#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O93274	uniprotkb:Q6EHH9	intact:EBI-7735236|uniprotkb:Q9YI55|intact:MINT-1893946	intact:EBI-7735259|intact:MINT-1893924	psi-mi:fzd8_xenla(display_long)|uniprotkb:fzd8(gene name)|psi-mi:fzd8(display_short)|uniprotkb:fz8(gene name synonym)	psi-mi:q6ehh9_xenla(display_long)|uniprotkb:FRIED(gene name)|psi-mi:FRIED(display_short)	psi-mi:"MI:0018"(two hybrid)	Itoh et al. (2005)	pubmed:16086323|mint:MINT-5217880	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7735285|mint:MINT-1893960	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000539(Frizzled protein)|mint:O93274|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|refseq:NP_001079144.1|interpro:IPR015526(Frizzled related)|interpro:IPR017981|refseq:NP_001084206.1|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|mint:MINT-1893962(identity)	interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q6EHH9|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|interpro:IPR019748|interpro:IPR018979|interpro:IPR018980|interpro:IPR019749|interpro:IPR019747|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:MINT-1893961(identity)	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8, Wnt5A or Wnt3A induces expression of beta-catenin target genes. Displays an axis-inducing activity|comment:"Stoichiometry: 1.0"	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/05/02	2014/10/16	rogid:Iybk5jZto+XMp4senjNbEQAoRsY8355	rogid:R5xZFwj0mo2hdtjUvRmOQDDYnaE8355	intact-crc:91106FB2C8331D1C|rigid:02nqKNuLjDXmh25/o5kOyzQ0SNk	false	binding-associated region:525-581(MINT-1893974)|tag:?-?(MINT-1893967)	tag:?-?(MINT-1893977)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6EHH9	uniprotkb:O93274	intact:EBI-7735259|intact:MINT-1893924	intact:EBI-7735236|uniprotkb:Q9YI55|intact:MINT-1893946	psi-mi:q6ehh9_xenla(display_long)|uniprotkb:FRIED(gene name)|psi-mi:FRIED(display_short)	psi-mi:fzd8_xenla(display_long)|uniprotkb:fzd8(gene name)|psi-mi:fzd8(display_short)|uniprotkb:fz8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Itoh et al. (2005)	pubmed:16086323|mint:MINT-5217880	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7735337|mint:MINT-1893985	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q6EHH9|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|interpro:IPR019748|interpro:IPR018979|interpro:IPR018980|interpro:IPR019749|interpro:IPR019747|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:MINT-1893986(identity)	interpro:IPR000539(Frizzled protein)|mint:O93274|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|refseq:NP_001079144.1|interpro:IPR015526(Frizzled related)|interpro:IPR017981|refseq:NP_001084206.1|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|mint:MINT-1893994(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8, Wnt5A or Wnt3A induces expression of beta-catenin target genes. Displays an axis-inducing activity|comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:mint	taxid:8355(xenla-embryo)|taxid:8355(Xenopus laevis embryo)	-	2006/05/02	2014/10/16	rogid:R5xZFwj0mo2hdtjUvRmOQDDYnaE8355	rogid:Iybk5jZto+XMp4senjNbEQAoRsY8355	intact-crc:BE9E98B65D9BA9BA|rigid:02nqKNuLjDXmh25/o5kOyzQ0SNk	false	myc tag:?-?(MINT-1893992)|binding-associated region:1676-2229(MINT-1894009)	binding-associated region:525-581(MINT-1893995)|glutathione s tranferase tag:?-?(MINT-1894002)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)