#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9ES64-3 uniprotkb:Q99PJ1 intact:EBI-7418919|intact:MINT-2491350 intact:EBI-6556746|uniprotkb:D6RCH0|uniprotkb:E9Q7D7|uniprotkb:E9Q7R2|uniprotkb:F6KJX4|uniprotkb:F6KKG6|uniprotkb:F6R5Z7|uniprotkb:F6RBV2|uniprotkb:F6U3Q6|uniprotkb:F6UPC9|uniprotkb:F6VPR3|uniprotkb:F6WUN7|uniprotkb:F6X715|uniprotkb:F6XPA1|uniprotkb:F6Y0A5|uniprotkb:F6YP25|uniprotkb:F6YZQ9|uniprotkb:F7ASH0|uniprotkb:F7CIN1|uniprotkb:F7D5J8|uniprotkb:F7DFU0|uniprotkb:F8VQ61|uniprotkb:H3BKS0|uniprotkb:Q0ZM15|uniprotkb:Q0ZM16|uniprotkb:Q0ZM18|uniprotkb:Q0ZM19|uniprotkb:Q0ZM20|uniprotkb:Q0ZM21|uniprotkb:Q0ZM22|uniprotkb:Q0ZM23|uniprotkb:Q0ZM24|uniprotkb:Q0ZM25|uniprotkb:Q0ZM26|uniprotkb:Q0ZM27|uniprotkb:Q0ZM28|uniprotkb:Q0ZM29|uniprotkb:Q0ZM30|uniprotkb:Q0ZM31|uniprotkb:Q0ZM32|uniprotkb:Q0ZM33|uniprotkb:Q0ZM34|uniprotkb:Q0ZM35|uniprotkb:Q0ZM37|uniprotkb:Q2VQG7|uniprotkb:Q3URZ1|uniprotkb:Q3UTS7|ensembl:ENSMUSP00000141792|uniprotkb:E9Q7R1 psi-mi:q9es64-3(display_long)|uniprotkb:a1(isoform synonym)|uniprotkb:Ush1c(gene name)|psi-mi:Ush1c(display_short)|uniprotkb:PDZ domain-containing protein(gene name synonym)|uniprotkb:Usher syndrome type-1C protein homolog(gene name synonym) psi-mi:pcd15_mouse(display_long)|uniprotkb:Pcdh15(gene name)|psi-mi:Pcdh15(display_short) psi-mi:"MI:0096"(pull down) Reiners et al. (2005) pubmed:15928608|mint:MINT-5217761|imex:IM-25047 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7641082|imex:IM-25047-1|mint:MINT-1895805 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7418968(isoform-parent)|mint:MINT-1895814(identity) ensembl:ENSMUSG00000052613(gene)|ensembl:ENSMUST00000193361(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001964"(startle response)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048839"(inner ear development)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060013"(righting reflex)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030718|interpro:IPR041149|mint:Q99PJ1|rcsb pdb:4APX|rcsb pdb:4AQ8|rcsb pdb:4AQA|rcsb pdb:4AQE|rcsb pdb:4AXW|rcsb pdb:4XXW|rcsb pdb:5KJ4|rcsb pdb:5W1D|rcsb pdb:6BWN|rcsb pdb:6C10|rcsb pdb:6C13|rcsb pdb:6C14|rcsb pdb:6CV7|rcsb pdb:6EET|rcsb pdb:6N22|rcsb pdb:5TPK|refseq:XP_006513219.1|refseq:NP_075604.2|refseq:NP_001136207.1|refseq:NP_001136208.1|refseq:NP_001136209.1|refseq:NP_001136210.1|refseq:NP_001136211.1|refseq:NP_001136212.1|refseq:NP_001136213.1|refseq:NP_001136214.1|refseq:NP_001136215.1|refseq:NP_001136218.1|refseq:NP_001136219.1|refseq:NP_001136220.1|refseq:NP_001136232.1|dip:DIP-42151N|mint:MINT-1895806(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:6DjzPH4e5qP++FVD57IMB18nfZc10090 rogid:Hg/g9gB38Qx+yyHMlcicxTlTvmA10090 intact-crc:44F9B8CAC8040587|rigid:6t7xAOUFaZESnhI2JrX/TIOjR4U false glutathione s tranferase tag:?-?