#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8TBB1	uniprotkb:Q9BT40	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-749162|uniprotkb:Q15733|uniprotkb:Q9NPJ5|uniprotkb:Q9P2R5|uniprotkb:B2R6I2|uniprotkb:B2R750|uniprotkb:D3DTH8|intact:EBI-28986464|ensembl:ENSP00000413937	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:inp5k_human(display_long)|uniprotkb:SKIP(gene name synonym)|uniprotkb:Skeletal muscle and kidney-enriched inositol phosphatase(gene name synonym)|uniprotkb:INPP5K(gene name)|psi-mi:INPP5K(display_short)|uniprotkb:PPS(gene name synonym)|uniprotkb:Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2005)	pubmed:16002321|imex:IM-18900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-914986|imex:IM-18900-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168	refseq:NP_001129114.1|refseq:NP_057616.2|refseq:NP_570122.1|refseq:XP_011522236.1|ensembl:ENST00000320345|ensembl:ENSP00000318476|ensembl:ENST00000406424|ensembl:ENSP00000385177|ensembl:ENSP00000413937|refseq:XP_005256740.1|refseq:XP_016880244.1|refseq:XP_016880245.1|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016312"(inositol bisphosphate phosphatase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034594"(phosphatidylinositol trisphosphate phosphatase activity)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046030"(inositol trisphosphate phosphatase activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097178"(ruffle assembly)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2001153"(positive regulation of renal water transport)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR041611|reactome:R-HSA-1660499|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|ensembl:ENSG00000132376(gene)|ensembl:ENST00000421807(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)	-	-	-	comment:"The coordinates of the PDZ region of the bait protein used were given in base pairs (bp) - coordinates given here are from UniProt KB entry."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/03	2014/10/16	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:8QwPQ6eR07CZ8XlPtkdG60+KFNA9606	intact-crc:190915903714D156|rigid:9SCbcT+ECN6iY/w1YzUQu48IOWs	false	sufficient binding region:274..274-359..359(IPR001478)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49757	uniprotkb:Q8TBB1	intact:EBI-915016|uniprotkb:Q6NUQ7|uniprotkb:Q86SY1|uniprotkb:Q8WW73|uniprotkb:Q9UBG1|uniprotkb:Q9UEQ4|uniprotkb:Q9UKE8|uniprotkb:Q9UKE9|uniprotkb:Q9UKF0|uniprotkb:Q9UQJ4|uniprotkb:B4E2B1|uniprotkb:B1P2N7|uniprotkb:B1P2N8|uniprotkb:B1P2N9|uniprotkb:B1P2N5|uniprotkb:B1P2N6|intact:EBI-28966915|ensembl:ENSP00000347169|ensembl:ENSP00000451300	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	psi-mi:numb_human(display_long)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:C14orf41(gene name synonym)	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:16002321|imex:IM-18900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-915006|imex:IM-18900-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000554521|ensembl:ENSP00000450817|ensembl:ENST00000554546|ensembl:ENSP00000452416|ensembl:ENSP00000451300|ensembl:ENST00000555394|ensembl:ENSP00000451625|ensembl:ENST00000555738|ensembl:ENSP00000452069|ensembl:ENST00000557597|ensembl:ENSP00000451117|ensembl:ENST00000559312|ensembl:ENSP00000452888|ensembl:ENST00000560335|ensembl:ENSP00000453209|ensembl:ENSP00000347169|ensembl:ENST00000356296|ensembl:ENSP00000348644|ensembl:ENST00000359560|ensembl:ENSP00000352563|ensembl:ENST00000535282|ensembl:ENSP00000441258|ensembl:ENST00000544991|ensembl:ENSP00000446001|refseq:NP_001307043.1|refseq:NP_001005743.1|refseq:NP_001005744.1|refseq:NP_001005745.1|refseq:NP_003735.3|dip:DIP-37981N|ensembl:ENSG00000133961(gene)|ensembl:ENST00000355058(transcript)|ensembl:ENST00000555238(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P49757|rcsb pdb:5NJJ|rcsb pdb:5NJK|reactome:R-HSA-2122948|reactome:R-HSA-437239|reactome:R-HSA-5610780|reactome:R-HSA-5632684	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168	-	-	-	comment:"The coordinates of the N terminal domain of the bait protein used were given in base pairs (bp) - coordinates given here are from UniProt KB entry."