#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O95477 uniprotkb:O60941-1 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-784173|ensembl:ENSP00000384084 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:o60941-1(display_long)|uniprotkb:DTN-B1(isoform synonym)|uniprotkb:DTNB(gene name)|psi-mi:DTNB(display_short)|uniprotkb:Beta-dystrobrevin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-784135|imex:IM-20073-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 intact:EBI-740402(dtnb_human)|ensembl:ENSG00000138101(gene)|ensembl:ENST00000406818(transcript) - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:/yB9vgxJOii2Uk4riTNLOhf9gUk9606 intact-crc:F4AC853BC3E0480F|rigid:QVts5sFgAOoBEYl9ABcGyeim99Y false binding-associated region:?-?|flag tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O95477 uniprotkb:P46939 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-295856|intact:EBI-784141|uniprotkb:Q5SZ57|uniprotkb:Q5SYY1|uniprotkb:Q9UJ40|ensembl:ENSP00000356515 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:utrn_human(display_long)|uniprotkb:UTRN(gene name)|psi-mi:UTRN(display_short)|uniprotkb:DMDL(gene name synonym)|uniprotkb:Dystrophin-related protein 1(gene name synonym)|uniprotkb:DRP1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-784135|imex:IM-20073-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 ensembl:ENSP00000356515|refseq:XP_011534408.1|refseq:NP_009055.2|refseq:XP_005267187.1|dip:DIP-711N|ensembl:ENSG00000152818(gene)|ensembl:ENST00000367545(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030175"(filopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|mint:P46939|rcsb pdb:1BHD|rcsb pdb:1QAG|rcsb pdb:6M5G|reactome:R-HSA-9619665 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:metWqbqGtzonNZ1mgNjlFrenuI89606 intact-crc:F4AC853BC3E0480F|rigid:QVts5sFgAOoBEYl9ABcGyeim99Y false binding-associated region:?-?|flag tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O95477 uniprotkb:Q13884 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-295843|uniprotkb:O14912|uniprotkb:Q4KMG8|uniprotkb:A8K9E0|ensembl:ENSP00000378965|ensembl:ENSP00000431124 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:sntb1_human(display_long)|uniprotkb:SNTB1(gene name)|psi-mi:SNTB1(display_short)|uniprotkb:SNT2B1(gene name synonym)|uniprotkb:59 kDa dystrophin-associated protein A1 basic component 1(gene name synonym)|uniprotkb:Tax interaction protein 43(gene name synonym)|uniprotkb:Syntrophin-2(gene name synonym)|uniprotkb:BSYN2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-784135|imex:IM-20073-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:XP_011515541.1|refseq:NP_066301.1|dip:DIP-466N|ensembl:ENSG00000172164(gene)|ensembl:ENST00000395601(transcript)|ensembl:ENST00000517992(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR036034|interpro:IPR041428|mint:Q13884 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:ysg02ZmUoj12kFHjpHE68vA1lUs9606 intact-crc:F4AC853BC3E0480F|rigid:QVts5sFgAOoBEYl9ABcGyeim99Y false binding-associated region:?-?|flag tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O95477 uniprotkb:Q13424 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-717191|intact:EBI-28985258|ensembl:ENSP00000217381|uniprotkb:Q16438|uniprotkb:A8K7H9|uniprotkb:E1P5N1|uniprotkb:B4DX40 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:snta1_human(display_long)|uniprotkb:59 kDa dystrophin-associated protein A1 acidic component 1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 1(gene name synonym)|uniprotkb:Syntrophin-1(gene name synonym)|uniprotkb:SNTA1(gene name)|psi-mi:SNTA1(display_short)|uniprotkb:SNT1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-784135|imex:IM-20073-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 ensembl:ENSG00000101400(gene)|ensembl:ENST00000217381(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003117"(regulation of vasoconstriction by circulating norepinephrine)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006936"(muscle contraction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016013"(syntrophin complex)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|refseq:NP_003089.1|ensembl:ENSP00000217381|go:"GO:0042383"(sarcolemma)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR028552|interpro:IPR036034|interpro:IPR041428|dip:DIP-966N - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:ZeVEy6ZeNSJx2vwfHg0WaEu80OE9606 intact-crc:F4AC853BC3E0480F|rigid:QVts5sFgAOoBEYl9ABcGyeim99Y false binding-associated region:?-?