(MINT-1895820)|sufficient binding region:207-292(MINT-1895859) sufficient binding region:1845-1943(MINT-1895857)|his tag:?-?(MINT-1895812) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9ES64-3 uniprotkb:Q99PF4 intact:EBI-7418919|intact:MINT-2491350 intact:EBI-7419021|uniprotkb:Q9D4N9|uniprotkb:Q99NH1|intact:MINT-1895823|uniprotkb:E9QP63|ensembl:ENSMUSP00000101101|uniprotkb:Q5QGS3|uniprotkb:Q5QGS4|uniprotkb:Q5QGS7|uniprotkb:Q5QGS8 psi-mi:q9es64-3(display_long)|uniprotkb:a1(isoform synonym)|uniprotkb:Ush1c(gene name)|psi-mi:Ush1c(display_short)|uniprotkb:PDZ domain-containing protein(gene name synonym)|uniprotkb:Usher syndrome type-1C protein homolog(gene name synonym) psi-mi:cad23_mouse(display_long)|uniprotkb:Cdh23(gene name)|psi-mi:Cdh23(display_short)|uniprotkb:Otocadherin(gene name synonym) psi-mi:"MI:0096"(pull down) Reiners et al. (2005) pubmed:15928608|mint:MINT-5217761|imex:IM-25047 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7641110|imex:IM-25047-3|mint:MINT-1895867 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7418968(isoform-parent)|mint:MINT-1895878(identity) refseq:NP_075859.2|ensembl:ENSMUSG00000012819(gene)|ensembl:ENSMUST00000105461(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0006816"(calcium ion transport)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0060091"(kinocilium)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|interpro:IPR033030|mint:Q99PF4|rcsb pdb:2WBX|rcsb pdb:2WCP|rcsb pdb:2WD0|rcsb pdb:2WHV|rcsb pdb:3MVS|rcsb pdb:4AQ8|rcsb pdb:4AQA|rcsb pdb:4AQE|rcsb pdb:4AXW|rcsb pdb:4XXW|rcsb pdb:5I8D|rcsb pdb:5TFK|rcsb pdb:5TFL|rcsb pdb:5ULU|rcsb pdb:5UN2|rcsb pdb:5UZ8|rcsb pdb:5VH2|rcsb pdb:5VT8|rcsb pdb:5WJM|rcsb pdb:6N2E|rcsb pdb:4APX|dip:DIP-42152N|refseq:XP_006513665.1|refseq:XP_017169418.1|mint:MINT-1895868(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 23 may function as hair bundle organizer perhaps by cross-linking the stereocilia|function:"Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear"|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2016/03/14 rogid:6DjzPH4e5qP++FVD57IMB18nfZc10090 rogid:7unoOfYXoR0Paq0PlxYSWt8ppoU10090 intact-crc:3B9E1AD47E83F2A1|rigid:xq+3jJ2H942mda5LenNOHaQLMwY false his tag:?-?(MINT-1895886) glutathione s tranferase tag:?-?(MINT-1895876) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9ES64 uniprotkb:Q99PJ1 intact:EBI-7418968|uniprotkb:Q9CVG7|uniprotkb:Q9ES65|intact:MINT-1895746|uniprotkb:Q91XD1 