#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04228	uniprotkb:Q08109	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0096"(pull down)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008434	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	-	crc64:DA4DDD3D624C17B8	-	figure legend:Fig. 3A, 3C	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:41435BDD8E471CA4|rigid:3YLbwA1XLJOZKqqB+8k2ox9ewTo	false	tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04228	uniprotkb:P40318	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:"MI:0096"(pull down)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008434	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	-	crc64:DA4DDD3D624C17B8	crc64:3EDFF7F9D90A0C8C	figure legend:Fig. 3A, 3C	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	intact-crc:41435BDD8E471CA4|rigid:3YLbwA1XLJOZKqqB+8k2ox9ewTo	false	tag:c-c	myc tag:c-c|mutation decreasing interaction:93-93	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04228	uniprotkb:P25694	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0096"(pull down)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008434	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:DA4DDD3D624C17B8	crc64:02ADDB9A227614D8	figure legend:Fig. 3A, 3C	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:41435BDD8E471CA4|rigid:3YLbwA1XLJOZKqqB+8k2ox9ewTo	false	tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40318	uniprotkb:Q04228	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	crc64:3EDFF7F9D90A0C8C	crc64:DA4DDD3D624C17B8	figure legend:Fig. 3B	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:C19A9AABB044BBE1|rigid:DMAAsbXFho08/rlGnQKpCyAkzA4	false	myc tag:c-c	glutathione s tranferase tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33755	uniprotkb:Q05787	intact:EBI-12193|uniprotkb:D6VQG6|ensemblfungi:YBR170C	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	psi-mi:npl4_yeast(display_long)|uniprotkb:NPL4(gene name)|psi-mi:NPL4(display_short)|uniprotkb:YBR170C(locus name)|uniprotkb:YBR1231(orf name)|uniprotkb:HRD4(gene name synonym)|uniprotkb:HMG-CoA reductase degradation protein 4(gene name synonym)	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008463	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YBR170C(gene)|ensemblfungi:YBR170C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR007716(NPL4, zinc-binding putative)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR029071|interpro:IPR037518|rcsb pdb:6JWH|rcsb pdb:6JWI|rcsb pdb:6JWJ|interpro:IPR007717(NPL4)|rcsb pdb:6OA9|rcsb pdb:6OAA|reactome:R-SCE-110320|refseq:NP_009729.1|sgd:S000000374|dip:DIP-1475N|mint:P33755	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346	-	crc64:6EF35D21338EE07E	-	figure legend:Fig. 3D|comment:Interaction between NPL4 and HRD1 and HRD3 requires functional UBX2.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:2+0sYJtYCsEX5lm8Tk91hNDj8II559292	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	intact-crc:ABB20939041FB1D6|rigid:sfeg9RLVhTfQICttCD4HTozvUsw	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33755	uniprotkb:P25694	intact:EBI-12193|uniprotkb:D6VQG6|ensemblfungi:YBR170C	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:npl4_yeast(display_long)|uniprotkb:NPL4(gene name)|psi-mi:NPL4(display_short)|uniprotkb:YBR170C(locus name)|uniprotkb:YBR1231(orf name)|uniprotkb:HRD4(gene name synonym)|uniprotkb:HMG-CoA reductase degradation protein 4(gene name synonym)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008463	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YBR170C(gene)|ensemblfungi:YBR170C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR007716(NPL4, zinc-binding putative)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR029071|interpro:IPR037518|rcsb pdb:6JWH|rcsb pdb:6JWI|rcsb pdb:6JWJ|interpro:IPR007717(NPL4)|rcsb pdb:6OA9|rcsb pdb:6OAA|reactome:R-SCE-110320|refseq:NP_009729.1|sgd:S000000374|dip:DIP-1475N|mint:P33755	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:6EF35D21338EE07E	crc64:02ADDB9A227614D8	figure legend:Fig. 3D|comment:Interaction between NPL4 and HRD1 and HRD3 requires functional UBX2.