#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04228	uniprotkb:P53044	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008571|imex:IM-19033-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	crc64:DA4DDD3D624C17B8	crc64:198E0CD48B863B98	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:92EE290F13700D14|rigid:wHS0hZ/JN1JifJXlCgHKz7Kymks	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04228	uniprotkb:P25694	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008571|imex:IM-19033-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:DA4DDD3D624C17B8	crc64:02ADDB9A227614D8	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:92EE290F13700D14|rigid:wHS0hZ/JN1JifJXlCgHKz7Kymks	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33755	uniprotkb:P53044	intact:EBI-12193|uniprotkb:D6VQG6|ensemblfungi:YBR170C	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:npl4_yeast(display_long)|uniprotkb:NPL4(gene name)|psi-mi:NPL4(display_short)|uniprotkb:YBR170C(locus name)|uniprotkb:YBR1231(orf name)|uniprotkb:HRD4(gene name synonym)|uniprotkb:HMG-CoA reductase degradation protein 4(gene name synonym)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008579|imex:IM-19033-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YBR170C(gene)|ensemblfungi:YBR170C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR007716(NPL4, zinc-binding putative)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR029071|interpro:IPR037518|rcsb pdb:6JWH|rcsb pdb:6JWI|rcsb pdb:6JWJ|interpro:IPR007717(NPL4)|rcsb pdb:6OA9|rcsb pdb:6OAA|reactome:R-SCE-110320|refseq:NP_009729.1|sgd:S000000374|dip:DIP-1475N|mint:P33755	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	crc64:6EF35D21338EE07E	crc64:198E0CD48B863B98	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:2+0sYJtYCsEX5lm8Tk91hNDj8II559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:951CCD55CAF605E8|rigid:IxhK1nfeCsEZGif8hd2flWgbyx4	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33755	uniprotkb:Q04228	intact:EBI-12193|uniprotkb:D6VQG6|ensemblfungi:YBR170C	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:npl4_yeast(display_long)|uniprotkb:NPL4(gene name)|psi-mi:NPL4(display_short)|uniprotkb:YBR170C(locus name)|uniprotkb:YBR1231(orf name)|uniprotkb:HRD4(gene name synonym)|uniprotkb:HMG-CoA reductase degradation protein 4(gene name synonym)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008579|imex:IM-19033-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YBR170C(gene)|ensemblfungi:YBR170C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR007716(NPL4, zinc-binding putative)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR029071|interpro:IPR037518|rcsb pdb:6JWH|rcsb pdb:6JWI|rcsb pdb:6JWJ|interpro:IPR007717(NPL4)|rcsb pdb:6OA9|rcsb pdb:6OAA|reactome:R-SCE-110320|refseq:NP_009729.1|sgd:S000000374|dip:DIP-1475N|mint:P33755	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	crc64:6EF35D21338EE07E	crc64:DA4DDD3D624C17B8	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:2+0sYJtYCsEX5lm8Tk91hNDj8II559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:951CCD55CAF605E8|rigid:IxhK1nfeCsEZGif8hd2flWgbyx4	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33755	uniprotkb:P25694	intact:EBI-12193|uniprotkb:D6VQG6|ensemblfungi:YBR170C	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:npl4_yeast(display_long)|uniprotkb:NPL4(gene name)|psi-mi:NPL4(display_short)|uniprotkb:YBR170C(locus name)|uniprotkb:YBR1231(orf name)|uniprotkb:HRD4(gene name synonym)|uniprotkb:HMG-CoA reductase degradation protein 4(gene name synonym)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008579|imex:IM-19033-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YBR170C(gene)|ensemblfungi:YBR170C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR007716(NPL4, zinc-binding putative)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR029071|interpro:IPR037518|rcsb pdb:6JWH|rcsb pdb:6JWI|rcsb pdb:6JWJ|interpro:IPR007717(NPL4)|rcsb pdb:6OA9|rcsb pdb:6OAA|reactome:R-SCE-110320|refseq:NP_009729.1|sgd:S000000374|dip:DIP-1475N|mint:P33755	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:6EF35D21338EE07E	crc64:02ADDB9A227614D8	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:2+0sYJtYCsEX5lm8Tk91hNDj8II559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:951CCD55CAF605E8|rigid:IxhK1nfeCsEZGif8hd2flWgbyx4	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00729	uniprotkb:P25694	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008614|imex:IM-19033-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:7227F3489CBDD952	crc64:02ADDB9A227614D8	figure legend:Fig. 3A, S1|comment:"The interaction of PCR1 (CPY) and CDC48 and UFD1 requires UBX2."