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/03	2014/10/16	rogid:X+CHBhp67o6ROnf86RCtXlCAaF49606	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	intact-crc:6A0AE69D6B0ECD53|rigid:sEFlPOjQhmmDgX1lGz70FsfUHaU	false	green fluorescent protein tag:?-?	sufficient binding region:359..359-728..728(IPR001478)|maltose binding protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TBB1	uniprotkb:Q9BT40	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-749162|uniprotkb:Q15733|uniprotkb:Q9NPJ5|uniprotkb:Q9P2R5|uniprotkb:B2R6I2|uniprotkb:B2R750|uniprotkb:D3DTH8|intact:EBI-28986464|ensembl:ENSP00000413937	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:inp5k_human(display_long)|uniprotkb:SKIP(gene name synonym)|uniprotkb:Skeletal muscle and kidney-enriched inositol phosphatase(gene name synonym)|uniprotkb:INPP5K(gene name)|psi-mi:INPP5K(display_short)|uniprotkb:PPS(gene name synonym)|uniprotkb:Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:16002321|imex:IM-18900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-915063|imex:IM-18900-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168	refseq:NP_001129114.1|refseq:NP_057616.2|refseq:NP_570122.1|refseq:XP_011522236.1|ensembl:ENST00000320345|ensembl:ENSP00000318476|ensembl:ENST00000406424|ensembl:ENSP00000385177|ensembl:ENSP00000413937|refseq:XP_005256740.1|refseq:XP_016880244.1|refseq:XP_016880245.1|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016312"(inositol bisphosphate phosphatase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034594"(phosphatidylinositol trisphosphate phosphatase activity)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046030"(inositol trisphosphate phosphatase activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097178"(ruffle assembly)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2001153"(positive regulation of renal water transport)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR041611|reactome:R-HSA-1660499|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|ensembl:ENSG00000132376(gene)|ensembl:ENST00000421807(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/03	2014/10/16	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:8QwPQ6eR07CZ8XlPtkdG60+KFNA9606	intact-crc:8B8E6B9E86D32CEF|rigid:9SCbcT+ECN6iY/w1YzUQu48IOWs	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TBB1	uniprotkb:P49757	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-915016|uniprotkb:Q6NUQ7|uniprotkb:Q86SY1|uniprotkb:Q8WW73|uniprotkb:Q9UBG1|uniprotkb:Q9UEQ4|uniprotkb:Q9UKE8|uniprotkb:Q9UKE9|uniprotkb:Q9UKF0|uniprotkb:Q9UQJ4|uniprotkb:B4E2B1|uniprotkb:B1P2N7|uniprotkb:B1P2N8|uniprotkb:B1P2N9|uniprotkb:B1P2N5|uniprotkb:B1P2N6|intact:EBI-28966915|ensembl:ENSP00000347169|ensembl:ENSP00000451300	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:numb_human(display_long)|uniprotkb:Protein S171(gene name synonym)|uniprotkb:NUMB(gene name)|psi-mi:NUMB(display_short)|uniprotkb:C14orf41(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Chen et al. (2005)	pubmed:16002321|imex:IM-18900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-915078|imex:IM-18900-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168	