|flag tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O95477 uniprotkb:Q13425-1 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-289693|ensembl:ENSP00000338191 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:q13425-1(display_long)|uniprotkb:SNTB2(gene name)|psi-mi:SNTB2(display_short)|uniprotkb:D16S2531E(gene name synonym)|uniprotkb:SNT2B2(gene name synonym)|uniprotkb:SNTL(gene name synonym)|uniprotkb:59 kDa dystrophin-associated protein A1 basic component 2(gene name synonym)|uniprotkb:Syntrophin-3(gene name synonym)|uniprotkb:Syntrophin-like(gene name synonym)|uniprotkb:Beta2-syntrophin58(isoform synonym) psi-mi:"MI:0004"(affinity chromatography technology) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-784135|imex:IM-20073-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 ensembl:ENSG00000168807(gene)|ensembl:ENST00000336278(transcript)|intact:EBI-80411(sntb2_human) - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:SABgmvArdLH93OpFobs/L3BleVY9606 intact-crc:F4AC853BC3E0480F|rigid:QVts5sFgAOoBEYl9ABcGyeim99Y false binding-associated region:?-?|flag tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O95477 uniprotkb:Q13884 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-295843|uniprotkb:O14912|uniprotkb:Q4KMG8|uniprotkb:A8K9E0|ensembl:ENSP00000378965|ensembl:ENSP00000431124 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:sntb1_human(display_long)|uniprotkb:SNTB1(gene name)|psi-mi:SNTB1(display_short)|uniprotkb:SNT2B1(gene name synonym)|uniprotkb:59 kDa dystrophin-associated protein A1 basic component 1(gene name synonym)|uniprotkb:Tax interaction protein 43(gene name synonym)|uniprotkb:Syntrophin-2(gene name synonym)|uniprotkb:BSYN2(gene name synonym) psi-mi:"MI:0047"(far western blotting) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-784204|imex:IM-20073-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:XP_011515541.1|refseq:NP_066301.1|dip:DIP-466N|ensembl:ENSG00000172164(gene)|ensembl:ENST00000395601(transcript)|ensembl:ENST00000517992(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR036034|interpro:IPR041428|mint:Q13884 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:ysg02ZmUoj12kFHjpHE68vA1lUs9606 intact-crc:964EC3CAE70DA074|rigid:vKF9kZDYOo//mBZKDkRU6LKAlQc false binding-associated region:?-?|his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13884 uniprotkb:O95477 intact:EBI-295843|uniprotkb:O14912|uniprotkb:Q4KMG8|uniprotkb:A8K9E0|ensembl:ENSP00000378965|ensembl:ENSP00000431124 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:sntb1_human(display_long)|uniprotkb:SNTB1(gene name)|psi-mi:SNTB1(display_short)|uniprotkb:SNT2B1(gene name synonym)|uniprotkb:59 kDa dystrophin-associated protein A1 basic component 1(gene name synonym)|uniprotkb:Tax interaction protein 43(gene name synonym)|uniprotkb:Syntrophin-2(gene name synonym)|uniprotkb:BSYN2(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-784230|imex:IM-20073-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011515541.1|refseq:NP_066301.1|dip:DIP-466N|ensembl:ENSG00000172164(gene)|ensembl:ENST00000395601(transcript)|ensembl:ENST00000517992(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR036034|interpro:IPR041428|mint:Q13884 refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q13884.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:ysg02ZmUoj12kFHjpHE68vA1lUs9606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:FDC109E145032CA3|rigid:vKF9kZDYOo//mBZKDkRU6LKAlQc false binding-associated region:113-193 binding-associated region:?-?|biotin tag:?-? - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:Q13424 uniprotkb:O95477 intact:EBI-717191|intact:EBI-28985258|ensembl:ENSP00000217381|uniprotkb:Q16438|uniprotkb:A8K7H9|uniprotkb:E1P5N1|uniprotkb:B4DX40 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:snta1_human(display_long)|uniprotkb:59 kDa dystrophin-associated protein A1 acidic component 1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 1(gene name synonym)|uniprotkb:Syntrophin-1(gene name synonym)|uniprotkb:SNTA1(gene name)|psi-mi:SNTA1(display_short)|uniprotkb:SNT1(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-784242|imex:IM-20073-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000101400(gene)|ensembl:ENST00000217381(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003117"(regulation of vasoconstriction by circulating norepinephrine)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006936"(muscle contraction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016013"(syntrophin complex)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|refseq:NP_003089.1|ensembl:ENSP00000217381|go:"GO:0042383"(sarcolemma)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR028552|interpro:IPR036034|interpro:IPR041428|dip:DIP-966N refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q13424|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:ZeVEy6ZeNSJx2vwfHg0WaEu80OE9606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:E776F4A27AB06026|rigid:jRfpYbwQSjBTznzrmlR2CQYfzw4 false binding-associated region:87-167 biotin tag:?-?|binding-associated region:?-? - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:Q92796 uniprotkb:O95477 intact:EBI-80440|ensembl:ENSP00000363480|uniprotkb:Q9ULI8|uniprotkb:Q5JUW7|uniprotkb:D3DVU5|uniprotkb:B4E0H1|uniprotkb:Q5JUW6 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:dlg3_human(display_long)|uniprotkb:DLG3(gene name)|psi-mi:DLG3(display_short)|uniprotkb:KIAA1232(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:Neuroendocrine-DLG(gene name synonym)|uniprotkb:XLMR(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-784253|imex:IM-20073-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000082458(gene)|ensembl:ENST00000374360(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|rcsb pdb:1UM7|rcsb pdb:2FE5|rcsb pdb:2I1N|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|refseq:NP_001159750.1|refseq:NP_065781.1|refseq:NP_066943.2|refseq:XP_005262305.1|refseq:XP_016884815.1 refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q92796|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:mnuw5iq2NexP1BL90IuQ1i21xo89606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:CF2B067F8D3EA84F|rigid:kd+8luP6r0l69bPvTAhH/bIuNb8 false binding-associated region:226-310,386-464 binding-associated region:?-?|biotin tag:?-? - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O95477 uniprotkb:O15085 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-311099|intact:EBI-28988539|ensembl:ENSP00000354644|uniprotkb:Q5VY40|uniprotkb:D3DVD0|uniprotkb:Q6PFW2 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:arhgb_human(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-784280|imex:IM-20073-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 ensembl:ENSG00000132694(gene)|ensembl:ENST00000361409(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_055599.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|rcsb pdb:1HTJ|rcsb pdb:1XCG|rcsb pdb:2DLS|rcsb pdb:3KZ1|rcsb pdb:3T06|rcsb pdb:5E6P|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5TYT|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_937879.1|ensembl:ENSP00000354644|ensembl:ENST00000368194|ensembl:ENSP00000357177|dip:DIP-31622N - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q5VY40|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:1xhgHWC/U14RFSWNJmZudD2/DdQ9606 intact-crc:393F70DF30CDB39A|rigid:ACRjgBnZwbLnnf5knRIIS4K9UBw false biotin tag:?-?|binding-associated region:?-? binding-associated region:47-120 - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O95477 uniprotkb:O88952 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-821316|ensembl:ENSMUSP00000028583 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:lin7c_mouse(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:Veli3(gene name synonym)|uniprotkb:Lin7c(gene name)|psi-mi:Lin7c(display_short)|uniprotkb:Mals3(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-821325|imex:IM-20073-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:NP_035829.1|ensembl:ENSMUSG00000027162(gene)|ensembl:ENSMUST00000028583(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|reactome:R-MMU-212676 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry O88952|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:F2rasaJ64Olc9qScN79LJRqsUEE10090 intact-crc:DECDC1AFF096578A|rigid:lha2evmj0Q4KTs11xr+TbDPLpNE false binding-associated region:?-?|biotin tag:?-? binding-associated region:93-172 - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:Q9Z250 uniprotkb:O95477 intact:EBI-704603|uniprotkb:Q9Z251 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:lin7a_rat(display_long)|uniprotkb:Mammalian lin-seven protein 1(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 1(gene name synonym)|uniprotkb:Lin7a(gene name)|psi-mi:Lin7a(display_short)|uniprotkb:Mals1(gene name synonym)|uniprotkb:Veli1(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-821357|imex:IM-20073-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621256|refseq:NP_445966.1|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|reactome:R-RNO-212676|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048839"(inner ear development)|go:"GO:0097016"(L27 domain binding) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q9Z250|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:idN6PywIN4UCisrRHcL+IWuH56M10116 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:F88FBE0A8D288A80|rigid:7faVzwbWqefsu7azc9YjiRefyVc false binding-associated region:108-187 biotin tag:?-?|binding-associated region:?-? - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:Q9NZN5 uniprotkb:O95477 intact:EBI-821440|uniprotkb:O15086|uniprotkb:Q6P526|ensembl:ENSP00000380942 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:arhgc_human(display_long)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)|uniprotkb:ARHGEF12(gene name)|psi-mi:ARHGEF12(display_short)|uniprotkb:KIAA0382(gene name synonym)|uniprotkb:LARG(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-821465|imex:IM-20073-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001185594.1|refseq:NP_056128.1|refseq:NP_001288013.1|refseq:XP_011541022.1|refseq:XP_016872910.1|ensembl:ENST00000356641|ensembl:ENSP00000349056|ensembl:ENSP00000380942|dip:DIP-37887N|ensembl:ENSG00000196914(gene)|ensembl:ENST00000397843(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|rcsb pdb:1TXD|rcsb pdb:1X86|rcsb pdb:2OMJ|rcsb pdb:2OS6|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148 refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q9NZN5|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:lAnj6rTvOnWPt6fcTzMm8G1klKY9606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:D20EE1B5D1107096|rigid:PnUvzSHisiMpQ3gkZHlV8N0ArCM false binding-associated region:75-145 biotin tag:?