|comment:"The gly255arg mutation of PCR1 causes protein misfolding leading to degradation of the protein by ER-associated protein degradation (ERAD)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:60B518C6978D1359|rigid:1NIBfxFTYaNfXA71ElJquxlX0+A	false	ha tag:c-c|mutation increasing interaction:255-255	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00729	uniprotkb:P53044	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008614|imex:IM-19033-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	crc64:7227F3489CBDD952	crc64:198E0CD48B863B98	figure legend:Fig. 3A, S1|comment:"The interaction of PCR1 (CPY) and CDC48 and UFD1 requires UBX2."|comment:"The gly255arg mutation of PCR1 causes protein misfolding leading to degradation of the protein by ER-associated protein degradation (ERAD)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:60B518C6978D1359|rigid:1NIBfxFTYaNfXA71ElJquxlX0+A	false	ha tag:c-c|mutation increasing interaction:255-255	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00729	uniprotkb:Q04228	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008614|imex:IM-19033-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	crc64:7227F3489CBDD952	crc64:DA4DDD3D624C17B8	figure legend:Fig. 3A, S1|comment:"The interaction of PCR1 (CPY) and CDC48 and UFD1 requires UBX2."|comment:"The gly255arg mutation of PCR1 causes protein misfolding leading to degradation of the protein by ER-associated protein degradation (ERAD)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:60B518C6978D1359|rigid:1NIBfxFTYaNfXA71ElJquxlX0+A	false	ha tag:c-c|mutation increasing interaction:255-255	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12684	uniprotkb:P25694	intact:EBI-8384|uniprotkb:E9P8X3|uniprotkb:D6VZ84|ensemblfungi:YLR450W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:hmdh2_yeast(display_long)|uniprotkb:L9324.2(orf name)|uniprotkb:YLR450W(locus name)|uniprotkb:HMG2(gene name)|psi-mi:HMG2(display_short)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008636|imex:IM-19033-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013555.1|sgd:S000004442|mint:P12684|dip:DIP-6277N|ensemblfungi:YLR450W(gene)|ensemblfungi:YLR450W_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004420"("hydroxymethylglutaryl-CoA reductase (NADPH) activity")|go:"GO:0005635"(nuclear envelope)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0034399"(nuclear periphery)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR002202(Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic)|interpro:IPR004554(Hydroxymethylglutaryl-CoA reductase, class I, catalytic)|interpro:IPR009023(Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding)|interpro:IPR009029(Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding)|interpro:IPR023074|interpro:IPR023076|interpro:IPR023282|interpro:IPR025583	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:1FD9DCD3AC01B15E	crc64:02ADDB9A227614D8	figure legend:Fig. 3B, 3C, 3D|comment:The interaction of HMG2 and CDC48 and UFD1 requires the UBX domain of UBX2. The interaction of HMG2 and CDC48 also requires UFD1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:6q1hM5csy4DSYUsSGyTr8M6b9r0559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:3D20F296DE2D6063|rigid:IyxZsViR+94X7SLblm9r9jUC17g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12684	uniprotkb:P53044	intact:EBI-8384|uniprotkb:E9P8X3|uniprotkb:D6VZ84|ensemblfungi:YLR450W	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:hmdh2_yeast(display_long)|uniprotkb:L9324.2(orf name)|uniprotkb:YLR450W(locus name)|uniprotkb:HMG2(gene name)|psi-mi:HMG2(display_short)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008636|imex:IM-19033-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013555.1|sgd:S000004442|mint:P12684|dip:DIP-6277N|ensemblfungi:YLR450W(gene)|ensemblfungi:YLR450W_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004420"("hydroxymethylglutaryl-CoA reductase (NADPH) activity")|go:"GO:0005635"(nuclear envelope)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0034399"(nuclear