#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UUM2 uniprotkb:O59836 intact:EBI-465942|uniprotkb:Q9Y7X0|ensemblfungi:"SPBC216.06c.1:pep" intact:EBI-908382|ensemblfungi:"SPCC550.13.1:pep" psi-mi:swi1_schpo(display_long)|uniprotkb:swi1(gene name)|psi-mi:swi1(display_short)|uniprotkb:SPBC216.06c(orf name)|uniprotkb:Replication fork protection complex subunit swi1(gene name synonym) psi-mi:him1_schpo(display_long)|uniprotkb:SPCC550.13(orf name)|uniprotkb:him1(gene name)|psi-mi:him1(display_short)|uniprotkb:dfp1(gene name synonym)|uniprotkb:rad35(gene name synonym)|uniprotkb:DNA repair protein rad35(gene name synonym) psi-mi:"MI:0018"(two hybrid) Matsumoto et al. (2005) pubmed:16263721|imex:IM-19864 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-908401|imex:IM-19864-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPBC216.06c.1(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0007049"(cell cycle)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0031297"(replication fork processing)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048478"(replication fork protection)|go:"GO:0061806"(regulation of DNA recombination at centromere)|ensemblfungi:SPBC216.06c(gene)|refseq:NP_595358.1|interpro:IPR006906(Timeless protein) refseq:NP_588105.1|interpro:IPR001357(BRCT)|interpro:IPR013939(Regulatory subunit Dfp1/Him1, central region)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR038545|interpro:IPR036420|reactome:R-SPO-68962|reactome:R-SPO-176187|ensemblfungi:SPCC550.13(gene)|ensemblfungi:SPCC550.13.1(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0048478"(replication fork protection)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1903466"(regulation of mitotic DNA replication initiation)|go:"GO:1903468"(positive regulation of DNA replication initiation) - - - dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/03/22 2014/10/16 rogid:W8gC66Y4OgmZYJ65Lmr4ucHKoxU284812 rogid:jqgB/+ji7/8agWCnJgorOov7kmA284812 intact-crc:F28046308A3899C0|rigid:SG0vCjA1GlRLv6cpk7QvPIu7uzw false - sufficient binding region:88-545 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UUM2 uniprotkb:P50582 intact:EBI-465942|uniprotkb:Q9Y7X0|ensemblfungi:"SPBC216.06c.1:pep" intact:EBI-908476|uniprotkb:O94678|ensemblfungi:"SPBC776.12c.1:pep" psi-mi:swi1_schpo(display_long)|uniprotkb:swi1(gene name)|psi-mi:swi1(display_short)|uniprotkb:SPBC216.06c(orf name)|uniprotkb:Replication fork protection complex subunit swi1(gene name synonym) psi-mi:hsk1_schpo(display_long)|uniprotkb:hsk1(gene name)|psi-mi:hsk1(display_short)|uniprotkb:SPBC776.12c(orf name)|uniprotkb:Minichromosome maintenance protein kinase(gene name synonym)|uniprotkb:Cdc7-related kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsumoto et al. (2005) pubmed:16263721|imex:IM-19864 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-908440|imex:IM-19864-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPBC216.06c.1(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0007049"(cell cycle)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0031297"(replication fork processing)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048478"(replication fork protection)|go:"GO:0061806"(regulation of DNA recombination at centromere)|ensemblfungi:SPBC216.06c(gene)|refseq:NP_595358.1|interpro:IPR006906(Timeless protein) refseq:NP_596328.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-SPO-68962|reactome:R-SPO-176187|ensemblfungi:SPBC776.12c(gene)|ensemblfungi:SPBC776.12c.1(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010620"(negative regulation of transcription by transcription factor catabolism)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902975"(mitotic DNA replication initiation) - - - expression level:O59836; Q9UUM2 endogenous|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2006/03/22 2014/10/16 rogid:W8gC66Y4OgmZYJ65Lmr4ucHKoxU284812 rogid:vu2hPDUtV3VzgfiEdhiYtw5WUpU284812 intact-crc:86ED3B6D08AE7632|rigid:JtMI5suBMXmecQAqsw1cqKdIfb4 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UUM2 uniprotkb:O59836 intact:EBI-465942|uniprotkb:Q9Y7X0|ensemblfungi:"SPBC216.06c.1:pep" intact:EBI-908382|ensemblfungi:"SPCC550.13.1:pep" psi-mi:swi1_schpo(display_long)|uniprotkb:swi1(gene