-?|binding-associated region:?-? - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O95477 uniprotkb:O75970 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-821405|intact:EBI-2684724|uniprotkb:Q4LE30|uniprotkb:B7ZMI4|uniprotkb:A6NLC2|uniprotkb:O43798|uniprotkb:Q5CZ80|uniprotkb:Q5JTX3|uniprotkb:Q5JTX6|uniprotkb:Q5JTX7|uniprotkb:Q5JUC3|uniprotkb:Q5JUC4|uniprotkb:Q5VZ62|uniprotkb:Q8N790|intact:EBI-10961605|uniprotkb:B2RTS3|ensembl:ENSP00000320006 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:mpdz_human(display_long)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)|uniprotkb:MPDZ(gene name)|psi-mi:MPDZ(display_short)|uniprotkb:MUPP1(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-821477|imex:IM-20073-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:XP_006716948.1|refseq:XP_006716949.1|refseq:XP_006716950.1|refseq:XP_006716951.1|refseq:XP_006716952.1|refseq:XP_006716954.1|refseq:NP_003820.2|refseq:NP_001248335.1|refseq:NP_001248336.1|refseq:NP_001317566.1|refseq:XP_016870742.1|ensembl:ENSG00000107186(gene)|ensembl:ENST00000319217(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O75970|rcsb pdb:2FCF|rcsb pdb:2FNE|rcsb pdb:2IWN|rcsb pdb:2IWO|rcsb pdb:2IWP|rcsb pdb:2IWQ|rcsb pdb:2O2T|rcsb pdb:2OPG|rcsb pdb:2QG1 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry O75970|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:Q5QzIDHLoL/sWqQI7r/Kb4VLSdY9606 intact-crc:9B98A7F900CD27B7|rigid:XCPITlSnQHatWlal+AK968vZ7Go false binding-associated region:?-?|biotin tag:?-? binding-associated region:1988-2070 - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O95477 uniprotkb:Q15700 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-80426|ensembl:ENSP00000381355|uniprotkb:Q59G57|uniprotkb:Q68CQ8|uniprotkb:Q6ZTA8|uniprotkb:B7WNY8|uniprotkb:F8W9V6|uniprotkb:Q5H9Q4 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:dlg2_human(display_long)|uniprotkb:DLG2(gene name)|psi-mi:DLG2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-821488|imex:IM-20073-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 ensembl:ENSG00000150672(gene)|ensembl:ENST00000398309(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR008144(Guanylate kinase)|rcsb pdb:2BYG|rcsb pdb:2HE2|reactome:R-HSA-438066|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|reactome:R-HSA-442982|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|reactome:R-HSA-5673001|reactome:R-HSA-6794361|interpro:IPR035759|reactome:R-HSA-9609736|reactome:R-HSA-9617324|interpro:IPR036028|reactome:R-HSA-9620244|refseq:NP_001355.2|refseq:NP_001136171.1|refseq:NP_001136172.1|refseq:NP_001136174.1|refseq:NP_001193698.1 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q15700|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:hBuRCYIzH2etGCJINoeHIYFGTrc9606 intact-crc:03ED50DD1CF5E48C|rigid:vq6UC4XVrP/OY+LpHNUXq07hsQk false binding-associated region:?-?|biotin tag:?-? binding-associated region:421-499 - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O95477 uniprotkb:Q9HAP6 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-821335|ensembl:ENSP00000221459 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:lin7b_human(display_long)|uniprotkb:Mammalian lin-seven protein 2(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 2(gene name synonym)|uniprotkb:LIN7B(gene name)|psi-mi:LIN7B(display_short)|uniprotkb:MALS2(gene name synonym)|uniprotkb:VELI2(gene name synonym)|uniprotkb:UNQ3116/PRO10200(orf name) psi-mi:"MI:0081"(peptide array) Okuhira et al. (2005) pubmed:16192269|imex:IM-20073 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-821538|imex:IM-20073-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:NP_071448.1|refseq:NP_001295348.1|ensembl:ENSG00000104863(gene)|ensembl:ENST00000221459(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|rcsb pdb:2DKR|reactome:R-HSA-212676|reactome:R-HSA-5666185|reactome:R-HSA-6794361|reactome:R-HSA-9609736 - - - comment:PDZ domian co-ordinates were taken from Uniprot entry Q9AHP6|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/25 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:pqMho0Wcfqjj6KyO9SAMJQ5X8ns9606 intact-crc:A872A65B5A7DE72E|rigid:fQoOzSyEPsYHu6iocmycCMUQvhc false binding-associated region:?-?|biotin tag:?-? binding-associated region:93-172 - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0411"(enzyme linked immunosorbent assay)