598.2	ensembl:ENSG00000106366(gene)|ensembl:ENST00000223095(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1A7C|rcsb pdb:1B3K|interpro:IPR023795|rcsb pdb:1C5G|rcsb pdb:1DB2|rcsb pdb:1DVM|rcsb pdb:1DVN|rcsb pdb:1LJ5|rcsb pdb:1OC0|rcsb pdb:3CVM|rcsb pdb:3EOX|rcsb pdb:3PB1|rcsb pdb:3Q02|rcsb pdb:3Q03|rcsb pdb:3R4L|rcsb pdb:3UT3|rcsb pdb:4AQH|rcsb pdb:4G8O|rcsb pdb:4G8R|rcsb pdb:4IC0|rcsb pdb:5BRR|rcsb pdb:5ZLZ|rcsb pdb:6GWN|rcsb pdb:6GWP|rcsb pdb:6GWQ|rcsb pdb:6I8S|rcsb pdb:6ZRV|rcsb pdb:7AQF|rcsb pdb:7AQG|rcsb pdb:9PAI|reactome:R-HSA-114608|reactome:R-HSA-1368108|reactome:R-HSA-2173796|reactome:R-HSA-3000178|reactome:R-HSA-75205|refseq:NP_000593.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 4 E|comment:AGP preferentially interacted with the active form of PAI1|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/25	2014/10/16	rogid:LHDJJ6oC7gUXo8CC7Xn6EUeA8Gk9606	rogid:uKgGVfJUEf7zIyf5CgJGIf5TJco9606	intact-crc:97B508047A4199DC|rigid:D8AbPYL3yoUzpX7yjgF2v5HL2ec	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02763	uniprotkb:P05121	intact:EBI-976767|uniprotkb:Q8TC16|uniprotkb:B7ZKQ5|uniprotkb:Q5T539|ensembl:ENSP00000259396|uniprotkb:Q5U067	intact:EBI-953978|ensembl:ENSP00000223095|uniprotkb:B7Z4S0|uniprotkb:F8WD53	psi-mi:a1ag1_human(display_long)|uniprotkb:Orosomucoid-1(gene name synonym)|uniprotkb:ORM1(gene name)|psi-mi:ORM1(display_short)|uniprotkb:AGP1(gene name synonym)	psi-mi:pai1_human(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:SERPINE1(gene name)|psi-mi:SERPINE1(display_short)|uniprotkb:PAI1(gene name synonym)|uniprotkb:PLANH1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Boncela et al. (2006)	imex:IM-14405|pubmed:16272158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1009201|imex:IM-14405-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000259396(transcript)|go:"GO:0002682"(regulation of immune system process)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035580"(specific granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR001500(Alpha-1-acid glycoprotein)|interpro:IPR012674(Calycin)|mint:P02763|rcsb pdb:3KQ0|reactome:R-HSA-114608|reactome:R-HSA-6798695|ensembl:ENSG00000229314(gene)|refseq:NP_000598.2	ensembl:ENSG00000106366(gene)|ensembl:ENST00000223095(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1A7C|rcsb pdb:1B3K|interpro:IPR023795|rcsb pdb:1C5G|rcsb pdb:1DB2|rcsb pdb:1DVM|rcsb pdb:1DVN|rcsb pdb:1LJ5|rcsb pdb:1OC0|rcsb pdb:3CVM|rcsb pdb:3EOX|rcsb pdb:3PB1|rcsb pdb:3Q02|rcsb pdb:3Q03|rcsb pdb:3R4L|rcsb pdb:3UT3|rcsb pdb:4AQH|rcsb pdb:4G8O|rcsb pdb:4G8R|rcsb pdb:4IC0|rcsb pdb:5BRR|rcsb pdb:5ZLZ|rcsb pdb:6GWN|rcsb pdb:6GWP|rcsb pdb:6GWQ|rcsb pdb:6I8S|rcsb pdb:6ZRV|rcsb pdb:7AQF|rcsb pdb:7AQG|rcsb pdb:9PAI|reactome:R-HSA-114608|reactome:R-HSA-1368108|reactome:R-HSA-2173796|reactome:R-HSA-3000178|reactome:R-HSA-75205|refseq:NP_000593.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 3|comment:The authors state that a mutant form of P05121 was used in this study.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2006/07/25	2014/10/16	rogid:LHDJJ6oC7gUXo8CC7Xn6EUeA8Gk9606	rogid:uKgGVfJUEf7zIyf5CgJGIf5TJco9606	intact-crc:B73207169334B9CC|rigid:D8AbPYL3yoUzpX7yjgF2v5HL2ec	false	-	mutation:177-177,173-173,342-342,377-377	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P05121	uniprotkb:P02763	intact:EBI-953978|ensembl:ENSP00000223095|uniprotkb:B7Z4S0|uniprotkb:F8WD53	intact:EBI-976767|uniprotkb:Q8TC16|uniprotkb:B7ZKQ5|uniprotkb:Q5T539|ensembl:ENSP00000259396|uniprotkb:Q5U067	psi-mi:pai1_human(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:SERPINE1(gene name)|psi-mi:SERPINE1(display_short)|uniprotkb:PAI1(gene name synonym)|uniprotkb:PLANH1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:a1ag1_human(display_long)|uniprotkb:Orosomucoid-1(gene name synonym)|uniprotkb:ORM1(gene name)|psi-mi:ORM1(display_short)|uniprotkb:AGP1(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Boncela et al. (2006)	imex:IM-14405|pubmed:16272158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1009212|imex:IM-14405-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106366(gene)|ensembl:ENST00000223095(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1A7C|rcsb pdb:1B3K|interpro:IPR023795|rcsb pdb:1C5G|rcsb pdb:1DB2|rcsb pdb:1DVM|rcsb pdb:1DVN|rcsb pdb:1LJ5|rcsb pdb:1OC0|rcsb pdb:3CVM|rcsb pdb:3EOX|rcsb pdb:3PB1|rcsb pdb:3Q02|rcsb pdb:3Q03|rcsb pdb:3R4L|rcsb pdb:3UT3|rcsb pdb:4AQH|rcsb pdb:4G8O|rcsb pdb:4G8R|rcsb pdb:4IC0|rcsb pdb:5BRR|rcsb pdb:5ZLZ|rcsb pdb:6GWN|rcsb pdb:6GWP|rcsb pdb:6GWQ|rcsb pdb:6I8S|rcsb pdb:6ZRV|rcsb pdb:7AQF|rcsb pdb:7AQG|rcsb pdb:9PAI|reactome:R-HSA-114608|reactome:R-HSA-1368108|reactome:R-HSA-2173796|reactome:R-HSA-3000178|reactome:R-HSA-75205|refseq:NP_000593.1	ensembl:ENST00000259396(transcript)|go:"GO:0002682"(regulation of immune system process)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035580"(specific granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR001500(Alpha-1-acid glycoprotein)|interpro:IPR012674(Calycin)|mint:P02763|rcsb pdb:3KQ0|reactome:R-HSA-114608|reactome:R-HSA-6798695|ensembl:ENSG00000229314(gene)|refseq:NP_000598.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 3|comment:The authors state that a mutant form of P05121 was used in this study.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells)	-	2006/07/25	2014/10/16	rogid:uKgGVfJUEf7zIyf5CgJGIf5TJco9606	rogid:LHDJJ6oC7gUXo8CC7Xn6EUeA8Gk9606	intact-crc:8DEBBECD65DAD0B7|rigid:D8AbPYL3yoUzpX7yjgF2v5HL2ec	false	mutation:177-177,173-173,342-342,377-377	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)