name)|psi-mi:swi1(display_short)|uniprotkb:SPBC216.06c(orf name)|uniprotkb:Replication fork protection complex subunit swi1(gene name synonym) psi-mi:him1_schpo(display_long)|uniprotkb:SPCC550.13(orf name)|uniprotkb:him1(gene name)|psi-mi:him1(display_short)|uniprotkb:dfp1(gene name synonym)|uniprotkb:rad35(gene name synonym)|uniprotkb:DNA repair protein rad35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsumoto et al. (2005) pubmed:16263721|imex:IM-19864 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-908440|imex:IM-19864-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPBC216.06c.1(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0007049"(cell cycle)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0031297"(replication fork processing)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048478"(replication fork protection)|go:"GO:0061806"(regulation of DNA recombination at centromere)|ensemblfungi:SPBC216.06c(gene)|refseq:NP_595358.1|interpro:IPR006906(Timeless protein) refseq:NP_588105.1|interpro:IPR001357(BRCT)|interpro:IPR013939(Regulatory subunit Dfp1/Him1, central region)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR038545|interpro:IPR036420|reactome:R-SPO-68962|reactome:R-SPO-176187|ensemblfungi:SPCC550.13(gene)|ensemblfungi:SPCC550.13.1(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0048478"(replication fork protection)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1903466"(regulation of mitotic DNA replication initiation)|go:"GO:1903468"(positive regulation of DNA replication initiation) - - - expression level:O59836; Q9UUM2 endogenous|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2006/03/22 2014/10/16 rogid:W8gC66Y4OgmZYJ65Lmr4ucHKoxU284812 rogid:jqgB/+ji7/8agWCnJgorOov7kmA284812 intact-crc:86ED3B6D08AE7632|rigid:JtMI5suBMXmecQAqsw1cqKdIfb4 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P40377 uniprotkb:Q9UUM2 intact:EBI-783248|ensemblfungi:"SPBC4.04c.1:pep" intact:EBI-465942|uniprotkb:Q9Y7X0|ensemblfungi:"SPBC216.06c.1:pep" psi-mi:mcm2_schpo(display_long)|uniprotkb:Minichromosome maintenance protein 2(gene name synonym)|uniprotkb:Cell division control protein 19(gene name synonym)|uniprotkb:mcm2(gene name)|psi-mi:mcm2(display_short)|uniprotkb:cdc19(gene name synonym)|uniprotkb:nda1(gene name synonym)|uniprotkb:SPBC4.04c(orf name) psi-mi:swi1_schpo(display_long)|uniprotkb:swi1(gene name)|psi-mi:swi1(display_short)|uniprotkb:SPBC216.06c(orf name)|uniprotkb:Replication fork protection complex subunit swi1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsumoto et al. (2005) pubmed:16263721|imex:IM-19864 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-908516|imex:IM-19864-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR018525|interpro:IPR001208(MCM)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_595477.1|interpro:IPR008045(MCM protein 2)|reactome:R-SPO-176187|interpro:IPR031327|reactome:R-SPO-68962|reactome:R-SPO-69052|interpro:IPR027417|interpro:IPR027925|interpro:IPR033762|interpro:IPR041562|reactome:R-SPO-68867|ensemblfungi:SPBC4.04c(gene)|ensemblfungi:SPBC4.04c.1(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006279"(premeiotic DNA replication)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0042555"(MCM complex)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0046872"(metal ion binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|reactome:R-SPO-68949 ensemblfungi:SPBC216.06c.1(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0007049"(cell cycle)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0031297"(replication fork processing)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048478"(replication fork protection)|go:"GO:0061806"(regulation of DNA recombination at centromere)|ensemblfungi:SPBC216.06c(gene)|refseq:NP_595358.1|interpro:IPR006906(Timeless protein) - - - expression level:Q9UUM2 endogenous|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2006/03/22 2014/10/16 rogid:b9w/1QXwh2OswMQSi6nQDuxooNg284812 rogid:W8gC66Y4OgmZYJ65Lmr4ucHKoxU284812 intact-crc:91378CC8F7145367|rigid:By65x5ykZNFOTJ50Em6Xd3s0eFk false - flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)