#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01225	uniprotkb:P23945	intact:EBI-1030645|uniprotkb:Q14D61|uniprotkb:A2TF08|uniprotkb:A5JVV3|ensembl:ENSP00000254122|ensembl:ENSP00000416606|ensembl:ENSP00000433424	intact:EBI-848239|uniprotkb:Q4QRJ3|uniprotkb:Q16225|intact:EBI-848267|uniprotkb:A8K947|uniprotkb:Q4ZFZ2|uniprotkb:Q53RW2|uniprotkb:Q05AH0|uniprotkb:G5CBS7|uniprotkb:G5E967|uniprotkb:J3KQ00|uniprotkb:A0A0A0MSC5|ensembl:ENSP00000306780	psi-mi:fshb_human(display_long)|uniprotkb:FSHB(gene name)|psi-mi:FSHB(display_short)|uniprotkb:Follicle-stimulating hormone beta subunit(gene name synonym)|uniprotkb:Follitropin beta chain(gene name synonym)	psi-mi:fshr_human(display_long)|uniprotkb:Follitropin receptor(gene name synonym)|uniprotkb:FSHR(gene name)|psi-mi:FSHR(display_short)|uniprotkb:LGR1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Fan et al. (2005)	pubmed:15662415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1041469|rcsb pdb:1XWD	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000501.1|refseq:NP_001018090.1|ensembl:ENSG00000131808(gene)|ensembl:ENST00000254122(transcript)|ensembl:ENST00000417547(transcript)|ensembl:ENST00000533718(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007292"(female gamete generation)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0016913"(follicle-stimulating hormone activity)|go:"GO:0016914"(follicle-stimulating hormone complex)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060011"(Sertoli cell proliferation)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR018245|interpro:IPR029034|rcsb pdb:1FL7|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-209822|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-35604N	refseq:NP_000136.2|refseq:NP_852111.2|dip:DIP-35605N|ensembl:ENSG00000170820(gene)|ensembl:ENST00000304421(transcript)|go:"GO:0004963"(follicle-stimulating hormone receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007292"(female gamete generation)|go:"GO:0008406"(gonad development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR002272(Follicle-stimulating hormone receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR024635|interpro:IPR026906|rcsb pdb:1XUN|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 78.100%, free 74.100%|3d-resolution:2.92A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:59ws68aVD9u6NFa6/H6pXZpkgYU9606	rogid:/X+tlZ4lvnJkOx2ze67Y3IzCUcw9606	intact-crc:CDA7DF7F023B8D23|rigid:y4KdUAVJ4kIRGBOy/WkD1S5YVMw	false	sufficient binding region:19-129	sufficient binding region:17-268	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01225	uniprotkb:P01215	intact:EBI-1030645|uniprotkb:Q14D61|uniprotkb:A2TF08|uniprotkb:A5JVV3|ensembl:ENSP00000254122|ensembl:ENSP00000416606|ensembl:ENSP00000433424	intact:EBI-718913|ensembl:ENSP00000486024	psi-mi:fshb_human(display_long)|uniprotkb:FSHB(gene name)|psi-mi:FSHB(display_short)|uniprotkb:Follicle-stimulating hormone beta subunit(gene name synonym)|uniprotkb:Follitropin beta chain(gene name synonym)	psi-mi:glha_human(display_long)|uniprotkb:Anterior pituitary glycoprotein hormones common subunit alpha(gene name synonym)|uniprotkb:Follitropin alpha chain(gene name synonym)|uniprotkb:Follicle-stimulating hormone alpha chain(gene name synonym)|uniprotkb:Lutropin alpha chain(gene name synonym)|uniprotkb:Luteinizing hormone alpha chain(gene name synonym)|uniprotkb:Thyrotropin alpha chain(gene name synonym)|uniprotkb:Thyroid-stimulating hormone alpha chain(gene name synonym)|uniprotkb:Choriogonadotropin alpha chain(gene name synonym)|uniprotkb:Chorionic gonadotrophin subunit alpha(gene name synonym)|uniprotkb:CGA(gene name)|psi-mi:CGA(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Fan et al. (2005)	pubmed:15662415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1041469|rcsb pdb:1XWD	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000501.1|refseq:NP_001018090.1|ensembl:ENSG00000131808(gene)|ensembl:ENST00000254122(transcript)|ensembl:ENST00000417547(transcript)|ensembl:ENST00000533718(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007292"(female gamete generation)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0016913"(follicle-stimulating hormone activity)|go:"GO:0016914"(follicle-stimulating hormone complex)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060011"(Sertoli cell proliferation)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR018245|interpro:IPR029034|rcsb pdb:1FL7|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-209822|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-35604N	refseq:NP_001239312.1|refseq:NP_000726.1|ensembl:ENSG00000135346(gene)|ensembl:ENST00000627148(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0016913"(follicle-stimulating hormone activity)|go:"GO:0016914"(follicle-stimulating hormone complex)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032275"(luteinizing hormone secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046884"(follicle-stimulating hormone secretion)|go:"GO:0048589"(developmental growth)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR029034|rcsb pdb:1DZ7|rcsb pdb:1E9J|rcsb pdb:1FL7|rcsb pdb:1HCN|rcsb pdb:1HD4|rcsb pdb:1HRP|rcsb pdb:1QFW|rcsb pdb:1XUL|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-193048|reactome:R-HSA-193993|reactome:R-HSA-209822|reactome:R-HSA-209968|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-8866910|reactome:R-HSA-9660821|reactome:R-HSA-975578|dip:DIP-6182N	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 78.100%, free 74.100%|3d-resolution:2.92A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:59ws68aVD9u6NFa6/H6pXZpkgYU9606	rogid:VQrwxotrJ6jIWVX7vhOF18yY6os9606	intact-crc:CDA7DF7F023B8D23|rigid:y4KdUAVJ4kIRGBOy/WkD1S5YVMw	false	sufficient binding region:19-129	sufficient binding region:25-116	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)