intact:EBI-6556746|uniprotkb:D6RCH0|uniprotkb:E9Q7D7|uniprotkb:E9Q7R2|uniprotkb:F6KJX4|uniprotkb:F6KKG6|uniprotkb:F6R5Z7|uniprotkb:F6RBV2|uniprotkb:F6U3Q6|uniprotkb:F6UPC9|uniprotkb:F6VPR3|uniprotkb:F6WUN7|uniprotkb:F6X715|uniprotkb:F6XPA1|uniprotkb:F6Y0A5|uniprotkb:F6YP25|uniprotkb:F6YZQ9|uniprotkb:F7ASH0|uniprotkb:F7CIN1|uniprotkb:F7D5J8|uniprotkb:F7DFU0|uniprotkb:F8VQ61|uniprotkb:H3BKS0|uniprotkb:Q0ZM15|uniprotkb:Q0ZM16|uniprotkb:Q0ZM18|uniprotkb:Q0ZM19|uniprotkb:Q0ZM20|uniprotkb:Q0ZM21|uniprotkb:Q0ZM22|uniprotkb:Q0ZM23|uniprotkb:Q0ZM24|uniprotkb:Q0ZM25|uniprotkb:Q0ZM26|uniprotkb:Q0ZM27|uniprotkb:Q0ZM28|uniprotkb:Q0ZM29|uniprotkb:Q0ZM30|uniprotkb:Q0ZM31|uniprotkb:Q0ZM32|uniprotkb:Q0ZM33|uniprotkb:Q0ZM34|uniprotkb:Q0ZM35|uniprotkb:Q0ZM37|uniprotkb:Q2VQG7|uniprotkb:Q3URZ1|uniprotkb:Q3UTS7|ensembl:ENSMUSP00000141792|uniprotkb:E9Q7R1 psi-mi:ush1c_mouse(display_long)|uniprotkb:Ush1c(gene name)|psi-mi:Ush1c(display_short)|uniprotkb:Usher syndrome type-1C protein homolog(gene name synonym)|uniprotkb:PDZ domain-containing protein(gene name synonym) psi-mi:pcd15_mouse(display_long)|uniprotkb:Pcdh15(gene name)|psi-mi:Pcdh15(display_short) psi-mi:"MI:0018"(two hybrid) Reiners et al. (2005) pubmed:15928608|mint:MINT-5217761|imex:IM-25047 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7641150|imex:IM-25047-5|mint:MINT-1895895 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR030237|mint:Q9ES64|refseq:NP_001157205.1|refseq:NP_710143.2|refseq:NP_076138.2|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030507"(spectrin binding)|go:"GO:0032029"(myosin tail binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0034622"|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1904106"(protein localization to microvillus)|go:"GO:1904970"(brush border assembly)|go:"GO:1990435"(upper tip-link density)|rcsb pdb:1V6B|interpro:IPR036034|mint:MINT-1895904(identity) ensembl:ENSMUSG00000052613(gene)|ensembl:ENSMUST00000193361(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001964"(startle response)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048839"(inner ear development)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060013"(righting reflex)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030718|interpro:IPR041149|mint:Q99PJ1|rcsb pdb:4APX|rcsb pdb:4AQ8|rcsb pdb:4AQA|rcsb pdb:4AQE|rcsb pdb:4AXW|rcsb pdb:4XXW|rcsb pdb:5KJ4|rcsb pdb:5W1D|rcsb pdb:6BWN|rcsb pdb:6C10|rcsb pdb:6C13|rcsb pdb:6C14|rcsb pdb:6CV7|rcsb pdb:6EET|rcsb pdb:6N22|rcsb pdb:5TPK|refseq:XP_006513219.1|refseq:NP_075604.2|refseq:NP_001136207.1|refseq:NP_001136208.1|refseq:NP_001136209.1|refseq:NP_001136210.1|refseq:NP_001136211.1|refseq:NP_001136212.1|refseq:NP_001136213.1|refseq:NP_001136214.1|refseq:NP_001136215.1|refseq:NP_001136218.1|refseq:NP_001136219.1|refseq:NP_001136220.1|refseq:NP_001136232.1|dip:DIP-42151N|mint:MINT-1895896(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/05/04 2014/10/16 rogid:FPcvzbPYBwFxmWloqxEfmQmaMV410090 rogid:Hg/g9gB38Qx+yyHMlcicxTlTvmA10090 intact-crc:6FB2BF3EE7655FD4|rigid:0IjHNwPaM9Wnf3UQ9NMkJSO/dsA false tag:?-?(MINT-1895910) tag:?-?(MINT-1895902)|sufficient binding region:1845-1943(MINT-1895897) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)