periphery)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR002202(Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic)|interpro:IPR004554(Hydroxymethylglutaryl-CoA reductase, class I, catalytic)|interpro:IPR009023(Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding)|interpro:IPR009029(Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding)|interpro:IPR023074|interpro:IPR023076|interpro:IPR023282|interpro:IPR025583	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	crc64:1FD9DCD3AC01B15E	crc64:198E0CD48B863B98	figure legend:Fig. 3B, 3C, 3D|comment:The interaction of HMG2 and CDC48 and UFD1 requires the UBX domain of UBX2. The interaction of HMG2 and CDC48 also requires UFD1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:6q1hM5csy4DSYUsSGyTr8M6b9r0559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:3D20F296DE2D6063|rigid:IyxZsViR+94X7SLblm9r9jUC17g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12684	uniprotkb:Q04228	intact:EBI-8384|uniprotkb:E9P8X3|uniprotkb:D6VZ84|ensemblfungi:YLR450W	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:hmdh2_yeast(display_long)|uniprotkb:L9324.2(orf name)|uniprotkb:YLR450W(locus name)|uniprotkb:HMG2(gene name)|psi-mi:HMG2(display_short)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008636|imex:IM-19033-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013555.1|sgd:S000004442|mint:P12684|dip:DIP-6277N|ensemblfungi:YLR450W(gene)|ensemblfungi:YLR450W_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004420"("hydroxymethylglutaryl-CoA reductase (NADPH) activity")|go:"GO:0005635"(nuclear envelope)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0034399"(nuclear periphery)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR002202(Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic)|interpro:IPR004554(Hydroxymethylglutaryl-CoA reductase, class I, catalytic)|interpro:IPR009023(Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding)|interpro:IPR009029(Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding)|interpro:IPR023074|interpro:IPR023076|interpro:IPR023282|interpro:IPR025583	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	crc64:1FD9DCD3AC01B15E	crc64:DA4DDD3D624C17B8	figure legend:Fig. 3B, 3C, 3D|comment:The interaction of HMG2 and CDC48 and UFD1 requires the UBX domain of UBX2. The interaction of HMG2 and CDC48 also requires UFD1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:6q1hM5csy4DSYUsSGyTr8M6b9r0559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:3D20F296DE2D6063|rigid:IyxZsViR+94X7SLblm9r9jUC17g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40318	uniprotkb:Q04228	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008654|imex:IM-19033-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	crc64:3EDFF7F9D90A0C8C	crc64:DA4DDD3D624C17B8	figure legend:Fig. 3E|comment:Interaction of SSM4 and CDC48 and UFD1 requires UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:348C78637B02E23F|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40318	uniprotkb:P53044	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008654|imex:IM-19033-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	crc64:3EDFF7F9D90A0C8C	crc64:198E0CD48B863B98	figure legend:Fig. 3E|comment:Interaction of SSM4 and CDC48 and UFD1 requires UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:348C78637B02E23F|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40318	uniprotkb:P25694	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008654|imex:IM-19033-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:3EDFF7F9D90A0C8C	crc64:02ADDB9A227614D8	figure legend:Fig. 3E|comment:Interaction of SSM4 and CDC48 and UFD1 requires UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:348C78637B02E23F|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08109	uniprotkb:Q04228	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008676|imex:IM-19033-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	-	crc64:DA4DDD3D624C17B8	figure legend:Fig. 3F, 3G|comment:Interaction of HRD1 and CDC48 and UFD1 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:87ACCD3A3401268D|rigid:uvBap1M9wKOW2cVI8P2BPN1sapg	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08109	uniprotkb:P53044	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008676|imex:IM-19033-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	-	crc64:198E0CD48B863B98	figure legend:Fig. 3F, 3G|comment:Interaction of HRD1 and CDC48 and UFD1 