#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9C035-1	uniprotkb:Q2Y080	intact:EBI-924230|ensembl:ENSP00000369373|ensembl:ENSP00000507420	intact:EBI-924086	psi-mi:q9c035-1(display_long)|uniprotkb:TRIM5(gene name)|psi-mi:TRIM5(display_short)|uniprotkb:RNF88(gene name synonym)|uniprotkb:RING finger protein 88(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM5(gene name synonym)	psi-mi:q2y080_aotaz(display_long)	psi-mi:"MI:0018"(two hybrid)	Berthoux et al. (2005)	pubmed:15919943	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:30591(aotaz)|taxid:30591("Aotus azarai (Southern owl monkey)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924255	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-924214(trim5_human)|ensembl:ENSG00000132256(gene)|ensembl:ENST00000380034(transcript)|ensembl:ENST00000684655(transcript)	interpro:IPR020892|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR029000|interpro:IPR024936|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0006457"(protein folding)|go:"GO:0042802"(identical protein binding)	-	-	-	comment:The mutants TRIMStop and hu TRIMStop showed interaction.TRIMStop is a truncated version of TRIMCyp lacking the CypA domain.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/06	2014/10/16	rogid:t0YqhaJC8oQcwot7oks1LgMxdNc9606	rogid:YGUQuMR1pzgEh0wrW7ZZOv8NnTY30591	intact-crc:D7FA0DA4947ABB02|rigid:UisfEA70DXLRytCvRoMi7vYK6qA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2Y080	uniprotkb:Q0PF16	intact:EBI-924086	intact:EBI-923856|uniprotkb:Q0PF17|uniprotkb:Q2YEN1|uniprotkb:Q6GX25|uniprotkb:Q6QWF0|intact:EBI-924275|uniprotkb:Q6QWE9	psi-mi:q2y080_aotaz(display_long)	psi-mi:trim5_macmu(display_long)|uniprotkb:TRIM5(gene name)|psi-mi:TRIM5(display_short)|uniprotkb:TRIM5alpha(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Berthoux et al. (2005)	pubmed:15919943	taxid:30591(aotaz)|taxid:30591("Aotus azarai (Southern owl monkey)")	taxid:9544(macmu)|taxid:9544("Macaca mulatta (Rhesus macaque)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020892|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR029000|interpro:IPR024936|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0006457"(protein folding)|go:"GO:0042802"(identical protein binding)	rcsb pdb:5K3Q|refseq:NP_001028082.1|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003879(Butyrophylin-like)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4TKP|rcsb pdb:5EIU|rcsb pdb:5F7T|rcsb pdb:5IEA|rcsb pdb:2LM3|rcsb pdb:3UV9|rcsb pdb:4B3N|interpro:IPR027370|rcsb pdb:5W9A|interpro:IPR043136|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1902187"	-	-	-	comment:The mutants TRIMStop and hu TRIMStop showed interaction. Interaction was also observed with huTRIMStop. TRIMStop is a truncated version of TRIMCyp lacking the CypA domain.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/06	2014/10/16	rogid:YGUQuMR1pzgEh0wrW7ZZOv8NnTY30591	rogid:7bbzJ+TyTYDB967qCTuxxYmapJ89544	intact-crc:1B2B42C20DACEA35|rigid:2+l9kL/pvU2h2mfXij7twz6rknI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2Y080	uniprotkb:Q2Y080	intact:EBI-924086	intact:EBI-924086	psi-mi:q2y080_aotaz(display_long)	psi-mi:q2y080_aotaz(display_long)	psi-mi:"MI:0018"(two hybrid)	Berthoux et al. (2005)	pubmed:15919943	taxid:30591(aotaz)|taxid:30591("Aotus azarai (Southern owl monkey)")	taxid:30591(aotaz)|taxid:30591("Aotus azarai (Southern owl monkey)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924295	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020892|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR029000|interpro:IPR024936|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0006457"(protein folding)|go:"GO:0042802"(identical protein binding)	interpro:IPR020892|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR029000|interpro:IPR024936|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0006457"(protein folding)|go:"GO:0042802"(identical protein binding)	-	-	-	comment:The mutants TRIMStop and TRIMStop showed interaction.TRIMStop is a truncated version of TRIMCyp lacking the CypA domain.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/06	2014/10/16	rogid:YGUQuMR1pzgEh0wrW7ZZOv8NnTY30591	rogid:YGUQuMR1pzgEh0wrW7ZZOv8NnTY30591	intact-crc:6A8E6359F474AF2C|rigid:e/H0rijeNsORvk7+3mAKL7iPl+8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2Y080	uniprotkb:Q9C035-1	intact:EBI-924086	intact:EBI-924230|ensembl:ENSP00000369373|ensembl:ENSP00000507420	psi-mi:q2y080_aotaz(display_long)	psi-mi:q9c035-1(display_long)|uniprotkb:TRIM5(gene name)|psi-mi:TRIM5(display_short)|uniprotkb:RNF88(gene name synonym)|uniprotkb:RING finger protein 88(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Berthoux et al. (2005)	pubmed:15919943	taxid:30591(aotaz)|taxid:30591("Aotus azarai (Southern owl monkey)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924334	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020892|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR029000|interpro:IPR024936|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0006457"(protein folding)|go:"GO:0042802"(identical protein binding)	intact:EBI-924214(trim5_human)|ensembl:ENSG00000132256(gene)|ensembl:ENST00000380034(transcript)|ensembl:ENST00000684655(transcript)	-	-	-	comment:Interaction was also observed with the SPRY deficiient TRIMStop form of TRIMCyp.	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/04/06	2014/10/16	rogid:YGUQuMR1pzgEh0wrW7ZZOv8NnTY30591	rogid:t0YqhaJC8oQcwot7oks1LgMxdNc9606	intact-crc:0D75FA3C1C11FD07|rigid:UisfEA70DXLRytCvRoMi7vYK6qA	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2Y080	uniprotkb:Q9C035-1	intact:EBI-924086	intact:EBI-924230|ensembl:ENSP00000369373|ensembl:ENSP00000507420	psi-mi:q2y080_aotaz(display_long)	psi-mi:q9c035-1(display_long)|uniprotkb:TRIM5(gene name)|psi-mi:TRIM5(display_short)|uniprotkb:RNF88(gene name synonym)|uniprotkb:RING finger protein 88(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM5(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Berthoux et al. (2005)	pubmed:15919943	taxid:30591(aotaz)|taxid:30591("Aotus azarai (Southern owl monkey)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924441	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020892|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR029000|interpro:IPR024936|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0006457"(protein folding)|go:"GO:0042802"(identical protein binding)	intact:EBI-924214(trim5_human)|ensembl:ENSG00000132256(gene)|ensembl:ENST00000380034(transcript)|ensembl:ENST00000684655(transcript)	-	-	-	comment:Interaction was also observed with the SPRY deficiient TRIMStop form of TRIMCyp.	taxid:9606(human-te671)|taxid:9606(Homo sapiens  medulloblastoma)	-	2006/04/06	2014/10/16	rogid:YGUQuMR1pzgEh0wrW7ZZOv8NnTY30591	rogid:t0YqhaJC8oQcwot7oks1LgMxdNc9606	intact-crc:B3ACE76AC66FA919|rigid:UisfEA70DXLRytCvRoMi7vYK6qA	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)