ensembl:ENST00000554521|ensembl:ENSP00000450817|ensembl:ENST00000554546|ensembl:ENSP00000452416|ensembl:ENSP00000451300|ensembl:ENST00000555394|ensembl:ENSP00000451625|ensembl:ENST00000555738|ensembl:ENSP00000452069|ensembl:ENST00000557597|ensembl:ENSP00000451117|ensembl:ENST00000559312|ensembl:ENSP00000452888|ensembl:ENST00000560335|ensembl:ENSP00000453209|ensembl:ENSP00000347169|ensembl:ENST00000356296|ensembl:ENSP00000348644|ensembl:ENST00000359560|ensembl:ENSP00000352563|ensembl:ENST00000535282|ensembl:ENSP00000441258|ensembl:ENST00000544991|ensembl:ENSP00000446001|refseq:NP_001307043.1|refseq:NP_001005743.1|refseq:NP_001005744.1|refseq:NP_001005745.1|refseq:NP_003735.3|dip:DIP-37981N|ensembl:ENSG00000133961(gene)|ensembl:ENST00000355058(transcript)|ensembl:ENST00000555238(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P49757|rcsb pdb:5NJJ|rcsb pdb:5NJK|reactome:R-HSA-2122948|reactome:R-HSA-437239|reactome:R-HSA-5610780|reactome:R-HSA-5632684	go:"GO:0005634"(nucleus)	-	-	comment:Interaction of LNX and NUMB changed cellular localisation of NUMB to the nuclear compartment.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/03	2014/10/16	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:X+CHBhp67o6ROnf86RCtXlCAaF49606	intact-crc:1FB46C2365C35BDB|rigid:sEFlPOjQhmmDgX1lGz70FsfUHaU	false	tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TBB1	uniprotkb:Q9BT40	intact:EBI-739832|uniprotkb:Q4W5K7|uniprotkb:Q8N4C2|uniprotkb:Q96MJ7|uniprotkb:Q9BY20|ensembl:ENSP00000263925	intact:EBI-749162|uniprotkb:Q15733|uniprotkb:Q9NPJ5|uniprotkb:Q9P2R5|uniprotkb:B2R6I2|uniprotkb:B2R750|uniprotkb:D3DTH8|intact:EBI-28986464|ensembl:ENSP00000413937	psi-mi:lnx1_human(display_long)|uniprotkb:LNX1(gene name)|psi-mi:LNX1(display_short)|uniprotkb:LNX(gene name synonym)|uniprotkb:Numb-binding protein 1(gene name synonym)|uniprotkb:Ligand of Numb-protein X 1(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 2(gene name synonym)|uniprotkb:PDZRN2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase LNX(gene name synonym)|uniprotkb:UNQ574/PRO1136(orf name)	psi-mi:inp5k_human(display_long)|uniprotkb:SKIP(gene name synonym)|uniprotkb:Skeletal muscle and kidney-enriched inositol phosphatase(gene name synonym)|uniprotkb:INPP5K(gene name)|psi-mi:INPP5K(display_short)|uniprotkb:PPS(gene name synonym)|uniprotkb:Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Chen et al. (2005)	pubmed:16002321|imex:IM-18900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-915091|imex:IM-18900-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119800.1|refseq:NP_116011.2|refseq:XP_005265842.1|refseq:XP_016864265.1|ensembl:ENSG00000072201(gene)|ensembl:ENST00000263925(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8TBB1|rcsb pdb:3B76|rcsb pdb:5H7R|rcsb pdb:5H7S|reactome:R-HSA-983168	refseq:NP_001129114.1|refseq:NP_057616.2|refseq:NP_570122.1|refseq:XP_011522236.1|ensembl:ENST00000320345|ensembl:ENSP00000318476|ensembl:ENST00000406424|ensembl:ENSP00000385177|ensembl:ENSP00000413937|refseq:XP_005256740.1|refseq:XP_016880244.1|refseq:XP_016880245.1|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016312"(inositol bisphosphate phosphatase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034594"(phosphatidylinositol trisphosphate phosphatase activity)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046030"(inositol trisphosphate phosphatase activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097178"(ruffle assembly)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2001153"(positive regulation of renal water transport)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR041611|reactome:R-HSA-1660499|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|ensembl:ENSG00000132376(gene)|ensembl:ENST00000421807(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/03	2014/10/16	rogid:tWvePnVxh9yxWl8nQd3KZhCSKKo9606	rogid:8QwPQ6eR07CZ8XlPtkdG60+KFNA9606	intact-crc:9CF031DDCD6AC477|rigid:9SCbcT+ECN6iY/w1YzUQu48IOWs	false	tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)