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:87ACCD3A3401268D|rigid:uvBap1M9wKOW2cVI8P2BPN1sapg	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08109	uniprotkb:P25694	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008676|imex:IM-19033-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	-	crc64:02ADDB9A227614D8	figure legend:Fig. 3F, 3G|comment:Interaction of HRD1 and CDC48 and UFD1 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:87ACCD3A3401268D|rigid:uvBap1M9wKOW2cVI8P2BPN1sapg	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38307	uniprotkb:P25694	intact:EBI-5761|uniprotkb:D6VQJ8|ensemblfungi:YBR201W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:der1_yeast(display_long)|uniprotkb:DER1(gene name)|psi-mi:DER1(display_short)|uniprotkb:YBR1413(orf name)|uniprotkb:YBR201W(locus name)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008696|imex:IM-19033-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009760.1|sgd:S000000405|dip:DIP-4767N|mint:P38307|ensemblfungi:YBR201W(gene)|ensemblfungi:YBR201W_mRNA(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070843"(misfolded protein transport)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|rcsb pdb:6VJZ|rcsb pdb:6VK0|reactome:R-SCE-5358346	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	-	crc64:02ADDB9A227614D8	figure legend:Fig. 3H, 3I|comment:Interaction of DER1 and CDC48 and UFD1 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:N7+WHcf3DTfyF3fU1FGDTAzuE7M559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:80BF9F2011E23894|rigid:i8mm4l7dG+cFPwMnwJTgneqAhew	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38307	uniprotkb:Q04228	intact:EBI-5761|uniprotkb:D6VQJ8|ensemblfungi:YBR201W	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:der1_yeast(display_long)|uniprotkb:DER1(gene name)|psi-mi:DER1(display_short)|uniprotkb:YBR1413(orf name)|uniprotkb:YBR201W(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008696|imex:IM-19033-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009760.1|sgd:S000000405|dip:DIP-4767N|mint:P38307|ensemblfungi:YBR201W(gene)|ensemblfungi:YBR201W_mRNA(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070843"(misfolded protein transport)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|rcsb pdb:6VJZ|rcsb pdb:6VK0|reactome:R-SCE-5358346	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	-	crc64:DA4DDD3D624C17B8	figure legend:Fig. 3H, 3I|comment:Interaction of DER1 and CDC48 and UFD1 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:N7+WHcf3DTfyF3fU1FGDTAzuE7M559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:80BF9F2011E23894|rigid:i8mm4l7dG+cFPwMnwJTgneqAhew	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38307	uniprotkb:P53044	intact:EBI-5761|uniprotkb:D6VQJ8|ensemblfungi:YBR201W	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:der1_yeast(display_long)|uniprotkb:DER1(gene name)|psi-mi:DER1(display_short)|uniprotkb:YBR1413(orf name)|uniprotkb:YBR201W(locus name)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008696|imex:IM-19033-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009760.1|sgd:S000000405|dip:DIP-4767N|mint:P38307|ensemblfungi:YBR201W(gene)|ensemblfungi:YBR201W_mRNA(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070843"(misfolded protein transport)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|rcsb pdb:6VJZ|rcsb pdb:6VK0|reactome:R-SCE-5358346	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	-	crc64:198E0CD48B863B98	figure legend:Fig. 3H, 3I|comment:Interaction of DER1 and CDC48 and UFD1 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:N7+WHcf3DTfyF3fU1FGDTAzuE7M559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:80BF9F2011E23894|rigid:i8mm4l7dG+cFPwMnwJTgneqAhew	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12743	uniprotkb:P25694	intact:EBI-33192|uniprotkb:Q7LIJ5|uniprotkb:D6VT43|ensemblfungi:YDR411C	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:dfm1_yeast(display_long)|uniprotkb:DFM1(gene name)|psi-mi:DFM1(display_short)|uniprotkb:D9461.2(orf name)|uniprotkb:YDR411C(locus name)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008706|imex:IM-19033-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010699.1|sgd:S000002819|interpro:IPR007599(Der1-like)|mint:Q12743|interpro:IPR035952|ensemblfungi:YDR411C(gene)|ensemblfungi:YDR411C_mRNA(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904152"(regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|reactome:R-SCE-532668	