#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06933	uniprotkb:A2AN08	intact:EBI-7730971|intact:MINT-1353599	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:ve7_bpv1(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	DeMasi et al. (2005)	pubmed:16081543|mint:MINT-5217875	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7730966|mint:MINT-73452	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000148(Papillomavirus E7 protein)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0042025"(host cell nucleus)|go:"GO:0030430"(host cell cytoplasm)|refseq:NP_056738.1|mint:MINT-1353619(identity)	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)|mint:MINT-1353628(identity)	-	function:E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3 F5|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-c-127)|taxid:10090(Mus musculus)	-	2006/01/10	2014/10/16	rogid:FJFsdJ1IcTzwuIX4oKHYohwilmU337052	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	intact-crc:9174780961323C4A|rigid:FTOjw7jfStSlLct534xLoPVxOY8	false	mutation decreasing interaction:5-9(MINT-1353620)|flag tag:?-?(MINT-1353622)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P06933	uniprotkb:A2AN08	intact:EBI-7730971|intact:MINT-1353599	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:ve7_bpv1(display_long)|uniprotkb:E7(gene name)|psi-mi:E7(display_short)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	DeMasi et al. (2005)	pubmed:16081543|mint:MINT-5217875	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7731045|mint:MINT-73451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000148(Papillomavirus E7 protein)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0042025"(host cell nucleus)|go:"GO:0030430"(host cell cytoplasm)|refseq:NP_056738.1|mint:MINT-1353638(identity)	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)|mint:MINT-1353645(identity)	-	function:E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-c-127)|taxid:10090(Mus musculus)	-	2006/01/10	2014/10/16	rogid:FJFsdJ1IcTzwuIX4oKHYohwilmU337052	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	intact-crc:FA840A046C195168|rigid:FTOjw7jfStSlLct534xLoPVxOY8	false	flag tag:?-?(MINT-1353639)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0082"(peptide massfingerprinting)