#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8TBC4	uniprotkb:P61081	intact:EBI-717567|uniprotkb:O76088|uniprotkb:Q9NTU3|uniprotkb:A8K027|intact:EBI-2339745|uniprotkb:A6NLB5|ensembl:ENSP00000354340	intact:EBI-1041660|uniprotkb:O76069|uniprotkb:Q8VC50|ensembl:ENSP00000253023	psi-mi:uba3_human(display_long)|uniprotkb:Ubiquitin-like modifier-activating enzyme 3(gene name synonym)|uniprotkb:NEDD8-activating enzyme E1C(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1C(gene name synonym)|uniprotkb:UBA3(gene name)|psi-mi:UBA3(display_short)|uniprotkb:UBE1C(gene name synonym)	psi-mi:ubc12_human(display_long)|uniprotkb:UBE2M(gene name)|psi-mi:UBE2M(display_short)|uniprotkb:UBC12(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 M(gene name synonym)|uniprotkb:NEDD8 carrier protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Huang et al. (2005)	pubmed:15694336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1041674|rcsb pdb:1Y8X	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003959.3|refseq:NP_937838.1|ensembl:ENSG00000144744(gene)|ensembl:ENST00000361055(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0007113"(endomitotic cell cycle)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019781"(NEDD8 activating enzyme activity)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR014929(E2 binding)|interpro:IPR023318|interpro:IPR030468|interpro:IPR033127|interpro:IPR035985|mint:Q8TBC4|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:1YOV|rcsb pdb:2LQ7|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3FN1|rcsb pdb:3GZN|rcsb pdb:5JJM|reactome:R-HSA-5607761|reactome:R-HSA-5676590|reactome:R-HSA-8951664|reactome:R-HSA-983168	refseq:NP_003960.1|ensembl:ENSG00000130725(gene)|ensembl:ENST00000253023(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61081|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:2NVU|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4GAO|rcsb pdb:4P5O|reactome:R-HSA-2173789|reactome:R-HSA-5607761|reactome:R-HSA-5676590|dip:DIP-35679N	-	-	-	assembly:dimeric, multimeric|3d-resolution:2.4A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:6VcauGap9tDJ780/x06s6QgRr8Y9606	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo9606	intact-crc:39F108A9E8D46B81|rigid:xQhEy/eUt9OFuSXI7kmjQg0/+QM	false	sufficient binding region:368-463	sufficient binding region:27-183	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)