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	-	crc64:02ADDB9A227614D8	figure legend:Fig. S2|comment:Interaction of DFM1 and CDC48 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:clZC6D/FVg3OltlNAZJ9PK7eT8s559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:7041A0E3DAE81B97|rigid:OrXueGu5QpVG3wmoRK45FuKNeco	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12743	uniprotkb:Q04228	intact:EBI-33192|uniprotkb:Q7LIJ5|uniprotkb:D6VT43|ensemblfungi:YDR411C	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:dfm1_yeast(display_long)|uniprotkb:DFM1(gene name)|psi-mi:DFM1(display_short)|uniprotkb:D9461.2(orf name)|uniprotkb:YDR411C(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008706|imex:IM-19033-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010699.1|sgd:S000002819|interpro:IPR007599(Der1-like)|mint:Q12743|interpro:IPR035952|ensemblfungi:YDR411C(gene)|ensemblfungi:YDR411C_mRNA(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904152"(regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|reactome:R-SCE-532668	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	-	crc64:DA4DDD3D624C17B8	figure legend:Fig. S2|comment:Interaction of DFM1 and CDC48 requires the UBX domain of UBX2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:clZC6D/FVg3OltlNAZJ9PK7eT8s559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:7041A0E3DAE81B97|rigid:OrXueGu5QpVG3wmoRK45FuKNeco	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P53044	uniprotkb:Q04228	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008594|imex:IM-19033-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	crc64:198E0CD48B863B98	crc64:DA4DDD3D624C17B8	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:38B252D769AE00EB|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P53044	uniprotkb:P25694	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008594|imex:IM-19033-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	-	crc64:198E0CD48B863B98	crc64:02ADDB9A227614D8	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:38B252D769AE00EB|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P53044	uniprotkb:P40318	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008594|imex:IM-19033-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	-	crc64:198E0CD48B863B98	crc64:3EDFF7F9D90A0C8C	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	intact-crc:38B252D769AE00EB|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	-	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25694	uniprotkb:P40318	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	intact:EBI-18208|uniprotkb:D6VVQ1|ensemblfungi:YIL030C	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:doa10_yeast(display_long)|uniprotkb:SSM4(gene name)|psi-mi:SSM4(display_short)|uniprotkb:DOA10(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DOA10(gene name synonym)|uniprotkb:YI3299.01C(orf name)|uniprotkb:YI9905.18C(orf name)|uniprotkb:YIL030C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008603|imex:IM-19033-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	sgd:S000001292|ensemblfungi:YIL030C(gene)|ensemblfungi:YIL030C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2M6M|refseq:NP_012234.3|dip:DIP-7286N|mint:P40318	-	crc64:02ADDB9A227614D8	crc64:3EDFF7F9D90A0C8C	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	rogid:/rWhsEcXbPYVDvgXwErWb4rlhlE559292	intact-crc:3255492184FE83B9|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	-	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25694	uniprotkb:P53044	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008603|imex:IM-19033-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044	-	crc64:02ADDB9A227614D8	crc64:198E0CD48B863B98	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292	intact-crc:3255492184FE83B9|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25694	uniprotkb:Q04228	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schuberth et al. (2005)	pubmed:16179952|imex:IM-19033	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1008603|imex:IM-19033-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	-	crc64:02ADDB9A227614D8	crc64:DA4DDD3D624C17B8	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/09/12	2014/10/16	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:3255492184FE83B9|rigid:/Tf0L4/+w3MAGYyOP27JslFWpXY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)