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:2+0sYJtYCsEX5lm8Tk91hNDj8II559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:ABB20939041FB1D6|rigid:sfeg9RLVhTfQICttCD4HTozvUsw	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33755	uniprotkb:Q08109	intact:EBI-12193|uniprotkb:D6VQG6|ensemblfungi:YBR170C	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:npl4_yeast(display_long)|uniprotkb:NPL4(gene name)|psi-mi:NPL4(display_short)|uniprotkb:YBR170C(locus name)|uniprotkb:YBR1231(orf name)|uniprotkb:HRD4(gene name synonym)|uniprotkb:HMG-CoA reductase degradation protein 4(gene name synonym)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008463	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YBR170C(gene)|ensemblfungi:YBR170C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR007716(NPL4, zinc-binding putative)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR029071|interpro:IPR037518|rcsb pdb:6JWH|rcsb pdb:6JWI|rcsb pdb:6JWJ|interpro:IPR007717(NPL4)|rcsb pdb:6OA9|rcsb pdb:6OAA|reactome:R-SCE-110320|refseq:NP_009729.1|sgd:S000000374|dip:DIP-1475N|mint:P33755	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	-	crc64:6EF35D21338EE07E	-	figure legend:Fig. 3D|comment:Interaction between NPL4 and HRD1 and HRD3 requires functional UBX2.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:2+0sYJtYCsEX5lm8Tk91hNDj8II559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:ABB20939041FB1D6|rigid:sfeg9RLVhTfQICttCD4HTozvUsw	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25694	uniprotkb:P40318	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1102284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	-	crc64:02ADDB9A227614D8	crc64:3EDFF7F9D90A0C8C	figure legend:Fig. 3E|comment:Interaction of SSM4 with CDC48 requires UBX2.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	intact-crc:D50626E9173F6A2D|rigid:EsY0KeQQAvtBj5wd1H2ftOpI7MQ	false	-	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40318	uniprotkb:P33296	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	intact:EBI-19745|uniprotkb:D3DM07|ensemblfungi:YER100W	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:ubc6_yeast(display_long)|uniprotkb:UBC6(gene name)|psi-mi:UBC6(display_short)|uniprotkb:DOA2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase UBC6(gene name synonym)|uniprotkb:Ubiquitin carrier protein UBC6(gene name synonym)|uniprotkb:YER100W(locus name)|uniprotkb:E2 ubiquitin-conjugating enzyme 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1102319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	sgd:S000000902|ensemblfungi:YER100W(gene)|ensemblfungi:YER100W_mRNA(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|reactome:R-SCE-9609523|refseq:NP_011026.3|dip:DIP-1713N|reactome:R-SCE-983168	-	crc64:3EDFF7F9D90A0C8C	crc64:6D80C35ECC9CF5AD	figure legend:Fig. 3E	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	rogid:oMsiJUWZq79Xez9RqWpgFGqWd9A559292	intact-crc:552C2F07F5A5F031|rigid:Tbb7VAuc1D0gpxY/r4F8oGt6R9Q	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02159	uniprotkb:P40318	intact:EBI-19749|uniprotkb:D6VZJ6|ensemblfungi:YMR022W	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	psi-mi:ubc7_yeast(display_long)|uniprotkb:UBC7(gene name)|psi-mi:UBC7(display_short)|uniprotkb:QRI8(gene name synonym)|uniprotkb:YMR022W(locus name)|uniprotkb:YM9711.12(orf name)|uniprotkb:Ubiquitin-protein ligase(gene name synonym)|uniprotkb:Ubiquitin carrier protein(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-18 kDa(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme 7(gene name synonym)	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1102333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013735.1|sgd:S000004624|ensemblfungi:YMR022W(gene)|ensemblfungi:YMR022W_mRNA(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2UCZ|rcsb pdb:4JQU|dip:DIP-6583N|reactome:R-SCE-8866652|reactome:R-SCE-983168	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	-	crc64:D3D297847DBB462D	crc64:3EDFF7F9D90A0C8C	figure legend:Fig. 3E	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:P+RNNw8DskAH8olbYBNGEiyJQ0o559292	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	intact-crc:A8D87AEA1D53D89B|rigid:98RcKF9dc+F22jU9HEZdxHbABLc	false	-	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40318	uniprotkb:P38428	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	intact:EBI-27580|uniprotkb:Q03507|uniprotkb:D6W090|ensemblfungi:YMR264W	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:cue1_yeast(display_long)|uniprotkb:KIS4(gene name synonym)|uniprotkb:YM8156.06(orf name)|uniprotkb:YMR264W(locus name)|uniprotkb:CUE1(gene name)|psi-mi:CUE1(display_short)|uniprotkb:Kinetochore-defect suppressor 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Neuber et al. (2005)	pubmed:16179953	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1102353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	refseq:NP_013991.1|sgd:S000004877|dip:DIP-4399N|mint:P38428|ensemblfungi:YMR264W(gene)|ensemblfungi:YMR264W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR041158|rcsb pdb:2MYX|rcsb pdb:4JQU	-	crc64:3EDFF7F9D90A0C8C	-	figure legend:Fig. 3E	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	rogid:hZQCZOvLvQ57CVpmIDu6A4sgUxE559292	intact-crc:3EDE8C50C6BC8E6D|rigid:EGter2GKBHdPrqQ6c1P7gHmLvKU	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)